In vitro transport and partitioning of AL-4940, active metabolite of angiostatic agent anecortave acetate, in ocular tissues of the posterior segment

Journal of Ocular Pharmacology and Therapeutics

Volumn 26, Issue 2, 2010, Pages 137-145

  Missel, Paul ^a   Chastain, James ^a   Mitra, Ashim ^b   Kompella, Uday ^c,d   Kansara, Viral ^b   Duvvuri, Sridhar ^b   Amrite, Aniruddha ^c,e   Cheruvu, Narayan ^c,f  

^a ALCON RESEARCH LTD   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e IQVIA   (United States)

^f MEDTRONIC INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AL 4940; ANECORTAVE; ANGIOGENESIS INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHOROID; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TRANSPORT; ELECTRIC RESISTANCE; IN VITRO STUDY; MATHEMATICAL ANALYSIS; NONHUMAN; PIGMENT EPITHELIUM; SCLERA;

ANGIOGENESIS INHIBITORS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CHOROID; DIFFUSION CHAMBERS, CULTURE; ELECTRIC IMPEDANCE; HYDROCORTISONE; MEMBRANE POTENTIALS; MODELS, THEORETICAL; PREGNADIENEDIOLS; RABBITS; RETINAL PIGMENT EPITHELIUM; SCLERA;

EID: 77951682740     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2009.0132     Document Type: Article

References (46)

