4-Amino-2-arylamino-5-indoloyl/cinnamoythiazoles, analogs of topsentin-class of marine alkaloids, induce apoptosis in HeLa cells

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 474-483

  Juneja, Manisha ^a   Vanam, Uma ^a   Paranthaman, Sripriya ^a   Bharathan, Asha ^b   Keerthi, Venugopal S ^b   Reena, Justus K ^b   Rajaram, Rama ^c   Rajasekharan, Kallikat N ^b   Karunagaran, Devarajan ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^b UNIVERSITY OF KERALA   (India)

^c CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

Anticancer; Apoptosis; Cell cycle; Diaminothiazoles; NF B; Topsentin

Indexed keywords

4 AMINO 2 ARYLAMINO 5 INDOLOYL CINNAMOYTHIAZOLE; ALKALOID DERIVATIVE; CASPASE 3; CASPASE 8; CASPASE 9; CURCUMIN; DIAMINOCINNAMOYLTHIAZOLE DERIVATIVE; DIAMINOINDOLOYLTHIAZOLE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; THIAZOLE DERIVATIVE; TOPSENTIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; SIGNAL TRANSDUCTION;

ALKALOIDS; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL PROLIFERATION; CINNAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINTS; HELA CELLS; HUMANS; IMIDAZOLES; INDOLES; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NF-KAPPA B; PORIFERA; SEAWATER; SIGNAL TRANSDUCTION; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875081025     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.02.032     Document Type: Article

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