Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen

ACS Chemical Biology

Volumn 8, Issue 3, 2013, Pages 549-558

  Shepard, Allan R ^a   Conrow, Raymond E ^a   Pang, Iok Hou ^a   Jacobson, Nasreen ^a   Rezwan, Mandana ^b   Rutschmann, Katrin ^b   Auerbach, Daniel ^b   Sriramaratnam, Rohitha ^c   Cornish, Virginia W ^c  

^a A Novartis Company   (United States)

^b DUALSYSTEMS BIOTECH AG   (Switzerland)

^c Department of Chemistry Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANECORTAVE; METHOTREXATE; PHOSPHODIESTERASE 6 DELTA; PHOSPHODIESTERASE VI; UNCLASSIFIED DRUG; PDE6D PROTEIN, HUMAN; PREGNANE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; DRUG MECHANISM; GLAUCOMA; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYBRID; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE; TRABECULAR MESHWORK; YEAST; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; STRUCTURE ACTIVITY RELATION; TWO HYBRID SYSTEM;

ANIMALS; CELL LINE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; METHOTREXATE; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; PREGNADIENEDIOLS; STRUCTURE-ACTIVITY RELATIONSHIP; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84875141331     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300296m     Document Type: Article

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