1. Geroski, D. H., and Edelhauser, H. F. Transscleral drug delivery for posterior segment disease. Adv. Drug Deliv. Rev. 52: 37-48, 2001. (Pubitemid 32973637)
2. Feng, X., Pilon, K., Yaacobi, Y., et al. Extraocular muscle insertions relative to the fovea and optic nerve: humans and rhesus macaque. Invest. Ophthalmol. Vis. Sci. 46: 3493-3496, 2005. (Pubitemid 44264647)
3. D'Amico, D. J., Goldberg, M. F., Hudson, H., et al.; Anecortave Acetate Clinical Study Group. Anecortave acetate as monotherapy for treatment of subfoveal neovascularization in agerelated macular degeneration: twelve-month clinical outcomes. Ophthalmology. 110: 2372-2383; discussion 2384, 2003.
4. Missel, P. J. Finite element modeling of diffusion and partitioning in biological systems: the infi nite composite medium problem. Ann. Biomed. Eng. 28: 1307-1317, 2000.
5. Missel, P., Stevens, L., Chastain, J., et al. A clear vision for drug delivery. Fluent News 15: s8-s10, 2006.
6. Missel, P. J. Hydraulic fl ow and vascular clearance infl uences on intravitreal drug delivery. Pharm. Res. 19: 1636-1647, 2002.
7. Chastain, J.E., Missel, P.J., Kiehlbauch, C.C., and Dahlin, D.C. Ocular Pharmacokinetics of Radioactivity in Rabbits Following Intravitreal Administration of 3H-Anecortave Acetate, AAPS meeting, Toronto, November 2002, AAPS PharmSci. 4(S1):332, 2002.
8. Ohtori, A., and Toj o, K. In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation. Biol. Pharm. Bull. 17: 283-290, 1994 (Pubitemid 24112351)
9. Toj o, K., Nakagawa, K., Morita, Y., et al. A pharmacokinetic model of intravitreal delivery of ganciclovir. Eur. J. Pharm. Biopharm. 47: 99-104, 1999. (Pubitemid 29185111)
10. Cheruvu, N. P., and Kompella, U. B. Bovine and porcine transscleral solute transport: infl uence of lipophilicity and the Choroid-Bruch's layer. Invest. Ophthalmol. Vis. Sci. 47: 4513-4522, 2006.
11. Kansara, V., and Mitra, A. K. Evaluation of an ex vivo model implication for carrier-mediated retinal drug delivery. Curr. Eye Res. 31: 415-426, 2006. (Pubitemid 43994959)
12. Crank, J. The Mathematics of Diffusion. 2nd ed. Oxford: Oxford University Press; 1975; p. 51.
13. Barrer, R. M. Diffusion and permeation in heterogeneous media. In: Crank, J., Park, G. S., eds. Diffusion in Polymers. New York: Academic Press; 1968; p. 176.
14. Kadam, R. S., and Kompella, U. B. Infl uence of lipophilicity on drug partitioning into sclera, choroid-rpe, retina, trabecular meshwork, and optic nerve. J. Pharmacol. Exp. Ther. 332: 1107-1120, 2009.
15. Ussing, H. H., and Zerahn, K. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol. Scand. 23: 110-127, 1951.
16. Tsuboi, S. Measurement of the volume fl ow and hydraulic conductivity across the isolated dog retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 28: 1776-1782, 1987. (Pubitemid 17165755)
17. Sinko, P. J., Lee, Y. H., Makhey, V., et al. Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin (sCT). Pharm. Res. 16: 527-533, 1999. (Pubitemid 29191297)
18. Pantzar, N., Lundin, S., Wester, L., et al. Bidirectional smallintestinal permeability in the rat to some common marker molecules in vitro. Scand. J. Gastroenterol. 29: 703-709, 1994. (Pubitemid 24261632)
19. Ohtake, K., Maeno, T., Ueda, H., et al. Poly-l-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro. Pharm. Res. 20: 153-160, 2003. (Pubitemid 36269721)
20. Polentarutti, B. I., Peterson, A. L., Sj öberg, A. K., et al. Evaluation of viability of excised rat intestinal segments in the Ussing chamber: investigation of morphology, electrical parameters, and permeability characteristics. Pharm. Res. 16: 446-454, 1999.
21. Lang, J. C., and Stiemke, M. M. Biological barriers to ocular delivery. In: Reddy, I. W., ed. Ocular Therapeutics and Drug Delivery: A Multidisciplinary Approach. Lancaster: Technomic; 1996; pp. 51-132.
22. Prince, J. H., Eglitis, I., and Ruskell, G. L. Anatomy and Histology of the Eye and Orbit in Domestic Animals. Springfi eld, IL: CC Thomas; 1960; pp. 267-274.
23. Reichenbach, A., Schnitzer, J., Friedrich, A., et al. Development of the rabbit retina. I. Size of eye and retina, and postnatal cell proliferation. Anat. Embryol. 183: 287-297, 1991.
24. Ge, J., Luo, R., and Guo, Y. Corrective change of retinal thickness measured by optical coherence tomography and histologic studies. Yan Ke Xue Bao. 15: 153-5, 178, 1999.
25. Coleman, D. J., Silverman, R. H., Chabi, A., et al. High-resolution ultrasonic imaging of the posterior segment. Ophthalmology. 111: 1344-1351, 2004. (Pubitemid 38844833)
26. Bron, A. J., Tripathi, R. C., and Tripathi, B. J. Wolff's Anatomy of the Eye and Orbit. 8th ed. New York: Oxford University Press; 1997; p. 461.
27. Steinberg, R. H., Miller, S. S., and Stern, W. H. Initial observations on the isolated retinal pigment epithelium-choroid of the cat. Invest. Ophthalmol. Vis. Sci. 17: 675-678, 1978.
28. Tsuboi, S., and Pederson, J. E. Volume fl ow across the isolated retinal pigment epithelium of cynomolgus monkey eyes. Invest. Ophthalmol. Vis. Sci. 29: 1652-1655, 1988.
29. Kimura, M., Araie, M., and Koyano, S. Movement of carboxy-fl uorescein across retinal pigment epithelium-choroid. Exp. Eye Res. 63: 51-56, 1996. (Pubitemid 26258799)
30. Frambach, D. A., Valentine, J. L., and Weiter, J. J. Initial observations of rabbit retinal pigment epithelium-choroid-sclera preparations. Invest. Ophthalmol. Vis. Sci. 29: 814-817, 1988.
31. Lennernäs, H., Nylander, S., and Ungell, A. L. Jej unal permeability: a comparison between the ussing chamber technique and the single-pass perfusion in humans. Pharm. Res. 14: 667-671, 1997. (Pubitemid 27220288)
32. Artursson, P., Ungell, A. L., and Löfroth, J. E. Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm. Res. 10: 1123-1129, 1993. (Pubitemid 23244166)
33. Legrand, C., Bour, J. M., Jacob, C., et al. Lactate dehydrogenase (LDH) activity of the cultured eukaryotic cells as marker of the number of dead cells in the medium [corrected]. J. Biotechnol. 25: 231-243, 1992.
34. Korzeniewski, C., and Callewaert, D. M. An enzyme-release assay for natural cytotoxicity. J. Immunol. Methods. 64: 313-320, 1983. (Pubitemid 14243095)
35. Goergen, J L., Marc, A., and Engasser, J. M. Determination of Cell Lysis and Death Kinetics in Continuous Hybridoma Cultures from the Measurement of Lactate Dehydrogenase Release. Cytotechnology. 11: 189-195, 1993.
36. Allen, M., Millett, P., Dawes, E., et al. Lactate dehydrogenase activity as a rapid and sensitive test for the quantifi cation of cell numbers in vitro. Clin. Mater. 16: 189-194, 1994.
37. Higashiyama, M., Inada, K., Ohtori, A., et al. Improvement of the ocular bioavailability of timolol by sorbic acid. Int. J. Pharm. 272: 91-98, 2004. (Pubitemid 38293014)
38. Andersen, M. E., Sarangapani, R., Reitz, R. H., et al. Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats. Toxicol. Sci. 60: 214-231, 2001. (Pubitemid 32273310)
39. Emond, C., Birnbaum, L. S., and DeVito, M. J. Use of a physiologically based pharmacokinetic model for rats to study the infl uence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD. Environ. Health Perspect. 114: 1394-1400, 2006. (Pubitemid 44314763)
40. Toj o, K. A pharmacokinetic model for ocular drug delivery. Chem. Pharm. Bull. 52: 1290-1294, 2004. (Pubitemid 41364444)
41. Prausnitz, M. R., and Noonan, J. S. Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye. J. Pharm. Sci. 87: 1479-1488, 1998. (Pubitemid 28559628)
42. Pitkänen, L., Ranta, V. P., Moilanen, H., et al. Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity. Invest. Ophthalmol. Vis. Sci. 46: 641-646, 2005. (Pubitemid 40270347)
43. Kim, S. H., Lutz, R. J., Wang, N. S., et al. Transport barriers in transscleral drug delivery for retinal diseases. Ophthalmic Res. 39: 244-254, 2007.
44. Cheruvu, N. P., Amrite, A. C., and Kompella, U. B. Effect of eye pigmentation on transscleral drug delivery. Invest. Ophthalmol. Vis. Sci. 49: 333-341, 2008.
45. Siegel, G. M. The golden age of retinal cell culture. Mol. Vis. 5: 4, 1999.
46. Marmorstein, A. D., Peachey, N. S., and Csaky, K. G. In vivo gene transfer as a means to study the physiology and morphogenesis of the retinal pigment epithelium in the rat. Methods. 30: 277-285, 2003.