MYCN Transgenic Zebrafish Model with the Characterization of Acute Myeloid Leukemia and Altered Hematopoiesis

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Shen, Li Jing ^a   Chen, Fang Yuan ^a   Zhang, Yong ^a   Cao, Lan Fang ^a   Kuang, Ying ^b   Zhong, Min ^a   Wang, Ting ^a   Zhong, Hua ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Research Center for Biomodel Organism   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LIM ONLY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; N MYC DOWNSTREAM REGULATED GENE 1 PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR TAL1; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLAST CELL; BONE MARROW CELL; CELL CYCLE PROGRESSION; CELL FATE; CELL MATURATION; CELL PROLIFERATION; DOWN REGULATION; EMBRYO; FEMALE; GENE CONTROL; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC STABILITY; GERM LINE; GLUCONEOGENESIS; GLYCOLYSIS; HEMATOPOIESIS; KIDNEY PARENCHYMA; MALE; MALIGNANT TRANSFORMATION; MISMATCH REPAIR; MOLECULAR PATHOLOGY; MYELOPOIESIS; NEUTROPHIL; NONHUMAN; ONCOGENE C MYB; SPLEEN; TRANSGENIC ANIMAL; UPREGULATION; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD CELLS; CELL CYCLE; CELL LINEAGE; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; GENES, MYC; GENETIC VECTORS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MICE; MYELOID CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZEBRAFISH;

EID: 84875042557     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059070     Document Type: Article

References (47)

