Environmental toxicants as extrinsic epigenetic factors for Parkinsonism: Studies employing transgenic C. elegans model

CNS and Neurological Disorders - Drug Targets

Volumn 11, Issue 8, 2012, Pages 976-983

  Jadiya, Pooja ^a   Nazir, Aamir ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

synuclein; Caenorhabditis elegans; Parkinson's disease; Pesticides

Indexed keywords

ALDICARB; ALPHA SYNUCLEIN; CHLORPYRIFOS; CIPERMETHRIN; FOLPET; PARAQUAT; PESTICIDE; REACTIVE OXYGEN METABOLITE; ROTENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; FLUORESCENCE MICROSCOPY; LIPID ANALYSIS; MITOCHONDRIAL VOLUME; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSONISM; PROTEIN AGGREGATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; ENVIRONMENTAL POLLUTANTS; EPIGENESIS, GENETIC; HUMANS; PARKINSON DISEASE, SECONDARY;

EID: 84875024696     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527311211080006     Document Type: Article

References (39)

1. Vance, J.M.; Ali, S.; Bradley, W.G.; Singer, C.; Di Monte, D.A. Geneenvironment interactions in Parkinson's disease and other forms of parkinsonism. Neurotoxicology, 2010, 31(5), 598-602.
2. Bekris, L.M.; Mata, I.F.; Zabetian, C.P. The genetics of Parkinson disease. J. Geriatr. Psychiatry Neurol., 2010, 23(4), 228-242.
3. Kim, S.N.; Doo, A.R.; Park, J.Y.; Bae, H.; Chae, Y.; Shim, I.; Lee, H.; Moon, W.; Park, H.J. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PLoS One, 2011, 6(11), e27566.
4. Forloni, G.; Bertani, I.; Calella, A.M.; Thaler, F.; Invernizzi, R. Alphasynuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Ann. Neurol., 2000, 47(5), 632-640.
5. Parron, T.; Requena, M.; Hernandez, A.F.; Alarcon, R. Association between environmental exposure to pesticides and neurodegenerative diseases. Toxicol. Appl. Pharmacol., 2011, 256(3), 379-385.
6. Hatcher, J.M.; Pennell, K.D.; Miller, G.W. Parkinson's disease and pesticides: a toxicological perspective. Trends Pharmacol. Sci., 2008, 29(6), 322-329.
7. Vinuela, A.; Snoek, L.B.; Riksen, J.A.; Kammenga, J.E. Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans. PLoS One, 2010, 5(8), e12145.
8. Ved, R.; Saha, S.; Westlund, B.; Perier, C.; Burnam, L.; Sluder, A.; Hoener, M.; Rodrigues, C.M.; Alfonso, A.; Steer, C.; Liu, L.; Przedborski, S.; Wolozin, B. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alphasynuclein, parkin, and DJ-1 in Caenorhabditis elegans. J. Biol. Chem., 2005, 280(52), 42655-42668.
9. Roh, J.Y.; Lee, J.; Choi, J. Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: a potential biomarker for metal-induced toxicity monitoring and environmental risk assessment. Environ. Toxicol. Chem., 2006, 25(11), 2946-2956.
10. Kaletta, T.; Hengartner, M.O. Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov., 2006, 5(5), 387-398.
11. Jadiya, P.; Chatterjee, M.; Sammi, S.R.; Kaur, S.; Palit, G.; Nazir, A. Sir-2.1 modulates 'calorie-restriction-mediated' prevention of neurodegeneration in Caenorhabditis elegans: implications for Parkinson's disease. Biochem. Biophys. Res. Commun., 2011, 413(2), 306-310.
12. Stiernagle, T. Maintenance of C. elegans. WormBook, 2006, 1-11.
13. Hosamani, R.; Muralidhara. Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster. Neurotoxicology, 2009, 30(6), 977-985.
14. Yang, W.; Hekimi, S. Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell, 2010, 9(3), 433-447.
15. Jones, D.; Stringham, E.G.; Babich, S.L.; Candido, E.P. Transgenic strains of the nematode C. elegans in biomonitoring and toxicology: effects of captan and related compounds on the stress response. Toxicology, 1996, 109(2-3), 119-127.
16. Roh, J.Y.; Choi, J. Ecotoxicological evaluation of chlorpyrifos exposure on the nematode Caenorhabditis elegans. Ecotoxicol. Environ. Saf., 2008, 71(2), 483-489.
17. Jadiya, P.; Khan, A.; Sammi, S.R.; Kaur, S.; Mir, S.S.; Nazir, A. Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease. Biochem. Biophys. Res. Commun., 2011, 413(4), 605-610.
