In vivo imaging of hemodynamics and oxygen metabolism in acute focal cerebral ischemic rats with laser speckle imaging and functional photoacoustic microscopy

Journal of Biomedical Optics

Volumn 17, Issue 8, 2012, Pages

  Deng, Zilin ^a,b   Wang, Zhen ^a,b   Yang, Xiaoquan ^a,b   Luo, Qingming ^a,b   Gong, Hui ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Ischemia; Laser speckle imaging; Photoacoustic microscopy

Indexed keywords

DIAGNOSTIC AGENT; OXYGEN;

ACOUSTIC MICROSCOPY; ANIMAL; ARTICLE; BLOOD FLOW VELOCITY; BRAIN; BRAIN CIRCULATION; BRAIN ISCHEMIA; ECHOENCEPHALOGRAPHY; ECHOGRAPHY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; INSTRUMENTATION; LASER; MALE; METABOLISM; OXIMETRY; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOACOUSTICS; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD FLOW VELOCITY; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; ECHOENCEPHALOGRAPHY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; LASERS; MALE; MICROSCOPY, ACOUSTIC; OXIMETRY; OXYGEN; PHOTOACOUSTIC TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84874999168     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.8.081415     Document Type: Article

References (59)

1. A. Durukan and T. Tatlisumak, "Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia," Pharmacol. Biochem. Behav. 87(1), 179-197 (2007). (Pubitemid 46860315)
2. U. Dirnagl, C. Iadecola, and M. A. Moskowitz, "Pathobiology of ischaemic stroke: an integrated view," Trends. Neurosci. 22(9), 391-397 (1999). (Pubitemid 29453643)
3. R. R. Moustafa and J. C. Baron, "Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery," Br. J. Pharmacol. 153(S1), S44-S54 (2008). (Pubitemid 351340992)
4. K. W. Muir et al., "Imaging of acute stroke," Lancet. Neurol. 5(9), 755-768 (2006). (Pubitemid 44205513)
5. S. Hu and L. V. Wang, "Photoacoustic imaging and characterization of the microvasculature," J. Biomed. Opt. 15(1), 011101 (2010).
6. J. K.-J. Li, Dynamics of the Vascular System, World Scientific, Singapore (2004).
7. A. K. Dunn et al., "Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation," Opt. Lett. 28(1), 28-30 (2003).
8. J. P. Culver et al., "Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia," J. Cereb. Blood. Flow. Metab. 23(8), 911-924 (2003). (Pubitemid 36959397)
9. D. S. Liebeskind, "Imaging the future of stroke: I. ischemia," Ann. Neurol. 66(5), 574-590 (2009).
10. D. D. McLeod et al., "Establishing a rodent stroke perfusion computed tomography model," Int. J. Stroke 6(4), 284-289 (2011).
11. Q. Shen et al., "Functional, perfusion and diffusion MRI of acute focal ischemic brain injury," J. Cereb. Blood. Flow. Metab. 25(10), 1265-1279 (2005). (Pubitemid 41348729)
12. M. Ibaraki et al., "PET measurements of CBF, OEF, and CMRO2 without arterial sampling in hyperacute ischemic stroke: method and error analysis," Ann. Nucl. Med. 18(1), 35-44 (2004). (Pubitemid 38478407)
13. L. F. Yu et al., "Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model," J. Biomed. Opt. 15(6), 066006 (2010).
14. C. M. Niell and S. J. Smith, "Live optical imaging of nervous system development," Ann. Rev. Physiol. 66, 771-798 (2004). (Pubitemid 40614462)
15. N. Pouratian et al., "Shedding light on brain mapping: advances in human optical imaging," Trends. Neurosci. 26(5), 277-282 (2003). (Pubitemid 36556159)
16. V. Ntziachristos, "Going deeper than microscopy: the optical imaging frontier in biology," Nat. Methods 7(8), 603-614 (2010).
