Contact lenses: Promising devices for ocular drug delivery

Journal of Ocular Pharmacology and Therapeutics

Volumn 29, Issue 2, 2013, Pages 189-199

  Guzman Aranguez, Ana ^a   Colligris, Basilio ^a   Pintor, Jesús ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; ALPHA TOCOPHEROL; CIPROFLOXACIN; CYCLOSPORIN A; DEXAMETHASONE; DICLOFENAC; EPIDERMAL GROWTH FACTOR; ETHOXZOLAMIDE; HYALURONIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; INSULIN; KETOTIFEN FUMARATE; LEVOFLOXACIN; LIDOCAINE; LIPOSOME; NANOPARTICLE; NORFLOXACIN; OXPRENOLOL; PILOCARPINE; PREDNISOLONE; TIMOLOL;

ALLERGIC CONJUNCTIVITIS; BACTERIAL KERATITIS; BIOAVAILABILITY; CONTACT LENS; CORNEA DYSTROPHY; CORNEA EDEMA; CORNEA EROSION; CORNEA INJURY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUTION; DRY EYE; ENDOPHTHALMITIS; EYE ALLERGY; GLASS TRANSITION TEMPERATURE; GLAUCOMA; HUMAN; HYDROGEL; HYDROPHILIC CONTACT LENS; INTRAOCULAR DRUG ADMINISTRATION; MICROEMULSION; MOLECULAR IMPRINTING; NONHUMAN; PHASE 3 CLINICAL TRIAL (TOPIC); POLYMERIZATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SOFT CONTACT LENS; VERNAL CONJUNCTIVITIS; WATER CONTENT; WETTABILITY;

ADMINISTRATION, OPHTHALMIC; ANIMALS; CONTACT LENSES; DRUG DELIVERY SYSTEMS; EYE DISEASES; FEASIBILITY STUDIES; HUMANS; OPHTHALMIC SOLUTIONS;

EID: 84875021348     PISSN: 10807683     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.2012.0212     Document Type: Review

References (97)

1. Ghate, D., & Edelhauser, H.F. Ocular drug delivery. Expert Opin. Drug Deliv. 3:275-287, 2006.
2. Lang, J.C. Ocular drug-delivery conventional ocular formulations. Adv. Drug Deliver. Rev. 16:39-43, 1995.
3. Akahane, K., Kato, M., & Takayama, S. Involvement of inhibitory and excitatory neurotransmitters in levofloxacinand ciprofloxacin-induced convulsions in mice. Antimicrob. Agents Chemother. 37:1764-1770, 1993.
4. Lomaestro, B.M. Fluoroquinolone-induced renal failure. Drug Saf. 22:479-485, 2000.
5. Schwartz, M.T., & Calvert, J.F. Potential neurologic toxicity related to ciprofloxacin. DICP. 24:138-140, 1990.
6. Frishman, W.H., Kowalski, M., Nagnur, S., Warshafsky, S., and Sica, D. Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-Adrenergic blockade. Heart Dis. 3:386-397, 2001.
7. Sklubalova, Z., & Zatloukal, Z. Systematic study of factors affecting eye drop size and dosing variability. Pharmazie. 60:917-921, 2005.
8. Sklubalova, Z., & Zatloukal, Z. Study of eye drops dispensing and dose variability by using plastic dropper tips. Drug Dev. Ind. Pharm. 32:197-205, 2006.
9. Gaudana, R., Ananthula, H.K., Parenky, A., & Mitra, A.K. Ocular drug delivery. AAPS J. 12:348-360, 2010.
10. Gaudana, R., Jwala, J., Boddu, S.H., & Mitra, A.K. Recent perspectives in ocular drug delivery. Pharm. Res. 26:1197-1216, 2009.
11. Kompella, U.B., Kadam, R.S., & Lee, V.H. Recent advances in ophthalmic drug delivery. Ther. Deliv. 1:435-456, 2010.
12. Novack, G.D. Ophthalmic drug delivery: development and regulatory considerations. Clin. Pharmacol. Ther. 85:539-543, 2009.
13. McNamara, N.A., Polse, K.A., Brand, R.J., Graham, A.D., Chan, J.S., & McKenney, C.D. Tear mixing under a soft contact lens: Effects of lens diameter. Am. J. Ophthalmol. 127:659-665, 1999.
14. Creech, J.L., Chauhan, A., & Radke, C.J. Dispersive mixing in the posterior tear film under a soft contact lens. Ind. Eng. Chem. Res. 40:3015-3026, 2001.
