Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  Botelho, Patrícia Borges ^a   Mariano, Karina Da Rocha ^a   Rogero, Marcelo MacEdo ^a   De Castro, Inar Alves ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Atherosclerosis; Echium; Inflammation; Omega 3; Stearidonic; Steatosis

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; CHOLESTEROL; DOCOSAHEXAENOIC ACID; ECHIUM OIL; FISH OIL; HIGH DENSITY LIPOPROTEIN; ICOSAPENTAENOIC ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LINOLENIC ACID; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEARIDONIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LOW DENSITY LIPOPROTEIN; WATER;

ALGA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; ECHIUM; FATTY LIVER; FEEDING; FISH; KNOCKOUT MOUSE; LIPID DIET; LIPID LIVER LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER HISTOLOGY; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ALPHA-LINOLENIC ACID; ANIMALS; CHLOROPHYTA; CHOLESTEROL; DIET, HIGH-FAT; DIETARY FATS, UNSATURATED; DOCOSAHEXAENOIC ACIDS; ECHIUM; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; FATTY LIVER; FISHES; GENE EXPRESSION; LIPID METABOLISM; LIPOPROTEINS, HDL; LIVER; MALE; MICE; MICE, KNOCKOUT; ORPHAN NUCLEAR RECEPTORS; PPAR ALPHA; RECEPTORS, LDL; TRIGLYCERIDES;

ALGAE; ANIMALIA; ECHIUM; MUS;

EID: 84875037267     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-38     Document Type: Article

References (30)

1. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Blasbalg TL, Hibbeln JR, Ramsden CE, Majchrzak SF, Rawlings RR, Am J Clin Nutr 2011 93 950 62 10.3945/ajcn.110.006643 21367944
2. The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease. Shapiro H, Tehilla M, Attal-Singer J, Bruck R, Luzzatti R, Singer P, Clin Nutr 2011 30 6 19 10.1016/j.clnu.2010.06.001 20619513
3. Mechanisms by which botanical lipids affect inflammatory disorders. Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC, Am J Clin Nutr 2008 87 498S 503S 18258646
4. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J, Atherosclerosis 2006 189 19 30 10.1016/j.atherosclerosis.2006.02.012 16530201
5. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. Adkins Y, Kelley DS, J Nutr Biochem 2010 21 781 92 10.1016/j.jnutbio.2009.12.004 20382009
6. Food and Drug Administration, Office of nutritional products, labeling, and dietary supplements, center for food safety and applied nutrition, US food and drug administration. Omega-3 fatty acids & coronary heart disease Docket No. 2003Q-0401. http://www.fda.gov/Food/GuidanceRegulation/ GuidanceDocumentsRegulatoryInformation/LabelingNutrition/ucm064923.htm. Accessed February 27, 2013
7. Fish comsumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Kris-Etherton PM, Harris WS, Appel LJ, Circulation 2002 106 2747 57 10.1161/01.CIR.0000038493.65177.94 12438303
8. n-3 Fatty acids from fish or fish-oil supplements, but not α-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, Jordan HS, Lau J, Am J Clin Nutr 2006 84 5 17 16825676
9. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Barceló-Coblijn G, Murphy EJ, Prog Lipid Res 2009 48 355 74 10.1016/j.plipres.2009.07.002 19619583
10. Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety. Lemke SL, Vicini JL, Su H, Goldstein DA, Nemeth MA, Krul ES, Harris WS, Am J Clin Nutr 2010 92 766 75 10.3945/ajcn.2009.29072 20739419
11. An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Venegas-Calerón M, Sayanova O, Napier JA, Prog Lipid Res 2010 49 108 19 10.1016/j.plipres.2009. 10.001 19857520
12. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. Poudyal H, Panchal SK, Diwan V, Brown L, Prog Lipid Res 2011 50 372 87 10.1016/j.plipres.2011.06.003 21762726
13. Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. Tahvonen RL, Schwab US, Linderborg KM, Mykkänen HM, Kallio HP, J Nutr Biochem 2005 16 353 9 10.1016/j.jnutbio.2005.01.004 15936647
14. Engineering oilseed plants for a sustainable, land-based source of long chain polyunsaturated fatty acids. Damude HG, Kinney AJ, Lipids 2007 42 179 85 10.1007/s11745-007-3049-1 17393224
15. Comparison of the conversion rates of alpha-linolenic acid (18:3(n-3)) and stearidonic acid (18:4(n-3)) to longer polyunsaturated fatty acids in rats. Yamazaki K, Fujikawa M, Hamazaki T, Yano S, Shono T, Biochim Biophys Acta 1992 1123 18 26 10.1016/0005-2760(92)90166-S 1346092
16. Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits. Whelan J, J Nutr 2009 139 5 10 19056654
17. Official methods n. 996.06, Fat (Total, Saturated, and Monounsaturated) in Foods. AOAC, Offic Meth Anal 2002 41 20 24A
18. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Friedewald WT, Levy RI, Fredrickson DS, Clin Chem 1972 18 499 502 4337382
19. Quality control of three methods for lung tumorigenesis studies. Tillmann T, Kamino K, Dasenbrock C, Kohler M, Morawietz G, Campo E, Cardesa A, Tomatis L, Mohr U, Exp Toxicol Pathol 1999 51 99 104 10.1016/S0940-2993(99)80078-5 10048721
20. Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice. Zhang P, Boudyguina E, Wilsom MD, Gebre AK, Parks JS, J Nutr Biochem 2008 19 655 63 10.1016/j.jnutbio.2007.08.005 18155507
21. Stearidonic acid-enhaced soybean oil: a plant-based source of n-3 fatty acids for foods. Harris WS, J Nutr 2012 142 600S 604S 10.3945/jn.111.146613 22279144
22. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, Sekiya M, Takahashi A, Hasty AH, Sato R, Sone H, Osuga J, Ishibashi S, Yamada N, Mol Endocrinol 2003 17 1240 54 10.1210/me.2002-0190 12730331
23. Fatty liver: role of inflammation and fatty acid nutrition. Byrne CD, Prostaglandins Leukot Essent Fatty Acids 2010 82 265 71 10.1016/j.plefa.2010.02. 012 20189787
24. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ, Atherosclerosis 2008 197 12 24 10.1016/j.atherosclerosis.2007.11.008 18160071
25. Effects of dietary stearidonic acid on biomarkers of lipid metabolism. Whelan J, Gouffon J, Zhao Y, J Nutr 2012 142 630S 634S 10.3945/jn.111.149138 22279143
26. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. Parker HM, Johnson NA, Burdon CA, Cohn JS, O' Connor HT, George J, J Hepatol 2012 56 944 951 10.1016/j.jhep.2011.08.018 22023985
27. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, Nagai R, Ishibashi S, Osuga J, Yamada N, Shimano H, Hepatology 2003 38 1529 1539 14647064
28. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, Poniachik J, Clin Sci 2004 106 635 643 10.1042/CS20030326 14720121
29. Comparison of the effects of dietary α- Linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice. Ishihara K, Komatsu W, Saito H, Shinohara K, Lipids 2002 37 481 6 10.1007/s11745-002-0921-3 12056590
30. Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect? Safwat GM, Pisanò S, D'Amore E, Borioni G, Napolitano M, Kamal AA, Ballanti P, Botham KM, Bravo E, Nutrition 2009 25 1157 68 10.1016/j.nut.2009.02.009 19592219