17. T. Wolf et al., "Noninvasive near infrared spectroscopy monitoring of regional cerebral blood oxygenation changes during peri-infarct depolarizations in focal cerebral ischemia in the rat," J. Cereb. Blood. Flow. Metab. 17(9), 950-954 (1997). (Pubitemid 27396583)
18. J. Luckl et al., "The biological effect of contralateral forepaw stimulation in rat focal cerebral ischemia: a multispectral optical imaging study," Front. Neuroenergetics 2(19), 1-9 (2010).
19. P. B. Jones et al., "Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia," J. Biomed. Opt. 13(4), 044007 (2008).
20. D. Abookasis et al., "Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination," J. Biomed. Opt. 14(2), 024033 (2009).
21. H. K. Shin et al., "Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia," Brain 130(6), 1631-1642 (2007). (Pubitemid 47355921)
22. S. Hu and L. V. Wang, "Neurovascular photoacoustic tomography," Front. Neuroenergetics 2(10), 1-7 (2010).
23. P. G. Haydon and G. Carmignoto, "Astrocyte control of synaptic transmission and neurovascular coupling," Physiol. Rev. 86(3), 1009-1031 (2006). (Pubitemid 44033387)
24. J. Qiu et al., "Spatiotemporal laser speckle contrast analysis for blood flow imaging with maximized speckle contrast," J. Biomed. Opt. 15(1), 016003 (2010).
25. S. Liu, P. Li, and Q. Luo, "Fast blood flow visualization of highresolution laser speckle imaging data using graphics processing unit," Opt. Express 16(19), 14321-14329 (2008).
26. C. Ayata et al., "Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex," J. Cereb. Blood. Flow. Metab. 24(7), 744-755 (2004). (Pubitemid 38880219)
27. Q. Guo, G. Wang, and S. Namura, "Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice," J. Cereb. Blood. Flow. Metab. 30(1), 70-78 (2010).
28. H. Bolay et al., "Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model," Nat. Med. 8(2), 136-142 (2002). (Pubitemid 34155124)
29. A. K. Dunn et al., "Dynamic imaging of cerebral blood flow using laser speckle," J. Cereb. Blood. Flow. Metab. 21(3), 195-201 (2001). (Pubitemid 32207418)
30. B. Choi, N. M. Kang, and J. S. Nelson, "Laser speckle imaging for monitoring blood flow dynamics in the in vivo rodent dorsal skin fold model," Microvasc. Res. 68(2), 143-146 (2004). (Pubitemid 39093888)
31. M. H. Xu and L. H. V. Wang, "Photoacoustic imaging in biomedicine," Rev. Sci. Instrum. 77(4), 041101 (2006).
32. L. V. Wang, "Prospects of photoacoustic tomography," Med. Phys. 35(12), 5758-5767 (2008).
33. L. V. Wang, "Multiscale photoacoustic microscopy and computed tomography," Nat. Photonics 3, 503-509 (2009).
34. X. D. Wang et al., "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21(7), 803-806 (2003).
35. E.W. Stein, K. Maslov, and L. H. V. Wang, "Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy," J. Biomed. Opt. 14(2), 020502 (2009).
36. K. Maslov, G. Stoica, and L. H. V. Wang, "In vivo dark-field reflectionmode photoacoustic microscopy," Opt. Lett. 30(6), 625-627 (2005). (Pubitemid 40402333)
37. H. F. Zhang et al., "Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy," Appl. Phys. Lett. 90(5) 053901 (2007).
38. V. Tsytsarev et al., "Photoacoustic microscopy of microvascular responses to cortical electrical stimulation," J. Biomed. Opt. 16(7), 076002 (2011).
39. J. J. Yao et al., "Label-free oxygen-metabolic photoacoustic microscopy in vivo," J. Biomed. Opt. 16(7), 076003 (2011).
40. H. F. Zhang et al., "Functional photoacoustic microscopy for highresolution and noninvasive in vivo imaging," Nat. Biotechnol. 24(7), 848-851 (2006). (Pubitemid 44086627)
