Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 8, 2003, Pages 911-924

  Culver, Joseph P ^a,b   Durduran, Turgut ^a   Furuya, Daisuke ^a   Cheung, Cecil ^a   Greenberg, Joel H ^a   Yodh, A G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cerebral blood flow; Cerebral metabolic rate of oxygen consumption; Diffuse optical tomography; Ischemia; Laser Doppler flowmetry; Tissue oxygen saturation

Indexed keywords

HEMOGLOBIN; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; DEVICE; DIFFUSE OPTICAL TOMOGRAPHY; HEMODYNAMICS; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN SATURATION; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; STROKE; TOMOGRAPHY;

EID: 0043071485     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000076703.71231.BB     Document Type: Article

References (68)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD (1998) Gender-linked brain injury in experimental stroke. Stroke 29:159-166
2. Ances BM, Wilson DF, Greenberg JH, Detre JA (2001) Dynamic changes in cerebral blood flow, 0-2 tension, and calculated cerebral metabolic rate of O-2 during functional activation using oxygen phosphorescence quenching. J Cereb Blood Flow Metab 21:511-516
3. Barbour RL, Graber HL, Chang J, Barbour SS, Koo PC, Aronson R (1995) MRI-guided optical tomography: prospects and computation for a new imaging method. IEEE Comp Sci Eng 2:63-77
4. Benaron DA, Hintz SR, Villringer A, Boas D, Kleinschmidt A, Frahm J, Hirth C, Obrig H, van Houten JC, Kermit EL, Cheong WF, Stevenson DK (2000) Noninvasive functional imaging of human brain using light. J Cereb Blood Flow Metab 20:469-477
5. Boas DA, Campbell LE, Yodh AG (1995) Scattering and imaging with diffusing temporal field correlations. Phys Rev Lett 75:1855-1858
6. Boas DA, Culver JP, Stott JJ, Dunn A (2002) Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head. Opt Express 10:159-170
7. Boas DA, Gaudette T, Strangman G, Cheng XF, Marota JJA, Mandeville JB (2001) The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics. Neuroimage 13:76-90
8. Boas DA, Yodh AG (1997) Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation. J Opt Soc Am A Opt Image Sci Vis 14:192-215
9. Cheng X, Boas DA (1999) Systematic diffuse optical image errors resulting from uncertainty in the background optical properties. Opt Express 4:299-307
10. Cheung C, Culver JP, Yodh AG, Takahashi K, Greenberg JH (2001) In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies. Phys Med Biol 46:2053-2065
11. Cubeddu R, D'Andrea C, Pifferi A, Taroni P, Torricelli A, Valentini G (2000) Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast. Photochem Photobiol 72:383-391
12. Culver JP, Choe R, Holboke MJ, Zubkov L, Durduran T, Slemp A, Ntziachristos V, Chance B, Yodh AG (2003) Three dimensional diffuse optical tomography in the plane parallel transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging. Med Phys 30:235-247
13. Culver JP, Durduran T, Cheung C, Yodh AG, Takahashi K, Greenberg JH (2002a) Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia, and cardiac arrest. Adv Exp Med Biol 510:48
14. Culver JP, Ntziachristos V, Holboke MJ, Yodh AG (2001) Optimization of optode arrangements for diffuse optical tomography: a singular-value analysis. Opt Lett 26:701-703
15. Culver JP, Siegel AM, Franceschini MA, Marota JJ, Mandeville JB, Boas DA (2002b) A comparison of hemodynamic contrasts for functional imaging with diffuse optical tomography. In: ISMRM 2002, Honolulu, Hawaii: ISMRM, p 650
16. Delpy DT, Cope M, van der Zee P, et al (1988) Estimation of optical pathlength through tissue from direct time of flight measurement. Phys Med Biol 33:1433-1442
17. Detre JA, Alsop DC (1999) Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system. Eur J Radiol 30:115-124
18. Dunn AK, Devor A, Bolay H, et al (2003) Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation. Opt Lett 28:28-30
19. Dunn AK, Bolay H, Moskowitz MA, Boas DA (2001) Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab 21:195-201
20. Fantini S, Hueber D, Franceschini MA, Gratton E, Rosenfeld W, Stubblefield PG, Maulik D, Stankovic MR (1999) Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency -domain spectroscopy. Phys Med Biol 44:1543-1563
