Azulene incorporation and release by hydrogel containing methacrylamide propyltrimenthylammonium chloride, and its application to soft contact lens

Journal of Controlled Release

Volumn 92, Issue 3, 2003, Pages 259-264

  Uchida, Rei ^a   Sato, Takao ^a   Tanigawa, Haruyasu ^a   Uno, Kenji ^a  

^a SEED Co Ltd   (Japan)

Author keywords

Azulene; Drug delivery system; Hydrogel; Ion exchange reaction; Soft contact lens

Indexed keywords

CONTACT LENSES; HYDROGELS; ION EXCHANGE; MONOMERS; NEGATIVE IONS; PHYSIOLOGY;

ANIONIC DRUGS;

CONTROLLED DRUG DELIVERY;

2 HYDROXYETHYL METHACRYLATE; 2 METHACRYLOXYETHYL ACID PHOSPHATE; AMMONIUM DERIVATIVE; ANION; AZULENE; CATION; FUNCTIONAL GROUP; METHACRYLAMIDE PROPYLTRIMETHYLAMMONIUM CHLORIDE; METHACRYLIC ACID; METHACRYLIC ACID DERIVATIVE; MONOMER; SODIUM 1,4 DIMETHYL 7 ISOPROPYLAZULENE 3 SULFONATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG STORAGE; HYDROGEL; ION EXCHANGE; PRIORITY JOURNAL; SOFT CONTACT LENS;

AMMONIUM CHLORIDE; AZULENES; BIOCOMPATIBLE MATERIALS; CONTACT LENSES, HYDROPHILIC; CYCLOHEPTANES; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HYDROGELS; ION EXCHANGE; METHACRYLATES; MOLECULAR STRUCTURE; NITRILES; WATER;

EID: 1642393453     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00368-7     Document Type: Article

References (12)

1. Wichterle O., Lim D. Hydrophilic gels for biological use. Nature. 185:1960;117-118.
2. Florkey L., Fink B.A., Mitchell L., Hill R.M. Tear exchange and oxygen reservoir effects in silicone hydrogel systems. Eye & Contact Lens: Science and Clinical Practice. 29(1):2003;90-92.
3. Aquavella J.V., Rao G.N. Contact Lenses. 1987;47-225 J.B. Lippincott, Philadelphia.
4. Ueda K. Using contact lenses among high-school Students in yamaguchi prefecture. J. Jpn. C. L. Soc. 42. 4:2000;178-181.
5. Patrick M., Mitra A.K. Overview of ocular drug delivery and iatrogenic ocular cytophathologies. Mitra A.K. Ophthalmic Drug Delivery Systems. 1993;1-13 Marcel Dekker, New York.
6. Waltman S.R., Kaufman H.E. Use of hydrophilic contact lenses to increase ocular penetration of topical drugs. Invest. Ophthalmol. 9:1970;250-255.
7. Jain M.R. Drug delivery through soft contact lenses. Br. J. Ophthalmol. 72:1988;150-154.
8. Hiratani H., Alvarez-Lorenzo C. Timorol uptake and release by imprinted soft contact lenses made of N, N-diethylacrylamide and methacrylic acid. J. Control. Release. 83:2002;223-230.
9. Sato T., Uchida R., Tanigawa H., Uno K. Jpn. J. Polym. Sci. Technol. 60:2003;235-237.
10. Montero J., Sparholt J., Tanigawa R. Retrospective case series of therapeutic applications of a lotrafilcon a silicone hydrogel soft contact lens. Eye & Contact Lens: Science and Clinical Practice. 29(1):2003;54-56.
11. Dohlman C.H., Dudenhoefer E.J., Khan B.F., Morneault S. Protection of the ocular surface after keratoprosthesis surgery: the role of soft contact lenses. CLAO J. (28):2002;72-74.
12. Uhrich K.E., Cannizzaro S.M., Langer R.S., Shakesheff K.M. Polymeric systems for controlled drug release. Chem. Rev. 99:1999;3181-3198.