Human intrahepatic biliary epithelial cells engulf blebs from their apoptotic peers

Clinical and Experimental Immunology

Volumn 172, Issue 1, 2013, Pages 95-103

  Rong, G H ^a,c   Yang, G X ^a   Ando, Y ^a   Zhang, W ^a   He, X S ^a   Leung, P S C ^a   Coppel, R L ^e   Ansari, A A ^b   Zhong, R ^d   Gershwin, M E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BEIJING 302 HOSPITAL   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Apoptosis; Chemokine; Intrahepatic biliary epithelial cells; Phagocytosis

Indexed keywords

INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLSERINE; TOLL LIKE RECEPTOR;

ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL DESTRUCTION; CELL FUNCTION; CELL PHAGOCYTOSIS; CONTROLLED STUDY; CYTOLOGY; EPITHELIUM CELL; HUMAN; HUMAN CELL; LIVER CELL; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; APOPTOSIS; BILE ACIDS AND SALTS; BILE DUCTS, INTRAHEPATIC; CELLS, CULTURED; CHEMOKINE CCL2; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; LIVER CIRRHOSIS, BILIARY; MACROPHAGES; MICE; PHAGOCYTOSIS; PHOSPHATIDYLSERINES; POLY I-C; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 84875001882     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12046     Document Type: Article

References (45)

1. Savill J, Fadok V. Corpse clearance defines the meaning of cell death. Nature 2000; 407:784-788.
2. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 2000; 405:85-90.
3. Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA. Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 2003; 302:1560-1563.
4. Reed JC. Dysregulation of apoptosis in cancer. J Clin Oncol 1999; 17:2941-2953.
5. Erwig LP, Henson PM. Clearance of apoptotic cells by phagocytes. Cell Death Differ 2007; 15:243-250.
6. Platt N, da Silva RP, Gordon S. Recognizing death: the phagocytosis of apoptotic cells. Trends Cell Biol 1998; 8:365-372.
7. Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2002; 2:965-975.
8. Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med 2005; 353:1261-1273.
9. Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ. Primary biliary cirrhosis. Hepatology 2009; 50:291-308.
10. Fahey J, Wallace P, Johnson K, Guyre P, Wira C. Antigen presentation by human uterine epithelial cells to autologous T cells. Am J Reprod Immunol 2006; 55:1-11.
11. Gereke M, Jung S, Buer J, Bruder D. Alveolar type II epithelial cells present antigen to CD4+ T cells and induce Foxp3+ regulatory T cells. Am J Respir Crit Care Med 2009; 179:344-355.
12. Monks J, Rosner D, Geske F etal. Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ 2005; 12:107-114.
13. Mulder DJ, Pooni A, Mak N, Hurlbut DJ, Basta S, Justinich CJ. Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis. Am J Pathol 2011; 178:744-753.
14. Parnaik R, Raff M, Scholes J. Differences between the clearance of apoptotic cells by professional and non-professional phagocytes. Curr Biol 2000; 10:857-860.
15. Lleo A, Selmi C, Invernizzi P etal. Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology 2009; 49:871-879.
16. Rong G, Zhong R, Lleo A etal. Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis. Hepatology 2011; 54:196-203.
17. Strain A, Wallace L, Joplin R etal. Characterization of biliary epithelial cells isolated from needle biopsies of human liver in the presence of hepatocyte growth factor. Am J Pathol 1995; 146:537-545.
18. Yang Y, Raper S, Cohn J, Engelhardt J, Wilson J. An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. Proc Natl Acad Sci USA 1993; 90:4601-4605.
19. Lleo A, Bowlus CL, Yang G-X etal. Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 2010; 52:987-998.
20. Esmann L, Idel C, Sarkar A etal. Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells. J Immunol 2010; 184:391-400.
21. Cooper PH, Mayer P, Baggiolini M. Stimulation of phagocytosis in bone marrow-derived mouse macrophages by bacterial lipopolysaccharide: correlation with biochemical and functional parameters. J Immunol 1984; 133:913-922.
22. Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ. Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis. J Pediatr Surg 2007; 42:927-932; discussion 933.
23. Monks J, Rosner D, Geske FJ etal. Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ 2005; 12:107-114.
24. Kolb S, Vranckx R, Huisse MG, Michel JB, Meilhac O. The phosphatidylserine receptor mediates phagocytosis by vascular smooth muscle cells. J Pathol 2007; 212:249-259.
25. Chen M, Forrester JV, Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLOS ONE 2011; 6:e22818.
26. Kim YG, Kamada N, Shaw MH etal. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity 2011; 34:769-780.
27. Dewald O, Zymek P, Winkelmann K etal. CCL2/monocyte chemoattractant protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res 2005; 96:881-889.
28. Daley-Bauer LP, Wynn GM, Mocarski ES. Cytomegalovirus impairs antiviral CD8(+) T cell immunity by recruiting inflammatory monocytes. Immunity 2012; 37:122-133.
29. Das ST, Rajagopalan L, Guerrero-Plata A etal. Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment. PLOS ONE 2010; 5:e11754.
30. Loos T, Opdenakker G, Van Damme J, Proost P. Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation. Haematologica 2009; 94:1346-1353.
31. Lleo A, Selmi C, Invernizzi P, Podda M, Gershwin ME. The consequences of apoptosis in autoimmunity. J Autoimmun 2008; 31:257-262.
32. Rabinovitch M. Professional and non-professional phagocytes: an introduction. Trends Cell Biol 1995; 5:85-87.
33. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980; 68:251-306.
34. Parnaik R, Raff MC, Scholes J. Differences between the clearance of apoptotic cells by professional and non-professional phagocytes. Curr Biol 2000; 10:857-860.
35. Taylor PR, Carugati A, Fadok VA etal. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 2000; 192:359-366.
36. Gregory CD, Devitt A. The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically? Immunology 2004; 113:1-14.
37. Elliott MR, Ravichandran KS. Clearance of apoptotic cells: implications in health and disease. J Cell Biol 2010; 189:1059-1070.
38. Chekeni FB, Ravichandran KS. The role of nucleotides in apoptotic cell clearance: implications for disease pathogenesis. J Mol Med (Berl) 2011; 89:13-22.
39. Peng Y, Martin DA, Kenkel J, Zhang K, Ogden CA, Elkon KB. Innate and adaptive immune response to apoptotic cells. J Autoimmun 2007; 29:303-309.
40. Licht R, Dieker JW, Jacobs CW, Tax WJ, Berden JH. Decreased phagocytosis of apoptotic cells in diseased SLE mice. J Autoimmun 2004; 22:139-145.
41. Mevorach D, Zhou JL, Song X, Elkon KB. Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med 1998; 188:387-392.
42. Naiyanetr P, Butler JD, Meng L etal. Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. J Autoimmun 2011; 37:209-216.
43. Selmi C, Meroni PL, Gershwin ME. Primary biliary cirrhosis and Sjogren's syndrome: autoimmune epithelitis. J Autoimmun 2012; 39:34-42.
44. You Z, Wang Q, Bian Z etal. The immunopathology of liver granulomas in primary biliary cirrhosis. J Autoimmun 2012; 39:216-221.
45. Allina J, Hu B, Sullivan DM etal. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun 2006; 27:232-241.