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Volumn 229, Issue 5, 2013, Pages 765-774

The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas

Author keywords

chemoradiotherapy; mitosis catastrophe; oesophageal squamous cell carcinoma; PinX1; telomere dysfunction

Indexed keywords

CISPLATIN; FLUOROURACIL; PINX1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

EID: 84875050329     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4163     Document Type: Article
Times cited : (30)

References (33)
  • 2
    • 79955805191 scopus 로고    scopus 로고
    • Esophageal cancer: Diagnosis and management
    • Lin SH, Chang JY,. Esophageal cancer: diagnosis and management. Chin J Cancer 2010; 29: 843-854.
    • (2010) Chin J Cancer , vol.29 , pp. 843-854
    • Lin, S.H.1    Chang, J.Y.2
  • 3
    • 23844440983 scopus 로고    scopus 로고
    • Clinical impact of criteria for complete response (CR) of primary site to treatment of esophageal cancer
    • Tahara M, Ohtsu A, Hironaka S, et al,. Clinical impact of criteria for complete response (CR) of primary site to treatment of esophageal cancer. Jpn J Clin Oncol 2005; 35: 316-323.
    • (2005) Jpn J Clin Oncol , vol.35 , pp. 316-323
    • Tahara, M.1    Ohtsu, A.2    Hironaka, S.3
  • 4
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, et al,. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 5
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Hahn WC, Counter CM, Lundberg AS, et al,. Creation of human tumour cells with defined genetic elements. Nature 1999; 400: 464-468.
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1    Counter, C.M.2    Lundberg, A.S.3
  • 6
    • 0031858734 scopus 로고    scopus 로고
    • Telomere length, telomerase activity and telomerase RNA expression in human esophageal cancer cells: Correlation with cell proliferation, differentiation and chemosensitivity to anticancer drugs
    • Asai A, Kiyozuka Y, Yoshida R, et al,. Telomere length, telomerase activity and telomerase RNA expression in human esophageal cancer cells: correlation with cell proliferation, differentiation and chemosensitivity to anticancer drugs. Anticancer Res 1998; 18: 1465-1472.
    • (1998) Anticancer Res , vol.18 , pp. 1465-1472
    • Asai, A.1    Kiyozuka, Y.2    Yoshida, R.3
  • 7
    • 0036140990 scopus 로고    scopus 로고
    • Telomerase activity in esophageal squamous cell carcinoma: Down-regulation by chemotherapeutic agent
    • Mitsui A, Kuwabara Y, Iwase H, et al,. Telomerase activity in esophageal squamous cell carcinoma: down-regulation by chemotherapeutic agent. J Surg Oncol 2002; 79: 37-45.
    • (2002) J Surg Oncol , vol.79 , pp. 37-45
    • Mitsui, A.1    Kuwabara, Y.2    Iwase, H.3
  • 8
    • 52049099166 scopus 로고    scopus 로고
    • Treatment of radioresistant stem-like esophageal cancer cells by an apoptotic gene-armed, telomerase-specific oncolytic adenovirus
    • Zhang X, Komaki R, Wang L, et al,. Treatment of radioresistant stem-like esophageal cancer cells by an apoptotic gene-armed, telomerase-specific oncolytic adenovirus. Clin Cancer Res 2008; 14: 2813-2823.
    • (2008) Clin Cancer Res , vol.14 , pp. 2813-2823
    • Zhang, X.1    Komaki, R.2    Wang, L.3
  • 9
    • 0033822365 scopus 로고    scopus 로고
    • Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing RT
    • Wong KK, Chang S, Weiler SR, et al,. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing RT. Nature Genet 2000; 26: 85-88.
    • (2000) Nature Genet , vol.26 , pp. 85-88
    • Wong, K.K.1    Chang, S.2    Weiler, S.R.3
  • 10
    • 70949097385 scopus 로고    scopus 로고
    • Role of telomere dysfunction in aging and its detection by biomarkers
    • von Figura G, Hartmann D, Song Z, et al,. Role of telomere dysfunction in aging and its detection by biomarkers. J Mol Med (Berl) 2009; 87: 1165-1171.
