Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 5, Issue 1, 2013, Pages 11-20

  Gu, Haigang ^a   Yu, Shan Ping ^a   Gutekunst, Claire Anne ^a   Gross, Robert E ^a,b   Wei, Ling ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Emory University   (United States)

Author keywords

Myelin; Neural stem cells; Neurite outgrowth; Neuronal differentiation; Rho signaling pathway

Indexed keywords

3 (4, 5 DIMETHYL 2 THIAZOLYL) 2, 5 DIPHENYLTETRAZOLIUM BROMIDE; EXOENZYME C3; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN; POLY DEXTRO LYSINE; PROTEIN KINASE B; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEURAL STEM CELL; NEWBORN; NONHUMAN; PATCH CLAMP; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBVENTRICULAR ZONE; UPREGULATION; WESTERN BLOTTING;

EID: 84875034648     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Gage FH. Mammalian neural stem cells. Science 2000; 287: 1433-1438.
2. Song HJ, Stevens CF and Gage FH. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci 2002; 5: 438-445.
3. Taupin P. Adult neural stem cells, neurogenic niches, and cellular therapy. Stem Cell Rev 2006; 2: 213-219.
4. Bithell A and Williams BP. Neural stem cells and cell replacement therapy: making the right cells. Clin Sci (Lond) 2005; 108: 13-22.
5. Ming GL and Song H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 2011; 70: 687-702.
6. Lunn JS, Sakowski SA, Hur J and Feldman EL. Stem cell technology for neurodegenerative diseases. Ann Neurol 2011; 70: 353-361.
7. Wei L, Keogh CL, Whitaker VR, Theus MH and Yu SP. Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke. Pathophysiology 2005; 12: 47-62.
8. Xu X, Warrington AE, Bieber AJ and Rodriguez M. Enhancing CNS repair in neurological disease: challenges arising from neurodegeneration and rewiring of the network. CNS Drugs 2011; 25: 555-573.
9. Yoneyama M, Shiba T, Hasebe S and Ogita K. Adult neurogenesis is regulated by endogenous factors produced during neurodegeneration. J Pharmacol Sci 2011; 115: 425-432.
10. Lichtenwalner RJ and Parent JM. Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab 2006; 26: 1-20.
11. Kokaia Z and Lindvall O. Neurogenesis after ischaemic brain insults. Curr Opin Neurobiol 2003; 13: 127-132.
12. Skaper SD. Neuronal growth-promoting and inhibitory cues in neuroprotection and neuroregeneration. Ann N Y Acad Sci 2005; 1053: 376-385.
13. Mellough CB, Cho S, Wood A and Przyborski S. Neurite formation by neurons derived from adult rat hippocampal progenitor cells is susceptible to myelin inhibition. Neurochem Int 2011; doi:10.1016/j.neuint.2011.1001.1015.
14. Schmandke A and Strittmatter SM. ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist 2007; 13: 454-469.
15. Liao JK, Seto M and Noma K. Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol 2007; 50: 17-24.
16. Kubo T, Hata K, Yamaguchi A and Yamashita T. Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr Pharm Des 2007; 13: 2493-2499.
17. Yuan XB, Jin M, Xu X, Song YQ, Wu CP, Poo MM and Duan S. Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nat Cell Biol 2003; 5: 38-45.
18. Fournier AE, Takizawa BT and Strittmatter SM. Rho kinase inhibition enhances axonal regeneration in the injured CNS. J Neurosci 2003; 23: 1416-1423.
19. Gallo G and Letourneau PC. Regulation of growth cone actin filaments by guidance cues. J Neurobiol 2004; 58: 92-102.
20. Niederost B, Oertle T, Fritsche J, McKinney RA and Bandtlow CE. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J Neurosci 2002; 22: 10368-10376.
21. Xuan AG, Long DH, Gu HG, Yang DD, Hong LP and Leng SL. BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbriafornix. Neurosci Lett 2008; 440: 331-335.
22. Lingor P, Teusch N, Schwarz K, Mueller R, Mack H, Bahr M and Mueller BK. Inhibition of Rho kinase (ROCK) increases neurite out-growth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J Neurochem 2007; 103: 181-189.
23. Wei L, Cui L, Snider BJ, Rivkin M, Yu SS, Lee CS, Adams LD, Gottlieb DI, Johnson EM Jr, Yu SP and Choi DW. Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. Neurobiol Dis 2005; 19: 183-193.
24. Li X, Krawetz R, Liu S, Meng G and Rancourt DE. ROCK inhibitor improves survival of cryo-preserved serum/feeder-free single human embryonic stem cells. Hum Reprod 2009; 24: 580-589.
25. Kamata Y and Hattori Y. Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation. J Vet Med Sci 2007; 69: 37-42.
26. Watanabe Y, Morimatsu M and Syuto B. The evaluation of the potential of botulinum C3 enzyme as an exogenous differentiation inducing factor to neurons. J Vet Med Sci 2000; 62: 473-478.
27. Sandvig A, Berry M, Barrett LB, Butt A and Logan A. Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Glia 2004; 46: 225-251.
28. McGee AW and Strittmatter SM. The Nogo-66 receptor: focusing myelin inhibition of axon regeneration. Trends Neurosci 2003; 26: 193-198.
29. Hirose M, Ishizaki T, Watanabe N, Uehata M, Kranenburg O, Moolenaar WH, Matsumura F, Maekawa M, Bito H and Narumiya S. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol 1998; 141: 1625-1636.
30. Lingor P, Tonges L, Pieper N, Bermel C, Barski E, Planchamp V and Bahr M. ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain 2008; 131: 250-263.
31. Li Z, Theus MH and Wei L. Role of ERK 1/2 signaling in neuronal differentiation of cultured embryonic stem cells. Dev Growth Differ 2006; 48: 513-523.