15. Li, C.C., & Chauhan, A. Modeling ophthalmic drug delivery by soaked contact lenses. Ind. Eng. Chem. Res. 45:3718-3734, 2006.
16. Ruben, M., & Watkins, R. Pilocarpine dispensation for the soft hydrophilic contact lens. Br. J. Ophthalmol. 59:455-458, 1975.
17. Jain, M.R. Drug delivery through soft contact lenses. Br. J. Ophthalmol. 72:150-154, 1988.
18. Li, C.C., & Chauhan, A. Ocular transport model for ophthalmic delivery of timolol through p-HEMA contact lenses. J. Drug Deliv. Sci. Tech. 17:69-79, 2007.
19. Kim, J., & Chauhan, A. Dexamethasone transport and ocular delivery from poly(hydroxyethyl methacrylate) gels. Int. J. Pharm. 353:205-222, 2008.
20. Karlgard, C.C., Wong, N.S., Jones, L.W., & Moresoli, C. In vitro uptake and release studies of ocular pharmaceutical agents by silicon-containing and p-HEMA hydrogel contact lens materials. Int. J. Pharm. 257:141-151, 2003.
21. Soluri, A., Hui, A., & Jones, L. Delivery of ketotifen fumarate by commercial contact lens materials. Optom. Vis. Sci. 89:1140-1149, 2012.
22. Winterton, L.C., Lally, J.M., Sentell, K.B., & Chapoy, L.L. The elution of poly (vinyl alcohol) from a contact lens: the realization of a time release moisturizing agent/artificial tear. J. Biomed. Mater. Res. B Appl. Biomater. 80:424-432, 2007.
23. Xu, J., Li, X., & Sun, F. In vitro and in vivo evaluation of ketotifen fumarate-loaded silicone hydrogel contact lenses for ocular drug delivery. Drug Deliv. 18:150-158, 2011.
24. Nakada, K., & Sugiyama, A. Process for producing controlled drug-release contact lens, and controlled drug-release contact lens thereby produced.US6027745 Patent, 1998.
25. Hull, D.S., Edelhauser, H.F., & Hyndiuk, R.A. Ocular penetration of prednisolone and the hydrophilic contact lens. Arch. Ophthalmol. 92:413-416, 1974.
26. Lesher, G.A., & Gunderson, G.G. Continuous drug delivery through the use of disposable contact lenses. Optom. Vis. Sci. 70:1012-1018, 1993.
27. Kim, J., Conway, A., & Chauhan, A. Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses. Biomaterials. 29:2259-2269, 2008.
28. Kim, J., Peng, C.C., & Chauhan, A. Extended release of dexamethasone from silicone-hydrogel contact lenses containing vitamin E. J. Control. Release. 148:110-116, 2010.
29. Peng, C.C., Burke, M.T., Carbia, B.E., Plummer, C., and Chauhan, A. Extended drug delivery by contact lenses for glaucoma therapy. J. Control. Release. 162:152-158, 2012.
30. Peng, C.C., Kim, J., & Chauhan, A. Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing vitamin E diffusion barriers. Biomaterials. 31: 4032-4047, 2010.
31. Uchida, R., Sato, T., Tanigawa, H., & Uno, K. Azulene incorporation and release by hydrogel containing methacrylamide propyltrimenthylammonium chloride, and its application to soft contact lens. J. Control. Release. 92:259-264, 2003.
32. Sato, T., Uchida, R., Tanigawa, H., Uno, K., & Murakami, A. Application of polymer gels containing side-chain phosphate groups to drug-delivery contact lenses. J. Appl. Polym. Sci. 98:731-735, 2005.
33. Ende, M.T.A., & Peppas, N.A. Transport of ionizable drugs and proteins in crosslinked poly(acrylic acid) and poly(acrylic acid-co-2- hydroxyethyl methacrylate) hydrogels .2. Diffusion and release studies. J. Control. Release. 48:47-56, 1997.
34. Brahim, S., Narinesingh, D., & Guiseppi-Elie, A. Release characteristics of novel pH-sensitive p(HEMA-DMAEMA) hydrogels containing 3-(trimethoxy-silyl) propyl methacrylate. Biomacromolecules. 4:1224-1231, 2003.
35. Andrade-Vivero, P., Fernandez-Gabriel, E., Alvarez-Lorenzo, C., & Concheiro, A. Improving the loading and release of NSAIDs from pHEMA hydrogels by copolymerization with functionalized monomers. J. Pharm. Sci. 96:802-813, 2007.