    • (2009) J Mol Med (Berl) , vol.87 , pp. 1165-1171
    • Von Figura, G.1    Hartmann, D.2    Song, Z.3
  • 11
    • 0035798379 scopus 로고    scopus 로고
    • The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
    • Zhou XZ, Lu KP,. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 2001; 107: 347-359.
    • (2001) Cell , vol.107 , pp. 347-359
    • Zhou, X.Z.1    Lu, K.P.2
  • 12
    • 33846170040 scopus 로고    scopus 로고
    • Characterization of a novel effect of hPinX1 on hTERT nucleolar localization
    • Lin J, Jin R, Zhang B, et al,. Characterization of a novel effect of hPinX1 on hTERT nucleolar localization. Biochem Biophys Res Commun 2007; 353: 946-952.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 946-952
    • Lin, J.1    Jin, R.2    Zhang, B.3
  • 13
    • 69249133796 scopus 로고    scopus 로고
    • PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation
    • Yuan K, Li N, Jiang K, et al,. PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. J Biol Chem 2009; 284: 23072-23082.
    • (2009) J Biol Chem , vol.284 , pp. 23072-23082
    • Yuan, K.1    Li, N.2    Jiang, K.3
  • 14
    • 58249097056 scopus 로고    scopus 로고
    • Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells
    • Zhang B, Bai YX, Ma HH, et al,. Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells. Cancer Res 2009; 69: 75-83.
    • (2009) Cancer Res , vol.69 , pp. 75-83
    • Zhang, B.1    Bai, Y.X.2    Ma, H.H.3
  • 15
    • 84855343604 scopus 로고    scopus 로고
    • Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation
    • Zhang B, Qian D, Ma HH, et al,. Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation. Oncogene 2012; 31: 1-12.
    • (2012) Oncogene , vol.31 , pp. 1-12
    • Zhang, B.1    Qian, D.2    Ma, H.H.3
  • 16
    • 77953444201 scopus 로고    scopus 로고
    • High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy
    • He LR, Liu MZ, Li BK, et al. High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Int J Cancer 2010; 127: 138-147.
    • (2010) Int J Cancer , vol.127 , pp. 138-147
    • He, L.R.1    Liu, M.Z.2    Li, B.K.3
  • 17
    • 77954153940 scopus 로고    scopus 로고
    • Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma
    • Cai MY, Zhang B, He WP, et al,. Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma. Cancer Sci 2010; 101: 1543-1549.
    • (2010) Cancer Sci , vol.101 , pp. 1543-1549
    • Cai, M.Y.1    Zhang, B.2    He, W.P.3
  • 18
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H, Smogorzewska A, de Lange T,. DNA damage foci at dysfunctional telomeres. Curr Biol 2003; 13: 1549-1556.
    • (2003) Curr Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    De Lange, T.3
  • 19
    • 12444317701 scopus 로고    scopus 로고
    • Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma
    • Akiyama Y, Maesawa C, Wada K, et al,. Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma. Oncol Rep 2004; 11: 871-874.
    • (2004) Oncol Rep , vol.11 , pp. 871-874
    • Akiyama, Y.1    Maesawa, C.2    Wada, K.3
  • 20
    • 3943095351 scopus 로고    scopus 로고
    • Mutational analysis of PINX1 in hereditary prostate cancer
    • Hawkins GA, Chang BL, Zheng SL, et al,. Mutational analysis of PINX1 in hereditary prostate cancer. Prostate 2004; 60: 298-302.
    • (2004) Prostate , vol.60 , pp. 298-302
    • Hawkins, G.A.1    Chang, B.L.2    Zheng, S.L.3
  • 21
    • 12444313020 scopus 로고    scopus 로고
    • Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
    • Kondo T, Oue N, Mitani Y, et al,. Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. Oncogene 2005; 24: 157-164.
    • (2005) Oncogene , vol.24 , pp. 157-164
    • Kondo, T.1    Oue, N.2    Mitani, Y.3
  • 22
    • 1242342026 scopus 로고    scopus 로고
    • Molecular analysis of PinX1 in medulloblastomas
    • Chang Q, Pang JC, Li J, et al,. Molecular analysis of PinX1 in medulloblastomas. Int J Cancer 2004; 109: 309-314.