21. Firbank M, Arridge SR, Schweiger M, Delpy DT (1996) An investigation of light transport through scattering bodies with nonscattering regions. Phys Med Biol 41:767-783
22. Frackowiak RS, Lenzi GL, Jones T, Heather JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 150 and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 4:727-736
23. Franceschini MA, Boas DA, Zourabian A, Solomon GD, Nadgir S, Lin DW, Moore JB, Fantini S (2002) Near infrared spiroximetry: non-invasive measurements of venous saturation in piglets and human subjects. J Appl Physiol 91:372-384
24. Gesztelyi G, Finnegan W, DeMaro JA, Wang JY, Chen JL (1993) Parenchymal microvascular systems and cerebral atrophy in spontaneously hypertensive rats. Brain Res 611:249-257
25. Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN (1986) Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature 324:361-364
26. Grubb RL, Raichle ME, Eichling JO, Terpogos MM (1974) Effects of changes in Paco2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 5:630-639
27. Hale GM, Querry MR (1973) Optical constants of water in the 200 nm to 200 μm wavelength region. Appl Opt 12:555-563
28. Haskell RC, Svaasand LO, Tsay TT, Feng TC, McAdams MS (1994) Boundary conditions for the diffusion equation in radiative transfer. J Opt Soc Am A Opt Image Sci Vis 11:2727-2741
29. Heiss WD, Graf R, Lottgen J, Ohta K, Fujita T, Wagner R, Grond M, Weinhard K (1997) Repeat positron emission tomographic studies in transient middle cerebral artery occlusion in cats: residual perfusion and efficacy of postischemic reperfusion. J Cereb Blood Flow Metab 17:388-400
30. Heiss WD, Graf R, Wienhard K, Lottgen J, Saito R, Fujita T, Rosner G, Wagner R (1994) Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab 14:892-902
31. Hintz SR, Cheong WF, Van Houten JP, Stevenson DK, Benaron DA (1999) Bedside imaging of intracranial hemorrhage in the neonate using light: comparison with ultrasound, computed tomography, and magnetic resonance imaging. Pediatr Res 45:54-59
32. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB (1999) Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model. Magn Reson Med 42:849-863
33. Hueber DM, Franceschini MA, Ma HY, Zhang Q, Ballesteros JR, Fantini S, Wallace D, Ntziachristos V, Chance B (2001) Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument. Phys Med Biol 46:41-62
34. Hyder F, Shulman RG, Rothman DL (1998) A model for the regulation of cerebral oxygen delivery. J Appl Physiol 85:554-564
35. Intaglietta M, Johnson PC, Winslow RM (1996) Microvascular and tissue oxygen distribution. Cardiovasc Res 32:632-643
36. Jobsis FF (1977) Nonivasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198:1264-1267
37. Kak AC, Slaney M (1988) Principles of computerized tomographic imaging. New York: IEEE Press
38. Kohl M, Lindauer U, Dirnagl U, Villringer A (1998a) Separation of changes in light scattering and chromophore concentrations during cortical spreading depression in rats. Opt Lett 23:555-557
39. Kohl M, Nolte C, Heekeren HR, Horst S, Scholz U, Obrig H, Villringer A (1998b) Determination of the wavelength dependence of the differential pathlength factor from near-infrared pulse signals. Phys Med Biol 43:1771-1782
40. Koizumi J, Nakazawa T, Yoshida Y (1985) Reperfusable brain infarction model in the rat (abstract). In: Proceedings of the 10th Meeting of the Japanese Stroke Society, Kyoto, Japan: Japanese Stroke Society, p 159
41. Kusaka T, Isobe K, Nagano K, Okubo K, Yasuda S, Kondo M, Itoh S, Onishi S (2001) Estimation of regional cerebral blood flow distribution in infants by near-infrared topography using indocyanine green. Neuroimage 13:944-952
42. Lollmar R, Schabitz WR, Heiland S, Georgiadis D, Schellinger PD, Bardutzky J, Schwab S (2002) Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia. An MRI study. Stroke 33:1899-1904
43. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
44. Malonek D, Grinvald A (1996) Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping. Science 272:551-554
45. Mandeville JB, Marota JJA, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR (1999) MRI measurement of the temporal evolution of relative CMRO2 during rat forepaw stimulation. Magn Reson Med 42:944-951