36. Gulsen, D., & Chauhan, A. Ophthalmic drug delivery through contact lenses. Invest. Ophthalmol. Vis. Sci. 45:2342-2347, 2004.
37. Gulsen, D., & Chauhan, A. Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle. Int. J. Pharm. 292:95-117, 2005.
38. Gulsen, D., Li, C.C., & Chauhan, A. Dispersion of DMPC liposomes in contact lenses for ophthalmic drug delivery. Curr. Eye Res. 30:1071-1080, 2005.
39. Kapoor, Y., & Chauhan, A. Ophthalmic delivery of cyclosporine A from Brij-97 microemulsion and surfactantladen p-HEMA hydrogels. Int. J. Pharm. 361:222-229, 2008.
40. Kapoor, Y., Thomas, J.C., Tan, G., John, V.T., & Chauhan, A. Surfactant-laden soft contact lenses for extended delivery of ophthalmic drugs. Biomaterials. 30:867-878, 2009.
41. Furrer, P., Mayer, J.M., Plazonnet, B., & Gurny, R. Ocular tolerance of absorption enhancers in ophthalmic preparations. AAPS Pharmsci. 4:6-10, 2002.
42. Saettone, M.F., Chetoni, P., Cerbai, R., Mazzanti, G., and Braghiroli, L. Evaluation of ocular permeation enhancers: in vitro effects on corneal transport of four beta-blockers, and in vitro in vivo toxic activity. Int. J. Pharm. 142:103-113, 1996.
43. Danion, A., Brochu, H., Martin, Y., & Vermette, P. Fabrication and characterization of contact lenses bearing surfaceimmobilized layers of intact liposomes. J. Biomed. Mater. Res. A. 82:41-51, 2007.
44. Danion, A., Doillon, C.J., Giasson, C.J., Djouahra, S., Sauvageau, P., Paradis, R., & Vermette, P. Biocompatibility and light transmission of liposomal lenses. Optom. Vis. Sci. 84:954-961, 2007.
45. Danion, A., Arsenault, I., & Vermette, P. Antibacterial activity of contact lenses bearing surface-immobilized layers of intact liposomes loaded with levofloxacin. J. Pharm. Sci. 96:2350-2363, 2007.
46. White, C.J., & Byrne, M.E. Molecularly imprinted therapeutic contact lenses. Expert Opin. Drug Deliv. 7:765-780, 2010.
47. Alvarez-Lorenzo, C., Hiratani, H., Gomez-Amoza, J.L., Martinez-Pacheco, R., Souto, C., & Concheiro, A. Soft contact lenses capable of sustained delivery of timolol. J. Pharm. Sci. 91:2182-2192, 2002.
48. Hiratani, H., Mizutani, Y., & Alvarez-Lorenzo, C. Controlling drug release from imprinted hydrogels by modifying the characteristics of the imprinted cavities. Macromol. Biosci. 5:728-733, 2005.
49. Alvarez-Lorenzo, C., Yanez, F., Barreiro-Iglesias, R., and Concheiro, A. Imprinted soft contact lenses as norfloxacin delivery systems. J. Control. Release. 113:236-244, 2006.
50. Tieppo, A., Pate, K.M., & Byrne, M.E. In vitro controlled release of an anti-inflammatory from daily disposable therapeutic contact lenses under physiological ocular tear flow. Eur. J. Pharm. Biopharm. 81:170-177, 2012.
51. Venkatesh, S., Saha, J., Pass, S., & Byrne, M.E. Transport and structural analysis of molecular imprinted hydrogels for controlled drug delivery. Eur. J. Pharm. Biopharm. 69:852-860, 2008.
52. Venkatesh, S., Sizemore, S.P., & Byrne, M.E. Biomimetic hydrogels for enhanced loading and extended release of ocular therapeutics. Biomaterials. 28:717-724, 2007.
53. Ali, M., Horikawa, S., Venkatesh, S., Saha, J., Hong, J.W., and Byrne, M.E. Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow. J. Control. Release. 124:154-162, 2007.
54. Braga, M.E., Costa, V.P., Pereira, M.J., Fiadeiro, P.T., Gomes, A.P., Duarte, C.M., & de Sousa, H.C. Effects of operational conditions on the supercritical solvent impregnation of acetazolamide in Balafilcon A commercial contact lenses. Int. J. Pharm. 420:231-243, 2011.
55. dos Santos, J.F., Alvarez-Lorenzo, C., Silva, M., Balsa, L., Couceiro, J., Torres-Labandeira, J.J., & Concheiro, A. Soft contact lenses functionalized with pendant cyclodextrins for controlled drug delivery. Biomaterials. 30:1348-1355, 2009.