41. Z. Wang et al., "Acute hyperglycemia compromises cerebral blood flow following cortical spreading depression in rats monitored by laser speckle imaging," J. Biomed. Opt. 13(6), 064023 (2008).
42. X. Q. Yang et al., "High-resolution photoacoustic microscope for rat brain imaging in vivo," Chin. Opt. Lett. 8(6), 609-611 (2010).
43. Z. L. Deng et al., "Two-dimensional synthetic-aperture focusing technique in photoacoustic microscopy," J. Appl. Phys. 109(10), 104701 (2011).
44. S. Hu et al., "Optical-resolution photoacoustic microscopy of ischemic stroke," Proc. SPIE 7899, 789906 (2011).
45. R. Khatri et al., "Leptomeningeal collateral response and extent of ischemic penumbra in patients with acute middle cerebral artery occlusion," Neurology 72(11), A156-A156 (2009).
46. B. K. Menon et al., "Does presence of vascular risk factors and elapsed time from stroke onset affect leptomeningeal collateral (LMC) recruitment in acute ischemic stroke?," Stroke 41(7), E483-E483 (2010).
47. S. T. Carmichael, "Rodent models of focal stroke: size, mechanism, and purpose," NeuroRx 2(3), 396-409 (2005). (Pubitemid 41444874)
48. H. K. Shin et al., "Vasoconstrictive neurovascular coupling during focal ischemic depolarizations," J. Cereb. Blood. Flow. Metab. 26(8), 1018-1030 (2006). (Pubitemid 44134074)
49. X. L. Sun et al., "Simultaneous monitoring of intracellular pH changes and hemodynamic response during cortical spreading depression by fluorescence-corrected multimodal optical imaging," Neuroimage 57(3), 873-884 (2011).
50. E. Farkas, F. Bari, and T. P. Obrenovitch, "Multi-modal imaging of anoxic depolarization and hemodynamic changes induced by cardiac arrest in the rat cerebral cortex," Neuroimage 51(2), 734-742 (2010).
51. F. Caramia et al., "Mismatch between cerebral blood volume and flow index during transient focal ischemia studied with MRI and Gd-BOPTA," Magn. Reson. Imaging. 16(2), 97-103 (1998). (Pubitemid 28096178)
52. C. P. Derdeyn et al., "Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited," Brain 125, 595-607 (2002). (Pubitemid 34194414)
53. B. R. Thanvi, S. Treadwell, and T. Robinson, "Haemorrhagic transformation in acute ischaemic stroke following thrombolysis therapy: classification, pathogenesis and risk factors," Postgrad. Med. J. 84(993), 361-367 (2008).
54. G. F. Hamann, Y. Okada, and G. J. del Zoppo, "Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion," J. Cereb. Blood. Flow. Metab. 16(6), 1373-1378 (1996). (Pubitemid 26365393)
55. G. J. del Zoppo, R. Von Kummer, and G. F. Hamann, "Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke," J. Neurol. Neurosurg. Psychiatry. 65(1), 1-9 (1998). (Pubitemid 28302350)
56. J. Luckl et al., "Characterization of periinfarct flow transients with laser speckle and Doppler after middle cerebral artery occlusion in the rat," J. Neurosci. Res. 87(5), 1219-1229 (2009).
57. G. Zaharchuk et al., "Is all perfusion-weighted magnetic resonance imaging for stroke equal? The temporal evolution of multiple hemodynamic parameters after focal ischemia in rats correlated with evidence of infarction," J. Cereb. Blood. Flow. Metab. 20(9), 1341-1351 (2000).
58. C. Tsuchida et al., "Evaluation of peri-infarcted hypoperfusion with T2*-weighted dynamic MRI," Jmri-J. Magn. Reson. Im. 7(3), 518-522 (1997). (Pubitemid 28360869)
59. W. D. Heiss et al., "Repeat positron emission tomographic studies in transient middle cerebral artery occlusion in cats: residual perfusion and efficacy of postischemic reperfusion," J. Cereb. Blood. Flow. Metab. 17(4), 388-400 (1997).