46. Mayhew J, Johnston D, Berwick J, Jones M, Coffey P, Zheng Y (2000) Spectroscopic analysis of neural activity in brain: Increased oxygen consumption following activation of barrel cortex. Neuroimage 12:664-675
47. Mayhew J, Johnston D, Martindale J, Jones M, Berwick J, Zheng Y (2001) Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex. Neuroimage 13:975-987.
48. Mayhew J, Zheng Y, Hou YQ, Vuksanovic B, Berwick J, Askew S, Coffey P (1999) Spectroscopic analysis of changes in remitted illumination: the response to increased neural activity in brain. Neuroimage 10:304-326
49. Narayanan U, Chi OZ, Liu X, Weiss HR (2000) Effect of AMPA on cerebral cortical oxygen balance of ischemic rat brain. Neurochem Res 25:405-411
50. Nielsen AN, Fabricius M, Lauritzen M (2000) Scanning laser-Doppler flowmetry of rat cerebral circulation during cortical spreading depression. J Vasc Res 37:513-522
51. Nomura Y, Hazeki O, Tamura M (1997) Relationship between time-resolved and non-time-resolved Beer-Lambert law in turbid media. Phys Med Biol 42:1009-1022
52. Oleary MA, Boas DA, Chance B, Yodh AG (1995) Experimental images of heterogeneous turbid media by frequency-domain diffusing-Photon tomography. Opt Lett 20:426-428
53. Patterson M, Chance B, Wilson B (1989) Time resolve reflectance and transmittance for the noninvasive measurement of tissue optical properties. Appl Opt 28:2331-2336
54. Pogue BW, Paulsen KD (1998) High-resolution near-infrared tomographic imaging simulations of the rat cranium by use of apriori magnetic resonance imaging structural information. Opt Lett 23:1716-1718
55. Prahl S (2002) Optical absorption of hemoglobin. Oregon Medical Laser Center, Portland, OR
56. Ripoll J, Nieto-Vesperinas M, Arridge SR, Dehghani H (2000) Boundary conditions for light propagation in diffusive media with nonscattering regions. J Opt Soc Am A Opt Image Sci Vis 17:1671-1681
57. Schweiger M, Arridge SR (1999) Optical tomographic reconstruction in a complex head model using a priori region boundary information. Phys Med Biol 44:2703-2721
58. Siegel AM, Culver JP, Mandeville JB, Boas DA (2003) Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation. Phys Med Biol 48:1391-1403
59. Sorensen AG, Copen WA, Ostergaard L, Buonanno FS, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Koroshetz WJ (1999) Hyperacute stroke: Simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time. Radiology 210:519-527
60. Stankovic MR, Maulik D, Rosenfeld W, Stubblefield PG, Franceschini MA, Hueber D, Gratton E, Fantini S (1999) First RealTime optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets. Pediatr Res 45:2050
61. Takahashi K, Greenberg JH, Jackson P, Maclin K, Zhang J (1997) Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. J Cereb Blood Flow Metab 17:1137-1142
62. Villringer A, Chance B (1997) Non-invasive optical spectroscopy and imaging of human brain function. Trends Neurosci 20:435-442
63. Vinogradov SA, Lo LW, Jenkins WT, et al (1996) Noninvasive imaging of the distribution in oxygen in tissue in vivo using near-infrared phosphors. Biophys J 70:1609-1617
64. Weiss HR, Sinha AK, Lu XW (1996) Effect of up-regulation of NMDA receptors on cerebral O-2 consumption and blood flow in rat. Brain Res 730:193-198
65. Williams DS, Detre JA, Leigh JS, Koretsky AP (1992) Magnetic resonance imaging of perfusion using spin inversion of arterial water. PNAS 89:212-216
66. Wray S, Cope M, Delpy DT (1988) Characteristics of the near infrared absorption spectra of cytochrome aa3 and hemoglobin for the non-invasive monitoring of cerebral oxygenation. Biochim Biophys Acta 933:184-192
67. Zaharchuk G, Bogdanov AA Jr, Marota JJ, Shimizu-Sasamata M, Weisskoff RM, Kwong KK, Jenkins BG, Weissleder R, Rosen BR (1998) Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction. Magn Reson Med 40:666-678
68. Zaharchuk G, Yamada M, Sasamata M, Jenkins BG, Moskowitz MA, Rosen BR (2000) Is all perfusion-weighted magnetic resonance imaging for stroke equal? The temporal evolution of multiple hemodynamic parameters after focal ischemia in rats correlated with evidence of infarction. J Cereb Blood Flow Metab 20:1341-1351