Characterization of periinfarct flow transients with laser speckle and Doppler after middle cerebral artery occlusion in the rat

Journal of Neuroscience Research

Volumn 87, Issue 5, 2009, Pages 1219-1229

  Luckl, Janos ^a   Zhou, Chao ^a   Durduran, Turgut ^a   Yodh, Arjun G ^a   Greenberg, Joel H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Focal ischemia; Intraluminal suture model; Isoflurane; Optical imaging

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; FLOW MEASUREMENT; HISTOCHEMISTRY; HYPEREMIA; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC EXAMINATION; NONHUMAN; PERIINFARCT FLOW TRANSIENT; PRIORITY JOURNAL; RAT; RELIABILITY; REPERFUSION; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CEREBROVASCULAR CIRCULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; RHEOLOGY;

EID: 65949119522     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21933     Document Type: Article

References (47)

1. Ayata C, Shin HK, Salomone S, Ozdemir-Gursoy Y, Boas DA, Dunn AK, Moskowitz MA. 2004. Pronounced hypoperfusion during spreading depression in mouse cortex. J Cereb Blood Flow Metab 24:1172-1182.
2. Bandyopadhyay R, Gittings AS, Suh SS, Dixon PK, Durian DJ. 2005. Speckle-visibility spectroscopy: tool to study time-varying dynamics. Rev Sci Instrument 76:093110.
3. Bardutzky J, Shen Q, Henninger N, Bouley J, Duong TQ, Fisher M. 2005. Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging. Stroke 36:2000-2005.
4. Belayev L, Alonso OF, Busto R, Zhao W, Ginsberg MD. 1996. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke 27:1616-1622.
5. Branston NM, Strong AJ, Symon L. 1977. Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischaemia in baboon cerebral cortex. J Neurol Sci 32:305-321.
6. Briers JD. 2001. Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging. Physiol Meas 22:R35-R66.
7. Burnett MG, Shimazu T, Szabados T, Muramatsu H, Detre JA, Greenberg JH. 2006. Electrical forepaw stimulation during reversible forebrain ischemia decreases infarct volume. Stroke 37:1327-1331.
8. Dreier JP, Korner K, Gorner A, Lindauer U, Weih M, Villringer A, Dirnagl U. 1995. Nitric oxide modulates the CBF response to increased extracellular potassium. J Cereb Blood Flow Metab 15:914-919.
9. Dreier JP, Petzold G, Tille K, Lindauer U, Arnold G, Heinemann U, Einhaupl KM, Dirnagl U. 2001. Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats. J Physiol 531:515-526.
10. Dreier JP, Kleeberg J, Petzold G, Priller J, Windmuller O, Orzechowski HD, Lindauer U, Heinemann U, Einhaupl KM, Dirnagl U. 2002. Endothelin-1 potently induces Leao's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain 125:102-112.
11. Dreier JP, Kleeberg J, Alam M, Major S, Kohl-Bareis M, Petzold GC, Victorov I, Dirnagl U, Obrenovitch TP, Priller J. 2007. Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis. Exp Biol Med 232:204-213.
12. Dunn AK, Bolay H, Moskowitz MA, Boas DA. 2001. Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab 21:195-201.
13. Durduran T, Burnett MG, Yu G, Zhou C, Furuya D, Yodh AG, Detre JA, Greenberg JH. 2004. Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry. J Cereb Blood Flow Metab 24:518-525.
14. Fabricius M, Akgoren N, Lauritzen M. 1995. Arginine-nitric oxide pathway and cerebrovascular regulation in cortical spreading depression. Am J Physiol 269:H23-H29.
15. Fabricius M, Akgoren N, Dirnagl U, Lauritzen M. 1997. Laminar analysis of cerebral blood flow in cortex of rats by laser-Doppler flowmetry: a pilot study. J Cereb Blood Flow Metab 17:1326-1336.
16. Gerrits RJ, Raczynski C, Greene AS, Stein EA. 2000. Regional cerebral blood flow responses to variable frequency whisker stimulation: an autoradiographic analysis. Brain Res 864:205-212.
17. Goadsby PJ, Kaube H, Hoskin KL. 1992. Nitric oxide synthesis couples cerebral blood flow and metabolism. Brain Res 595:167-170.