    • (2004) Int J Cancer , vol.109 , pp. 309-314
    • Chang, Q.1    Pang, J.C.2    Li, J.3
  • 23
    • 79953306829 scopus 로고    scopus 로고
    • The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice
    • Zhou XZ, Huang P, Shi R, et al,. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest 2011; 121: 1266-1282.
    • (2011) J Clin Invest , vol.121 , pp. 1266-1282
    • Zhou, X.Z.1    Huang, P.2    Shi, R.3
  • 24
    • 34250841785 scopus 로고    scopus 로고
    • Replication and protection of telomeres
    • Verdun RE, Karlseder J,. Replication and protection of telomeres. Nature 2007; 447: 924-931.
    • (2007) Nature , vol.447 , pp. 924-931
    • Verdun, R.E.1    Karlseder, J.2
  • 25
    • 34247860915 scopus 로고    scopus 로고
    • Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
    • Cosme-Blanco W, Shen MF, Lazar AJ, et al,. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep 2007; 8: 497-503.
    • (2007) EMBO Rep , vol.8 , pp. 497-503
    • Cosme-Blanco, W.1    Shen, M.F.2    Lazar, A.J.3
  • 26
    • 77949352905 scopus 로고    scopus 로고
    • Telomere shortening sensitizes cancer cells to selected cytotoxic agents: In vitro and in vivo studies and putative mechanisms
    • Uziel O, Beery E, Dronichev V, et al,. Telomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanisms. PLoS One 2010; 5: e9132.
    • (2010) PLoS One , vol.5
    • Uziel, O.1    Beery, E.2    Dronichev, V.3
  • 27
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang X, Mar V, Zhou W, et al,. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 1999; 13: 2388-2399.
    • (1999) Genes Dev , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3
  • 28
    • 34848869763 scopus 로고    scopus 로고
    • Cell cycle disturbances and mitotic catastrophes in HeLa Hep2 cells following 2.5 to 10 Gy of ionizing RT
    • Eriksson D, Lofroth PO, Johansson L, et al,. Cell cycle disturbances and mitotic catastrophes in HeLa Hep2 cells following 2.5 to 10 Gy of ionizing RT. Clin Cancer Res 2007; 13: 5501s-5508s.
    • (2007) Clin Cancer Res , vol.13
    • Eriksson, D.1    Lofroth, P.O.2    Johansson, L.3
  • 29
    • 77954641944 scopus 로고    scopus 로고
    • RT-induced cell death mechanisms
    • Eriksson D, Stigbrand T,. RT-induced cell death mechanisms. Tumour Biol 2010; 31: 363-372.
    • (2010) Tumour Biol , vol.31 , pp. 363-372
    • Eriksson, D.1    Stigbrand, T.2
  • 30
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson IB, Broude EV, Chang BD,. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 2001; 4: 303-313.
    • (2001) Drug Resist Updat , vol.4 , pp. 303-313
    • Roninson, I.B.1    Broude, E.V.2    Chang, B.D.3
  • 31
    • 12844274301 scopus 로고    scopus 로고
    • DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint
    • Huang X, Tran T, Zhang L, et al,. DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci U S A 2005; 102: 1065-1070.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1065-1070
    • Huang, X.1    Tran, T.2    Zhang, L.3
  • 32
    • 65549127827 scopus 로고    scopus 로고
    • Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following RT-induced mitotic catastrophe
    • Ianzini F, Kosmacek EA, Nelson ES, et al,. Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following RT-induced mitotic catastrophe. Cancer Res 2009; 69: 2296-2304.
    • (2009) Cancer Res , vol.69 , pp. 2296-2304
    • Ianzini, F.1    Kosmacek, E.A.2    Nelson, E.S.3
  • 33
    • 84864607108 scopus 로고    scopus 로고
    • TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends
    • Zhong FL, Batista LF, Freund A, et al,. TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell 2012; 150: 481-494.
    • (2012) Cell , vol.150 , pp. 481-494
    • Zhong, F.L.1    Batista, L.F.2    Freund, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.