Distinct roles for the two Rho GDP/GTP exchange factor domains of Kalirin in regulation of neurite growth and neuronal morphology

Journal of Neuroscience

Volumn 21, Issue 21, 2001, Pages 8426-8434

  Penzes, Peter ^a   Johnson, Richard C ^a   Kambampati, Vikram ^a   Mains, Richard E ^b   Eipper, Betty A ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Cytoskeleton; Growth cone; Rac1; RhoA; Spectrin; Trio

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; ISOPROTEIN; KALIRIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SPECTRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CYTOSKELETON; GENE OVEREXPRESSION; GROWTH CONE; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY;

EID: 0035503505     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-21-08426.2001     Document Type: Article

References (30)

1. Clostridium botulinum type C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin
2. Kalirin, a cytosolic protein with spectrin-like and GDP/ GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptideprocessing enzyme
3. The Drosophila Trio plays an essential role in patterning of axons by regulating their directional extension
4. The guanine nucleotide exchange factor Trio mediates axonal development in the Drosophila embryo
5. The multidomain protein Trio binds the LAR transmembranetyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains
6. Rho GTPases and the actin cytoskeleton
7. Kalirin, a GDP/GTP exchange factor of the Dbl family, is localized to embryonic nerve, muscle, and endocrine tissue during embryonic rat development
8. Rac1 mediates collapsin-1-induced growth cone collapse
9. Isoforms of kalirin, a neuronal dbl family member, generated through use of different 5′- and 3′-ends along with an internal translational initiation site
10. Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: Inhibition of collapse by opposing mutants of rac1
11. Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
12. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF Trio reveal Trio's role in axon pathfinding
13. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
14. Rho family GTP-binding proteins in growth cone signalling
15. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
16. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
17. Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
18. An isoform of Kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction
19. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates spine morphogenesis
20. The small GTP-binding protein regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
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25. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans
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27. Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42
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29. Dbl family proteins
30. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth