Chronic multiple sclerosis lesions: Characterization with high-field-strength MR imaging

Radiology

Volumn 262, Issue 1, 2012, Pages 206-215

  Yao, Bing ^a   Bagnato, Francesca ^b   Matsuura, Eiji ^a   Merkle, Hellmut ^a   Van Gelderen, Peter ^a   Cantor, Fredric K ^a   Duyn, Jeff H ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON; MYELIN;

ADULT; AGED; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; INFORMED CONSENT; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; QUANTITATIVE ANALYSIS; RADIATION ATTENUATION; SUSCEPTIBILITY WEIGHTED IMAGING;

ADULT; BRAIN; CADAVER; CHRONIC DISEASE; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RETROSPECTIVE STUDIES; STAINING AND LABELING;

EID: 84455206532     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.11110601     Document Type: Article

References (40)

1. Gilmore CP, DeLuca GC, Bö L, et al. Spinal cord neuronal pathology in multiple sclerosis. Brain Pathol 2009;19(4):642-649.
2. Bagnato F, Yao B, Cantor F, et al. Multisequence-imaging protocols to detect cortical lesions of patients with multiple sclerosis: observations from a post-mortem 3 Tesla imaging study. J Neurol Sci 2009;282(1-2):80-85.
3. Goldberg-Zimring D, Mewes AU, Maddah M, Warfield SK. Diffusion tensor magnetic resonance imaging in multiple sclerosis. J Neuroimaging 2005;15(4, Suppl):68S-81S. (Pubitemid 43010533)
4. Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM. White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis. J Neurol 2002;249(9):1279-1286. (Pubitemid 35025108)
5. Bakshi R, Benedict RH, Bermel RA, et al. T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study. Arch Neurol 2002;59(1):62-68. (Pubitemid 34052557)
6. Laule C, Vavasour IM, Moore GR, et al. Water content and myelin water fraction in multiple sclerosis: a T2 relaxation study. J Neurol 2004;251(3):284-293. (Pubitemid 38387145)
7. Karampekios S, Papanikolaou N, Papadaki E, et al. Quantification of magnetization transfer rate and native T1 relaxation time of the brain: correlation with magnetization transfer ratio measurements in patients with multiple sclerosis. Neuroradiology 2005;47(3):189-196. (Pubitemid 40778824)
8. Chen JT, Kuhlmann T, Jansen GH, et al. Voxel-based analysis of the evolution of magnetization transfer ratio to quantify remyelination and demyelination with histopathological validation in a multiple sclerosis lesion. Neuroimage 2007;36(4):1152-1158. (Pubitemid 47001724)
9. Hammond KE, Metcalf M, Carvajal L, et al. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol 2008;64(6):707-713.
10. Haacke EM, Makki M, Ge Y, et al. Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging 2009;29(3):537-544.
11. Duyn JH, van Gelderen P, Li TQ, de Zwart JA, Koretsky AP, Fukunaga M. High-field MRI of brain cortical substructure based on signal phase. Proc Natl Acad Sci U S A 2007;104(28):11796-11801. (Pubitemid 47175092)
12. Li TQ, Yao B, van Gelderen P, et al. Characterization of T(2)* heterogeneity in human brain white matter. Magn Reson Med 2009;62(6):1652-1657.
13. Haacke EM, Cheng NY, House MJ, et al. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 2005;23(1):1-25. (Pubitemid 40269946)
14. Ogg RJ, Langston JW, Haacke EM, Steen RG, Taylor JS. The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 1999;17(8):1141-1148. (Pubitemid 29444639)
15. Sedlacik J, Helm K, Rauscher A, Stadler J, Mentzel HJ, Reichenbach JR. Investigations on the effect of caffeine on cerebral venous vessel contrast by using susceptibility-weighted imaging (SWI) at 1.5, 3 and 7 T. Neuroimage 2008;40(1):11-18.
16. Zhong K, Leupold J, von Elverfeldt D, Speck O. The molecular basis for gray and white matter contrast in phase imaging. Neuroimage 2008;40(4):1561- 1566.
17. He X, Yablonskiy DA. Biophysical mechanisms of phase contrast in gradient echo MRI. Proc Natl Acad Sci U S A 2009;106(32):13558-13563.
18. Schäfer A, Wharton S, Gowland P, Bowtell R. Using magnetic field simulation to study susceptibility-related phase contrast in gradient echo MRI. Neuroimage 2009;48(1):126-137.
19. Lee J, Hirano Y, Fukunaga M, Silva AC, Duyn JH. On the contribution of deoxyhemoglobin to MRI gray-white matter phase contrast at high field. Neuroimage 2010;49(1):193-198.
20. Yao B, Li TQ, Gelderen P, Shmueli K, de Zwart JA, Duyn JH. Susceptibility contrast in high field MRI of human brain as a function of tissue iron content. Neuroimage 2009;44(4):1259-1266.
21. Craelius W, Migdal MW, Luessenhop CP, Sugar A, Mihalakis I. Iron deposits surrounding multiple sclerosis plaques. Arch Pathol Lab Med 1982;106(8):397-399.
22. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 2005;58(6):840-846. (Pubitemid 41746873)
23. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33(11):1444-1452. (Pubitemid 14237132)
24. van Gelderen P, de Zwart JA, Starewicz P, Hinks RS, Duyn JH. Real-time shimming to compensate for respiration-induced B0 fluctuations. Magn Reson Med 2007;57(2):362-368. (Pubitemid 46214539)
25. de Zwart JA, Ledden PJ, van Gelderen P, Bodurka J, Chu R, Duyn JH. Signal-to-noise ratio and parallel imaging performance of a 16-channel receive-only brain coil array at 3.0 Tesla. Magn Reson Med 2004;51(1):22-26. (Pubitemid 38095698)
26. Filippi M, Gawne-Cain ML, Gasperini C, et al. Effect of training and different measurement strategies on the reproducibility of brain MRI lesion load measurements in multiple sclerosis. Neurology 1998;50(1):238-244. (Pubitemid 28106048)
27. Bagnato F, Jeffries N, Richert ND, et al. Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years. Brain 2003;126(Pt 8):1782-1789. (Pubitemid 36917337)
28. Fukunaga M, Li TQ, van Gelderen P, et al. Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A 2010;107(8):3834-3839.
29. Schenck JF, Zimmerman EA, Li Z, et al. High-field magnetic resonance imaging of brain iron in Alzheimer disease. Top Magn Reson Imaging 2006;17(1):41-50. (Pubitemid 46672932)
30. Liu C, Li W, Johnson GA, Wu B. High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. Neuroimage 2011;56(3):930-938.
31. Lee J, Yao B, Palumbo S, et al. MRI T2*relaxation and frequency contrast changes in cuprizone-fed mice. 17th Organization for Human Brain Mapping Annual Meeting, Quebec City, Canada, 2011.
32. Dietrich RB, Bradley WG Jr. Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children. Radiology 1988;168(1):203-206.
33. Schenck JF. Imaging of brain iron by magnetic resonance: T2 relaxation at different field strengths. J Neurol Sci 1995;134(Suppl):10-18.
34. Connor JR, Menzies SL, St Martin SM, Mufson EJ. A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res 1992;31(1):75-83.
35. Connor JR, Menzies SL. Relationship of iron to oligodendrocytes and myelination. Glia 1996;17(2):83-93. (Pubitemid 26309437)
36. Levine SM, Chakrabarty A. The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann N Y Acad Sci 2004;1012:252-266. (Pubitemid 38453530)
37. Gellein K, Flaten TP, Erikson KM, Aschner M, Syversen T. Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res 2008;121(3):221-225.
38. Chua-anusorn W, Webb J, Macey DJ, Pootrakul P, St Pierre TG. The effect of histological processing on the form of iron in iron-loaded human tissues. Biochim Biophys Acta 1997;1360(3):255-261. (Pubitemid 27226999)
39. Schrag M, Dickson A, Jiffry A, Kirsch D, Vinters HV, Kirsch W. The effect of formalin fixation on the levels of brain transition metals in archived samples. Biometals 2010;23(6):1123-1127.
40. Schenck JF. Magnetic resonance imaging of brain iron. J Neurol Sci 2003;207(1-2):99-102. (Pubitemid 36287110)