56. Ciolino, J.B., Hoare, T.R., Iwata, N.G., Behlau, I., Dohlman, C.H., Langer, R., & Kohane, D.S. A drug-eluting contact lens. Invest. Ophthalmol. Vis. Sci. 50:3346-3352, 2009.
57. Ciolino, J.B., Hudson, S.P., Mobbs, A.N., Hoare, T.R., Iwata, N.G., Fink, G.R., & Kohane, D.S. A prototype antifungal contact lens. Invest. Ophthalmol. Vis. Sci. 52:6286-6291, 2011.
58. Ribeiro, A., Veiga, F., Santos, D., Torres-Labandeira, J.J., Concheiro, A., & Alvarez-Lorenzo, C. Bioinspired imprinted PHEMA-hydrogels for ocular delivery of carbonic anhydrase inhibitor drugs. Biomacromolecules. 12:701-709, 2011.
59. Hiratani, H., & Alvarez-Lorenzo, C. Timolol uptake and release by imprinted soft contact lenses made of N,Ndiethylacrylamide and methacrylic acid. J. Control. Release. 83:223-230, 2002.
60. Harvitt, D.M., & Bonanno, J.A. Re-evaluation of the oxygen diffusion model for predicting minimum contact lens Dk/t values needed to avoid corneal anoxia. Optom. Vis. Sci. 76:712-719, 1999.
61. White, C.J., McBride, M.K., Pate, K.M., Tieppo, A., & Byrne, M.E. Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses. Biomaterials. 32:5698-5705, 2011.
62. Markoulli, M., Papas, E., Cole, N., & Holden, B. Corneal erosions in contact lens wear. Cont. Lens Anterior Eye. 35:2-8, 2012.
63. Bourcier, T., Thomas, F., Borderie, V., Chaumeil, C., and Laroche, L. Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases. Br. J. Ophthalmol. 87:834-838, 2003.
64. Fonn, D. Targeting contact lens induced dryness and discomfort: what properties will make lenses more comfortable. Optom. Vis. Sci. 84:279-285, 2007.
65. Lemp, M.A. Contact lenses and allergy. Curr. Opin. Allergy Clin. Immunol. 8:457-460, 2008.
66. Schultz, C., Breaux, J., Schentag, J., & Morck, D. Drug delivery to the posterior segment of the eye through hydrogel contact lenses. Clin. Exp. Optom. 94:212-218, 2011.
67. Schaefer, F., Bruttin, O., Zografos, L., & Guex-Crosier, Y. Bacterial keratitis: a prospective clinical and microbiological study. Br. J. Ophthalmol. 85:842-847, 2001.
68. Bower, K.S., Kowalski, R.P., & Gordon, Y.J. Fluoroquinolones in the treatment of bacterial keratitis. Am. J. Ophthalmol. 121:712-715, 1996.
69. Stevens, S.X., Fouraker, B.D., & Jensen, H.G. Intraocular safety of ciprofloxacin. Arch. Ophthalmol. 109:1737-1743, 1991.
70. Hui, A., Boone, A., & Jones, L. Uptake and release of ciprofloxacin-HCl from conventional and silicone hydrogel contact lens materials. Eye Contact Lens. 34:266-271, 2008.
71. Karlgard, C.C., Jones, L.W., & Moresoli, C. Ciprofloxacin interaction with silicon-based and conventional hydrogel contact lenses. Eye Contact Lens. 29:83-89, 2003.
72. Garhwal, R., Shady, S.F., Ellis, E.J., Ellis, J.Y., Leahy, C.D., McCarthy, S.P., Crawford, K.S., & Gaines, P. Sustained ocular delivery of ciprofloxacin using nanospheres and conventional contact lens materials. Invest. Ophthalmol. Vis. Sci. 53:1341-1352, 2012.
73. Kim, M.J., Jun, R.M., Kim, W.K., Hann, H.J., Chong, Y.H., Park, H.Y., & Chung, J.H. Optimal concentration of human epidermal growth factor (hEGF) for epithelial healing in experimental corneal alkali wounds. Curr. Eye Res. 22:272-279, 2001.
74. Schultz, C.L., & Morck, D.W. Contact lenses as a drug delivery device for epidermal growth factor in the treatment of ocular wounds. Clin. Exp. Optom. 93:61-65, 2010.