18. Kaur, S.; Sammi, S.R.; Jadiya, P.; Nazir, A. RNAi of cat-2, a putative tyrosine hydroxylase, increases alpha synuclein aggregation and associated effects in transgenic C. elegans. CNS Neurol. Disord. Drug Targets, 2012, 11(4), 387-394.
19. Nazir, A.; Sammi, S.R.; Singh, P.; Tripathi, R.K. Trans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans. PLoS One, 2010, 5(12), e15312.
20. Artal-Sanz, M.; Tavernarakis, N. Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature, 2009, 461(7265), 793-797.
21. Ali, S.F.; Binienda, Z.K.; Imam, S.Z. Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction. Int. J. Environ. Res. Public Health, 2011, 8(12), 4702-4713.
22. Thiffault, C.; Langston, J.W.; Di Monte, D.A. Increased striatal dopamine turnover following acute administration of rotenone to mice. Brain Res., 2000, 885(2), 283-288.
23. Betarbet, R.; Sherer, T.B.; MacKenzie, G.; Garcia-Osuna, M.; Panov, A.V.; Greenamyre, J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci., 2000, 3(12), 1301-1306.
24. Snyder, S.H.; D'Amato, R.J. Predicting Parkinson's disease. Nature, 1985, 317(6034), 198-199.
25. Manning-Bog, A.B.; McCormack, A.L.; Li, J.; Uversky, V.N.; Fink, A.L.; Di Monte, D.A. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J. Biol. Chem., 2002, 277(3), 1641-1644.
26. McCormack, A.L.; Thiruchelvam, M.; Manning-Bog, A.B.; Thiffault, C.; Langston, J.W.; Cory-Slechta, D.A.; Di Monte, D.A. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol. Dis., 2002, 10(2), 119-127.
27. Azad, P.; Ryu, J.; Haddad, G.G. Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia. Free Radic. Biol. Med., 2011, 51(2), 530-538.
28. Karen, D.J.; Li, W.; Harp, P.R.; Gillette, J.S.; Bloomquist, J.R. Striatal dopaminergic pathways as a target for the insecticides permethrin and chlorpyrifos. Neurotoxicology, 2001, 22(6), 811-7.
29. Qiao, D.; Seidler, F.J.; Slotkin, T.A. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol. Appl. Pharmacol., 2005, 206(1), 17-26.
30. Kalender, Y.; Kaya, S.; Durak, D.; Uzun, F.G.; Demir, F. Protective effects of catechin and quercetin on antioxidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats. Environ. Toxicol. Pharmacol., 2012, 33(2), 141-148.
31. Casarett, L.J.; Doull, J.; Klaassen, C.D. Casarett and Doull's toxicology: the basic science of poisons. 6th ed. New York: McGraw-Hill Medical Pub. Division; 2001.
32. Wang, X.F.; Li, S.; Chou, A.P.; Bronstein, J.M. Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease. Neurobiol. Dis., 2006, 23(1), 198-205.
33. Ebrahimi-Fakhari, D.; McLean, P.J.; Unni, V.K. Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease. Autophagy, 2012, 8(2), 281-283.
34. Parihar, M.S.; Parihar, A.; Fujita, M.; Hashimoto, M.; Ghafourifar, P. Mitochondrial association of alpha-synuclein causes oxidative stress. Cell Mol. Life Sci., 2008, 65(7-8), 1272-1284.
35. Maran, E.; Fernandez, M.; Barbieri, P.; Font, G.; Ruiz, M.J. Effects of four carbamate compounds on antioxidant parameters. Ecotoxicol. Environ. Saf., 2009, 72(3), 922-930.
36. Maran, E.; Fernandez-Franzon, M.; Font, G.; Ruiz, M.J. Effects of aldicarb and propoxur on cytotoxicity and lipid peroxidation in CHOK1 cells. Food Chem. Toxicol., 2010, 48(6), 1592-1596.
37. Verschoyle, R.D.; Aldridge, W.N. Structure-activity relationships of some pyrethroids in rats. Arch. Toxicol., 1980, 45(4), 325-329.
38. Costa, L.G.; Giordano, G.; Guizzetti, M.; Vitalone, A. Neurotoxicity of pesticides: a brief review. Front. Biosci., 2008, 13, 1240-1249.
39. Tiwari, M.N.; Singh, A.K.; Ahmad, I.; Upadhyay, G.; Singh, D.; Patel, D.K.; Singh, C.; Prakash, O.; Singh, M.P. Effects of cypermethrin on monoamine transporters, xenobiotic metabolizing enzymes and lipid peroxidation in the rat nigrostriatal system. Free Radic. Res., 2010, 44(12), 1416-1424.