Dexamethasone transport and ocular delivery from poly(hydroxyethyl methacrylate) gels

International Journal of Pharmaceutics

Volumn 353, Issue 1-2, 2008, Pages 205-222

  Kim, Jinah ^a   Chauhan, Anuj ^a  

^a University of Florida   (United States)

Author keywords

Charged drugs; Contact lenses; Crosslinking; Dexamethasone; Dexamethasone acetate; Dexamethasone phosphate; Diffusivity; HEMA; Model; Salt effect

Indexed keywords

DEXAMETHASONE; DEXAMETHASONE ACETATE; DEXAMETHASONE SODIUM PHOSPHATE; EYE DROPS; POLYMACON;

AQUEOUS SOLUTION; ARTICLE; BULK DIFFUSION; CONTACT LENS; CORNEA; DIFFUSION; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG MIXTURE; GEL; HUMAN; INTERMETHOD COMPARISON; IONIC STRENGTH; MATHEMATICAL COMPUTING; PARTITION COEFFICIENT; POLYMERIZATION; PREDICTION; PRIORITY JOURNAL; STEROID THERAPY;

BIOLOGICAL TRANSPORT; CORNEA; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; GELS; HUMANS; MODELS, THEORETICAL; OSMOLAR CONCENTRATION; POLYHYDROXYETHYL METHACRYLATE; SOLUBILITY;

EID: 40149110913     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.11.049     Document Type: Article

References (34)

1. Ahmed I., and Patton T.F. Importance of the noncorneal absorption route in topical ophthalmic drug delivery. Invest. Ophthalmol. Vis. Sci. 26 (1985) 584-587
2. Ahmed I., and Patton T.F. Disposition of timolol and inulin in the rabbit eye following corneal versus non-corneal absorption. Int. J. Pharm. 38 (1987) 9-21
3. Arthur B.W., Hay G.J., Wasan S.M., and Willis W.E. Ultrastructural effects of topical timolol on the rabbit cornea-outcome alone and in conjunction with a gas permeable contact-lens. Arch. Ophthalmol. 101 (1983) 1607-1610
4. Banga A.J. Electrically Assisted Transdermal and Topical Drug Delivery (1998), Taylor & Francis, Bristol
5. Canal T., and Peppas N.A. Correlation between mesh size and equilibrium degree of swelling of polymeric networks. J. Biomed. Mater. Res. 23 (1989) 1183-1193
6. Civiale C., Bucaria F., Piazza S., Peri O., Miano F., and Enea V. Ocular permeability screening of dexamethasone esters through combined cellular and tissue systems. J. Ocul. Pharmacol. Ther. 20 (2004) 75-84
7. Clark A.F., and Yorio T. Ophthalmic drug discovery. Nat. Rev. Drug Discov. 2 (2003) 448-459
8. Colombo P., Bettini R., and Peppas N.A. Observation of swelling process and diffusion front position during swelling in hydroxypropyl methyl cellulose (hpmc) matrices containing a soluble drug. J. Controlled Release 61 (1999) 83-91
9. Creech J.L., Chauhan A., and Radke C.J. Dispersive mixing in the posterior tear film under a soft contact lens. Ind. Eng. Chem. Res. 40 (2001) 3015-3026
10. Einmahl S., Zignani M., Varesio E., Heller J., Veuthey J.L., Tabatabay C., and Gurny R. Concomitant and controlled release of dexamethasone and 5-fluorouracil from poly(ortho ester). Int. J. Pharm. 185 (1999) 189-198
11. Ende M.T.A., and Peppas N.A. Transport of ionizable drugs and proteins in crosslinked poly(acrylic acid) and poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogels .2. Diffusion and release studies. J. Controlled Release 48 (1997) 47-56
12. Flynn G.L., and Lamb D.J. Factors influencing solvolysis of corticosteroid-21-phosphate esters. J. Pharm. Sci. 59 (1970) 1433-1438
13. Fristrom B. A 6-month, randomized, double-masked comparison of latanoprost with timolol in patients with open angle glaucoma or ocular hypertension. Acta Ophthalmol. Scan. 74 (1996) 140-144
14. Hillman J.S. Management of acute glaucoma with pilocarpine-soaked hydrophilic lens. Br. J. Ophthalmol. 58 (1974) 674-679
15. Hiratani H., and Alvarez-Lorenzo C. The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems. Biomaterials 25 (2004) 1105-1113
16. Hiratani H., Fujiwara A., Tamiya Y., Mizutani Y., and Alvarez-Lorenzo C. Ocular release of timolol from molecularly imprinted soft contact lenses. Biomaterials 26 (2005) 1293-1298
17. Li C.C., and Chauhan A. Modeling ophthalmic drug delivery by soaked contact lenses. Ind. Eng. Chem. Res. 45 (2006) 3718-3734
18. Mcnamara N.A., Polse K.A., Brand R.J., Graham A.D., Chan J.S., and Mckenney C.D. Tear mixing under a soft contact lens: effects of lens diameter. Am. J. Ophthalmol. 127 (1999) 659-665
19. Melby J.C. Drug spotlight program: Systemic corticosteroid therapy: Pharmacology and endocrinologic considerations. Ann. Intern. Med. 81 (1974) 505-512
20. Ogura Y. Drug delivery to the posterior segments of the eye. Adv. Drug Deliv. Rev 52 (2001) 1-3
21. Ramer R.M., and Gasset A.R. Ocular penetration of pilocarpine: The effect of hydrophilic soft contact lenses on the ocular penetration of pilocarpine. Ann. Ophthalmol. 6 (1974) 1325-1327
22. Rosenwald, P.L., 1984. Occular device. US Patent 4,484,922 (27 November).
23. Ruben M., and Watkins R. Pilocarpine dispensation for the soft hydrophilic contact lens. Br. J. Ophthalmol. 59 (1975) 455-458
24. Schultz, C.L., Nunez, I.M., Silor, D.L., Neil, M.L., 1998. Contact lens containing a leachable absorbed material. US Patent 5,723,131 (03 March).
25. Schultz, C.L., Mint, J.M., 2002. Drug delivery system for antiglaucomatous medication. US Patent 6,410,045 (25 June).
26. Schwartz B. The response of ocular pressure to corticosteroids. Int. Ophthalmol. Clin. 6 (1966) 929-989
27. Urban R.C., and Cotlier E. Corticosteroid-induced cataracts. Surv. Ophthalmol. 31 (1986) 102-110
28. Ward J.H., and Peppas N.A. Preparation of controlled release systems by free-radical UV polymerizations in the presence of a drug. J. Controlled Release 71 (2001) 183-192
29. Weijtens O., Vandersluijs F.A., Schoemaker R.C., Lentjes E.G.W.M., Cohen A.F., Romijn F.P.H.T.M., and Vanmeurs J.C. Peribulbar corticosteroid injection: vitreal and serum concentrations after dexamethasone disodium phosphate injection. Am. J. Ophthalmol. 123 (1997) 358-363
30. Weijtens O., Schoemaker R.C., Cohen A.F., Romijn F.P.H.T.M., Lentjes E.G.W.M., Van Rooij J., and Van Meurs J.C. Dexamethasone concentration in vitreous and serum after oral administration. Am. J. Ophthalmol. 125 (1998) 673-679
31. Weijtens O., Feron E.J., Schoemaker R.C., Cohen A.F., Lentjes E.G.W.M., Romijn F.P.H.T.M., and Van Meurs J.C. High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection. Am. J. Ophthalmol. 128 (1999) 192-197
32. Weijtens O., Schoemaker R.C., Lentjes E.G.W.M., Romijn F.P.H.T.M., Cohen A.F., and Van Meurs J.C. Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose. Ophthalmology 107 (2000) 1932-1938
33. Weijtens O., Schoemaker R.C., Romijn F.P.H.T.M., Cohen A.F., Lentjes E.G.W.M., and Van Meurs J.C. Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate. Ophthalmology 109 (2002) 1887-1891
34. Wilson M.C., and Shields M.B. A comparison of the clinical variations of the iridocorneal endothelial syndrome. Arch. Ophthalmol. 107 (1989) 1465-1468