The Importance of Prions

PLoS Pathogens

Volumn 9, Issue 1, 2013, Pages

  Telling, Glenn C ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; CHRONIC WASTING DISEASE; CREUTZFELDT JAKOB DISEASE; HUMAN; MASS SPECTROMETRY; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRION; PRION DISEASE; PUBLIC HEALTH; UNFOLDED PROTEIN RESPONSE; VIRUS MORPHOLOGY; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS TRANSMISSION;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; HOST-PATHOGEN INTERACTIONS; HUMANS; NEURODEGENERATIVE DISEASES; PRION DISEASES; PRPC PROTEINS;

EID: 84875057980     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003090     Document Type: Article

References (24)

1. Telling GC, (2011) Transgenic mouse models and prion strains. Top Curr Chem 305: 79-99.
2. Angers RC, Kang HE, Napier D, Browning S, Seward T, et al. (2010) Prion strain mutation determined by prion protein conformational compatibility and primary structure. Science 328: 1154-1158.
3. Collinge J, Clarke AR, (2007) A general model of prion strains and their pathogenicity. Science 318: 930-936.
4. Li J, Browning S, Mahal SP, Oelschlegel AM, Weissmann C, (2010) Darwinian evolution of prions in cell culture. Science 327: 869-872.
5. Beringue V, Herzog L, Jaumain E, Reine F, Sibille P, et al. (2012) Facilitated cross-species transmission of prions in extraneural tissue. Science 335: 472-475.
6. Angers RC, Browning SR, Seward TS, Sigurdson CJ, Miller MW, et al. (2006) Prions in skeletal muscles of deer with chronic wasting disease. Science 311: 1117.
7. Race B, Meade-White K, Race R, Chesebro B, (2009) Prion infectivity in fat of deer with chronic wasting disease. J Virol 83: 9608-9610.
8. Angers RC, Seward TS, Napier D, Green M, Hoover E, et al. (2009) Chronic wasting disease prions in elk antler velvet. Emerging Infectious Diseases 15: 696-703.
9. Deleault NR, Harris BT, Rees JR, Supattapone S, (2007) Formation of native prions from minimal components in vitro. Proc Natl Acad Sci U S A 104: 9741-9746.
10. Wang F, Wang X, Yuan CG, Ma J, (2010) Generating a prion with bacterially expressed recombinant prion protein. Science 327: 1132-1135.
11. Deleault NR, Piro JR, Walsh DJ, Wang F, Ma J, et al. (2012) Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids. Proc Natl Acad Sci U S A 109: 8546-8551.
12. Deleault NR, Walsh DJ, Piro JR, Wang F, Wang X, et al. (2012) Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions. Proc Natl Acad Sci U S A 109: E1938-E1946.
13. Smirnovas V, Baron GS, Offerdahl DK, Raymond GJ, Caughey B, et al. (2011) Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat Struct Mol Biol 18: 504-506.
14. Govaerts C, Wille H, Prusiner SB, Cohen FE, (2004) Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A 101: 8342-8347.
15. DeMarco ML, Daggett V, (2004) From conversion to aggregation: protofibril formation of the prion protein. Proc Natl Acad Sci U S A 101: 2293-2298.
16. Kang HE, Weng CC, Saijo E, Saylor V, Bian J, et al. (2012) Characterization of conformation-dependent prion protein epitopes. J Biol Chem 287 (44) (): 37219-37232.
17. Callahan MA, Xiong L, Caughey B, (2001) Reversibility of scrapie-associated prion protein aggregation. J Biol Chem 276: 28022-28028.
18. Soto C, (2012) Transmissible proteins: expanding the prion heresy. Cell 149: 968-977.
19. Prusiner SB, (2012) Cell biology. A unifying role for prions in neurodegenerative diseases. Science 336: 1511-1513.
20. Nazor KE, Kuhn F, Seward T, Green M, Zwald D, et al. (2005) Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice. Embo J 24: 2472-2480.
21. Morales R, Duran-Aniotz C, Castilla J, Estrada LD, Soto C, (2011) De novo induction of amyloid-beta deposition in vivo. Mol Psychiatry 17 (12) (): 1347-1353.
22. Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J, (2011) Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 470: 540-542.
23. Mallucci G, Dickinson A, Linehan J, Klohn PC, Brandner S, et al. (2003) Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science 302: 871-874.
24. Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, et al. (2012) Sustained translational repression by eIF2alpha-P mediates prion neurodegeneration. Nature 485: 507-511.