75. Holland, S., Morck, D., & Schultz, C. Treatment of corneal defects with delayed re-epithelization with a medical device/ drug delivery system for EGF. Clin. Exp. Ophthalmol. 40:662-668, 2012.
76. Bielory, L., & Friedlaender, M.H. Allergic conjunctivitis. Immunol. Allergy Clin. North Am. 28:43-58, vi, 2008.
77. Bielory, L. Role of antihistamines in ocular allergy. Am. J. Med. 113 Suppl 9A:34S-37S, 2002.
78. Gushchin, I.S., & Zebrev, A.I. Ketotifen-induced histamine release, inhibition of histamine secretion and modulation of immune response. Agents Actions. 18:92-95, 1986.
79. Tieppo, A., White, C.J., Paine, A.C., Voyles, M.L., McBride, M.K., & Byrne, M.E. Sustained in vivo release from imprinted therapeutic contact lenses. J. Control. Release. 157: 391-397, 2012.
80. Wolffsohn, J.S., & Emberlin, J.C. Role of contact lenses in relieving ocular allergy. Cont. Lens Anterior Eye. 34:169-172, 2011.
81. Research in dry eye: report of the Research Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 5:179-193, 2007.
82. McCann, L.C., Tomlinson, A., Pearce, E.I., & Papa, V. Effectiveness of artificial tears in the management of evaporative dry eye. Cornea. 31:1-5, 2012.
83. Vogel, R., Crockett, R.S., Oden, N., Laliberte, T.W., and Molina, L. Demonstration of efficacy in the treatment of dry eye disease with 0.18% sodium hyaluronate ophthalmic solution (vismed, rejena). Am. J. Ophthalmol. 149:594-601, 2010.
84. Scheuer, C.A., Fridman, K.M., Barniak, V.L., Burke, S.E., and Venkatesh, S. Retention of conditioning agent hyaluronan on hydrogel contact lenses. Contact Lens Anterior Eye. 33 Suppl 1:S2-S6, 2010.
85. Ali, M., & Byrne, M.E. Controlled release of high molecular weight hyaluronic Acid from molecularly imprinted hydrogel contact lenses. Pharm. Res. 26:714-726, 2009.
86. Gomes, J.A., Amankwah, R., Powell-Richards, A., & Dua, H.S. Sodium hyaluronate (hyaluronic acid) promotes migration of human corneal epithelial cells in vitro. Br. J. Ophthalmol. 88:821-825, 2004.
87. Pitt, W.G., Jack, D.R., Zhao, Y., Nelson, J.L., & Pruitt, J.D. Loading and release of a phospholipid from contact lenses. Optom. Vis. Sci. 88:502-506, 2011.
88. Bhavsar, A.S., Bhavsar, S.G., & Jain, S.M. A review on recent advances in dry eye: Pathogenesis and management. Oman J. Ophthalmol. 4:50-56, 2011.
89. Lemp, M.A. Management of dry eye disease. Am. J. Manage. Care. 14:S88-S101, 2008.
90. Stevenson, D., Tauber, J., & Reis, B.L. Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial. The Cyclosporin A Phase 2 Study Group. Ophthalmology. 107:967-974, 2000.
91. Peng, C.C., & Chauhan, A. Extended cyclosporine delivery by silicone-hydrogel contact lenses. J. Control. Release. 154:267-274, 2011.
92. Schlamp, C.L., Li, Y., Dietz, J.A., Janssen, K.T., & Nickells, R.W. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci. 7:66, 2006.
93. Crooke, A., Colligris, B., & Pintor, J. Update in glaucoma medicinal chemistry: emerging evidence for the importance of melatonin analogues. Curr. Med. Chem. 19:3508-3522, 2012.
94. Carta, F., Supuran, C.T., & Scozzafava, A. Novel therapies for glaucoma: a patent review 2007-2011. Expert Opin. Ther. Pat. 22:79-88, 2012.
95. Hiratani, H., Fujiwara, A., Tamiya, Y., Mizutani, Y., and Alvarez-Lorenzo, C. Ocular release of timolol from molecularly imprinted soft contact lenses. Biomaterials. 26:1293-1298, 2005.
96. Peng, C.C., Ben-Shlomo, A., Mackay, E.O., Plummer, C.E., and Chauhan, A. Drug delivery by contact lens in spontaneously glaucomatous dogs. Curr. Eye Res. 37:204-211, 2012.
97. Schultz, C.L., Poling, T.R., & Mint, J.O. A medical device/ drug delivery system for treatment of glaucoma. Clin. Exp. Optom. 92:343-348, 2009.