Induction of Thoracic Aortic Remodeling by Endothelial-Specific Deletion of MicroRNA-21 in Mice

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Zhang, Xing Yi ^a   Shen, Bao Rong ^a   Zhang, Yu Cheng ^a   Wan, Xue Jiao ^a   Yao, Qing Ping ^a   Wu, Guang Liang ^a   Wang, Ji Yao ^a   Chen, Si Guo ^a   Yan, Zhi Qiang ^a   Jiang, Zong Lai ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; CONNECTIVE TISSUE GROWTH FACTOR; ELASTIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; MICRORNA 21; SMAD7 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTERIAL WALL THICKNESS; ARTICLE; DIASTOLIC BLOOD PRESSURE; DOWN REGULATION; ENDOTHELIUM CELL; GENE DELETION; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PATHOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORACIC AORTA; UPREGULATION; VASCULAR BIOLOGY; VASCULAR DISEASE; WESTERN BLOTTING; WILD TYPE;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; ELASTIN; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; FEMALE; GENE DELETION; GENE ORDER; GENE TARGETING; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, KNOCKOUT; MICRORNAS; SMAD2 PROTEIN; SMAD5 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84875071651     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059002     Document Type: Article

References (50)

1. Ambros V, (2001) microRNAs: tiny regulators with great potential. Cell 107: 823-826.
2. Kang H, Hata A, (2012) MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin Hematol 19: 224-231.
3. Schober A, Thum T, Zernecke A (2012) MicroRNAs in vascular biology- metabolism and atherosclerosis. Thromb Haemost 8;107(4).
4. Cheng Y, Zhang C, (2010) MicroRNA-21 in cardiovascular disease. J Cardiovasc Transl Res 3: 251-255.
5. Ji R, Cheng Y, Yue J, Yang J, Liu X, et al. (2007) MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ Res 100: 1579-1588.
6. Horita HN, Simpson PA, Ostriker A, Furgeson S, Van Putten V, et al. (2011) Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 31: 2909-2919.
7. Yang S, Banerjee S, Ad F, Cui H, Xie N, et al. (2012) miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 302: L521-529.
8. Sarkar J, Gou D, Turaka P, Viktorova E, Ramchandran R, et al. (2010) MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am J Physiol Lung Cell Mol Physiol 299: L861-871.
9. Weber M, Baker MB, Moore JP, Searles CD, (2010) MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem Biophys Res Commun 393: 643-648.
10. Rippe C, Blimline M, Magerko KA, Lawson BR, LaRocca TJ, et al. (2012) MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Exp Gerontol 47: 45-51.
11. Chiu JJ, Chien S, (2011) Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev 91: 327-387.
12. Li YS, Haga JH, Chien S, (2005) Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech 38: 1949-1971.
13. Nigro P, Abe J, Berk BC, (2011) Flow shear stress and atherosclerosis: a matter of site specificity. Antioxid Redox Signal 15: 1405-1414.
14. Kobayashi M, Inoue K, Warabi E, Minami T, Kodama T, (2005) A simple method of isolating mouse aortic endothelial cells. J Atheroscler Thromb 12: 138-142.
15. Lu J, Tsourkas A, (2009) Imaging individual microRNAs in single mammalian cells in situ. Nucleic Acids Res 37: e100.
16. Fukamizu A, Sugimura K, Takimoto E, Sugiyama F, Seo MS, et al. (1993) Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J Biol Chem 268: 11617-11621.
17. Guo X, Kassab GS, (2003) Variation of mechanical properties along the length of the aorta in C57bl/6 mice. Am J Physiol Heart Circ Physiol 285: H2614-2622.
18. Benko R, Pacher P, Vaslin A, Kollai M, Szabo C, (2004) Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase. Life Sci 75: 1255-1261.
19. Jones JA, Beck C, Barbour JR, Zavadzkas JA, Mukherjee R, et al. (2009) Alterations in aortic cellular constituents during thoracic aortic aneurysm development: myofibroblast-mediated vascular remodeling. Am J Pathol 175: 1746-1756.
20. Jiang Z, Ji K, Yang X, Zhang J, (2000) Remodeling and biomechanical properties of thoracic aorta in spontaneously hypertensive rats. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 17: 66-70.
21. Whaley-Connell A, Habibi J, Cooper SA, Demarco VG, Hayden MR, et al. (2008) Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat. Am J Physiol Endocrinol Metab 295: E103-109.
22. Rodrigues P, Goncalves C, Honorio A, Barros J, Bairos V, (2008) Quantification of mouse lung elastin during prenatal development. Open Respir Med J 2: 46-51.