1. Rinaldi A, Mian M, Kwee I, Rossi D, Deambrogi C, et al. (2011) Genome-wide DNA profiling better defines the prognosis of chronic lymphocytic leukaemia. Br J Haematol 154: 590-599.
2. Scandurra M, Rossi D, Deambrogi C, Rancoita PM, Chigrinova E, et al. (2010) Genomic profiling of Richter's syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomas. Hematol Oncol 28: 62-67.
3. Lin YW, Beharry ZM, Hill EG, Song JH, Wang W, et al. (2010) A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood 115: 824-833.
4. Kawagoe H, Kandilci A, Kranenburg TA, Grosveld GC, (2007) Overexpression of N-Myc rapidly causes acute myeloid leukemia in mice. Cancer Res 67: 10677-10685.
5. Beckmann RP, Lovett M, Welch WJ, (1992) Examining the function and regulation of hsp 70 in cells subjected to metabolic stress. J Cell Biol 117: 1137-1150.
6. Halloran MC, Sato-Maeda M, Warren JT, Su F, Lele Z, et al. (2000) Laser-induced gene expression in specific cells of transgenic zebrafish. Development 127: 1953-1960.
7. Thermes V, Grabher C, Ristoratore F, Bourrat F, Choulika A, et al. (2002) I-SceI meganuclease mediates highly efficient transgenesis in fish. Mech Dev 118: 91-98.
8. Shafizadeh E, Paw BH, (2004) Zebrafish as a model of human hematologic disorders. Curr Opin Hematol 11: 255-261.
9. Paik EJ, Zon LI, (2010) Hematopoietic development in the zebrafish. Int J Dev Biol 54: 1127-1137.
10. Yeh JR, Munson KM, Chao YL, Peterson QP, Macrae CA, et al. (2008) AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development 135: 401-410.
11. Liao EC, Paw BH, Oates AC, Pratt SJ, Postlethwait JH, et al. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev 12: 621-626.
12. Rhodes J, Hagen A, Hsu K, Deng M, Liu TX, et al. (2005) Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Dev Cell 8: 97-108.
13. He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, et al. (2006) Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 125: 929-941.
14. Wu H, Li P, Shao N, Ma J, Ji M, et al. (2012) Aberrant expression of Treg-associated cytokine IL-35 along with IL-10 and TGF-beta in acute myeloid leukemia. Oncol Lett 3: 1119-1123.
15. Chen Q, Xie W, Kuhn DJ, Voorhees PM, Lopez-Girona A, et al. (2008) Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 111: 4690-4699.
16. Milella M, Kornblau SM, Estrov Z, Carter BZ, Lapillonne H, et al. (2001) Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 108: 851-859.
17. Meyer M, Rubsamen D, Slany R, Illmer T, Stabla K, et al. (2009) Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy. PLoS One 4: e7768.
18. Ng KP, Ebrahem Q, Negrotto S, Mahfouz RZ, Link KA, et al. (2011) p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia 25: 1739-1750.
19. Bell E, Premkumar R, Carr J, Lu X, Lovat PE, et al. (2006) The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage. Cell Cycle 5: 2639-2647.
20. Delgado MD, Leon J, (2010) Myc roles in hematopoiesis and leukemia. Genes Cancer 1: 605-616.
21. Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, et al. (2008) Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3: 611-624.
22. Wilson A, Murphy MJ, Oskarsson T, Kaloulis K, Bettess MD, et al. (2004) c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 18: 2747-2763.
23. Patterson LJ, Gering M, Eckfeldt CE, Green AR, Verfaillie CM, et al. (2007) The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood 109: 2389-2398.
24. Dooley KA, Davidson AJ, Zon LI, (2005) Zebrafish scl functions independently in hematopoietic and endothelial development. Dev Biol 277: 522-536.
25. El OK, Hoosdally SJ, Tuladhar K, Karia D, Vyas P, et al. (2011) Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex. Blood 117: 2146-2156.
26. Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, et al. (2011) RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element. EMBO J 30: 4059-4070.
27. Kissa K, Herbomel P, (2010) Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature 464: 112-115.
28. Acosta JC, Ferrandiz N, Bretones G, Torrano V, Blanco R, et al. (2008) Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest. Mol Cell Biol 28: 7286-7295.
29. Tschan MP, Shan D, Laedrach J, Eyholzer M, Leibundgut EO, et al. (2010) NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Leuk Res 34: 393-398.
30. Sun W, Shen WW, Yang S, Hu F, Gao Y, et al. (2010) Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes. J Biomed Sci 17: 22.
31. de Boer J, Yeung J, Ellu J, Ramanujachar R, Bornhauser B, et al. (2011) The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors. Leukemia 25: 321-330.
32. Sheppard RD, Samant SA, Rosenberg M, Silver LM, Cole MD, (1998) Transgenic N-myc mouse model for indolent B cell lymphoma: tumor characterization and analysis of genetic alterations in spontaneous and retrovirally accelerated tumors. Oncogene 17: 2073-2085.
33. Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, et al. (2005) Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 102: 6068-6073.
34. Akers LJ, Fang W, Levy AG, Franklin AR, Huang P, et al. (2011) Targeting glycolysis in leukemia: a novel inhibitor 3-BrOP in combination with rapamycin. Leuk Res 35: 814-820.
35. Bell E, Lunec J, Tweddle DA, (2007) Cell cycle regulation targets of MYCN identified by gene expression microarrays. Cell Cycle 6: 1249-1256.
36. Sugihara E, Kanai M, Saito S, Nitta T, Toyoshima H, et al. (2006) Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Res 66: 4020-4029.
37. Bajoghli B, Aghaallaei N, Heimbucher T, Czerny T, (2004) An artificial promoter construct for heat-inducible misexpression during fishembryogenesis. Dev Biol 271: 416-430.
38. Cunniff NF, Morgan WD, (1993) Analysis of heat shock element recognition by saturation mutagenesis of the human HSP70.1 gene promoter. J Biol Chem 268: 8317-8324.
39. Westerfield M. 1995. The zebrafish book: a guide for the laboratoryuse of zebrafish (Danio rerio). pp. 1.1-1.27. University of Oregon Press, Eugene.
40. Fujimori H, Asahina K, Shimizu-Saito K, Ikeda R, Tanaka Y, et al. (2008) Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells. J Hepatol 48: 962-973.
41. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR andthe 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
42. Le HY, Zhang Y, Liu H, Ma LH, Jin Y, et al. (2008) eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation inzebrafish. J Biol Chem 283: 17652-17661.
43. Jagadeeswaran P, Sheehan JP, Craig FE, Troyer D, (1999) Identification and characterization of zebrafish thrombocytes. Br J Haematol 107: 731-738.
44. Rowley AF, Hill DJ, Ray CE, Munro R, (1997) Haemostasis in fish--an evolutionary perspective. Thromb Haemost 77: 227-233.
45. Gupta T, Mullins MC (2010) Dissection of organs from the adult zebrafish.LID- 10.3791/1717 [doi]LID- 1717 [pii]. J Vis Exp.
46. Chen J, Jette C, Kanki JP, Aster JC, Look AT, et al. (2007) NOTCH1-induced T-cell leukemia in transgenic zebrafish. Leukemia 21: 462-471.
47. Huang W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.