23. Wang CJ, Zhou ZG, Holmqvist A, Zhang H, Li Y, et al. (2009) Survivin expression quantified by Image Pro-Plus compared with visual assessment. Appl Immunohistochem Mol Morphol 17: 530-535.
24. Wei PC, Tsai CH, Chiu PS, Lai SC, (2011) Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Int J Parasitol 41: 1175-1183.
25. Uchinaka A, Kawaguchi N, Hamada Y, Miyagawa S, Saito A, et al. (2012) Transplantation of elastin-secreting myoblast sheets improves cardiac function in infarcted rat heart. Mol Cell Biochem 368: 203-214.
26. Dab H, Kacem K, Hachani R, Dhaouadi N, Hodroj W, et al. (2012) Physiological regulation of extracellular matrix collagen and elastin in the arterial wall of rats by noradrenergic tone and angiotensin II. J Renin Angiotensin Aldosterone Syst 13: 19-28.
27. Wang HQ, Huang LX, Qu MJ, Yan ZQ, Liu B, et al. (2006) Shear stress protects against endothelial regulation of vascular smooth muscle cell migration in a coculture system. Endothelium 13: 171-180.
28. Kassab GS, (2006) Biomechanics of the cardiovascular system: the aorta as an illustratory example. J R Soc Interface 3: 719-740.
29. Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, et al. (2010) miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 207: 1589-1597.
30. Cavarretta E, Latronico MV, Condorelli G, (2012) Endothelial-to-mesenchymal transition and microRNA-21: the game is on again. Arterioscler Thromb Vasc Biol 32: 165-166.
31. Reinke CA, Carthew RW, (2008) BMP signaling goes posttranscriptional in a microRNA sort of way. Dev Cell 15: 174-175.
32. Au CG, Butler TL, Sherwood MC, Egan JR, North KN, et al. (2011) Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy. Int J Exp Pathol 92: 57-65.
33. Benetos A, Zureik M, Morcet J, Thomas F, Bean K, et al. (2000) A decrease in diastolic blood pressure combined with an increase in systolic blood pressure is associated with a higher cardiovascular mortality in men. J Am Coll Cardiol 35: 673-680.
34. Huang W, Sher YP, Peck K, Fung YC, (2002) Matching gene activity with physiological functions. Proc Natl Acad Sci U S A 99: 2603-2608.
35. Shifren A, Durmowicz AG, Knutsen RH, Faury G, Mecham RP, (2008) Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure. J Appl Physiol 105: 1610-1619.
36. Briones AM, Gonzalez JM, Somoza B, Giraldo J, Daly CJ, et al. (2003) Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling. J Physiol 552: 185-195.
37. VanLandingham LG, Gannon KP, Drummond HA, (2009) Pressure-induced constriction is inhibited in a mouse model of reduced betaENaC. Am J Physiol Regul Integr Comp Physiol 297: R723-728.
38. Ritt M, Schmieder RE, (2009) Wall-to-lumen ratio of retinal arterioles as a tool to assess vascular changes. Hypertension 54: 384-387.
39. Safar ME, Boudier HS, (2005) Vascular development, pulse pressure, and the mechanisms of hypertension. Hypertension 46: 205-209.
40. Bendeck MP, Langille BL, (1991) Rapid accumulation of elastin and collagen in the aortas of sheep in the immediate perinatal period. Circ Res 69: 1165-1169.
41. Silver FH, Horvath I, Foran DJ, (2001) Viscoelasticity of the vessel wall: the role of collagen and elastic fibers. Crit Rev Biomed Eng 29: 279-301.
42. Lage SG, Polak JF, O'Leary DH, Creager MA, (1993) Relationship of arterial compliance to baroreflex function in hypertensive patients. Am J Physiol 265: H232-237.
43. Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M, Egido J, et al. (2005) Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 111: 2509-2517.
44. Massague J, Seoane J, Wotton D, (2005) Smad transcription factors. Genes Dev 19: 2783-2810.
45. Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, et al. (2005) Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res 96: 1053-1063.
46. Qi W, Chen X, Twigg S, Zhang Y, Gilbert RE, et al. (2007) The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology (Carlton) 12: 267-274.
47. Wang Q, Usinger W, Nichols B, Gray J, Xu L, et al. (2011) Cooperative interaction of CTGF and TGF-beta in animal models of fibrotic disease. Fibrogenesis Tissue Repair 4: 4.
48. Hishikawa K, Oemar BS, Tanner FC, Nakaki T, Fujii T, et al. (1999) Overexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cells. Circulation 100: 2108-2112.
49. Fan WH, Karnovsky MJ, (2002) Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. J Biol Chem 277: 9800-9805.
50. Tan TW, Lai CH, Huang CY, Yang WH, Chen HT, et al. (2009) CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. J Cell Biochem 107: 345-356.