18. Gold L, Back T, Arnold G, Dreier J, Einhaupl KM, Reuter U, Dirnagl U. 1998. Cortical spreading depression-associated hyperemia in rats: involvement of serotonin. Brain Res 783:188-193.
19. Goodman J. 1985. Statistical optics. Hoboken, NJ: John Wiley & Sons.
20. Graf R, Nakamura H, Vollmar S, Dohmen C, Sakowitz B, Bosche B, Dunn AK, Strong AJ. 2007. Cycling propagation of spontaneous spreading depolarizations around ischemic foci: evidence from experimental and clinical assessments. Society of Neuroscience, San Diego, CA Program No. 7659.
21. Hartings JA, Rolli ML, Lu XC, Tortella FC. 2003. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection. J Neurosci 23:11602-11610.
22. Hossmann KA. 1996. Periinfarct depolarizations. Cerebrovasc Brain Metab Rev 8:195-208.
23. Iijima T, Mies G, Hossmann KA. 1992. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab 12:727-733.
24. Jakobsson A, Nilsson GE. 1993. Prediction of sampling depth and photon pathlength in laser Doppler flowmetry. Med Biol Eng Comput 31:301-307.
25. Kariko K, Harris VA, Rangel Y, Duvall ME, Welsh FA. 1998. Effect of cortical spreading depression on the levels of mRNA coding for putative neuroprotective proteins in rat brain. J Cereb Blood Flow Metab 18:1308-1315.
26. Kharlamov A, Brown BR, Easley KA, Jones SC. 2004. Heterogeneous response of cerebral blood flow to hypotension demonstrated by laser speckle imaging flowmetry in rats. Neurosci Lett 368:151-156.
27. Leao AAP, Dusser de Barenne JG, Fulton JF, Gerard RW. 1944. Pial circulation and spreading depression of activity in the cerebral cortex. J Neurophysiol 7:391-396.
28. Luckl J, Keating J, Greenberg JH. 2008. Alpha-chloralose is a suitable anesthetic for chronic focal cerebral ischemia studies in the rat: a comparative study. Brain Res 1191:157-167.
29. Metea MR, Newman EA. 2006. Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. J Neurosci 26:2862-2870.
30. Nallet H, MacKenzie ET, Roussel S. 2000. Haemodynamic correlates of penumbral depolarization following focal cerebral ischaemia. Brain Res 879:122-129.
31. Parthasarathy AB, Tom WJ, Gopal A, Zhang X, Dunn AK. 2008. Robust flow measurements with multi-exposure speckle imaging. Optics Express 16.
32. Paxinos G, Watson C. 1982. The rat brain in stereotaxic coordinates. San Diego: Academic Press.
33. Pinard E, Nallet H, MacKenzie ET, Seylaz J, Roussel S. 2002. Penumbral microcirculatory changes associated with peri-infarct depolarizations in the rat. Stroke 33:606-612.
34. Reuter U, Weber JR, Gold L, Arnold G, Wolf T, Dreier J, Lindauer U, Dirnagl U. 1998. Perivascular nerves contribute to cortical spreading depression-associated hyperemia in rats. Am J Physiol 274:H1979-H1987.
35. Royl G, Leithner C, Sellien H, Muller JP, Megow D, Offenhauser N, Steinbrink J, Kohl-Bareis M, Dirnagl U, Lindauer U. 2006. Functional imaging with laser speckle contrast analysis: vascular compartment analysis and correlation with laser Doppler flowmetry and somatosensory evoked potentials. Brain Res 1121:95-103.
36. Scheckenbach KE, Dreier JP, Dirnagl U, Lindauer U. 2006. Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP. Exp Neurol 202:449-455.
37. Seitz I, Dirnagl U, Lindauer U. 2004. Impaired vascular reactivity of isolated rat middle cerebral artery after cortical spreading depression in vivo. J Cereb Blood Flow Metab 24:526-530.
38. Shen Q, Ren H, Cheng H, Fisher M, Duong TQ. 2005. Functional, perfusion and diffusion MRI of acute focal ischemic brain injury. J Cereb Blood Flow Metab 25:1265-1279.
39. Shimazu T, Inoue I, Araki N, Asano Y, Sawada M, Furuya D, Nagoya H, Greenberg JH. 2005. A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke 36:353-359.
40. Shin HK, Dunn AK, Jones PB, Boas DA, Moskowitz MA, Ayata C. 2006. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab 26:1018-1030.
41. Silva AC, Koretsky AP. 2002. Laminar specificity of functional MRI onset times during somatosensory stimulation in rat. Proc Natl Acad Sci U S A 99:15182-15187.
42. Strong AJ, Venables GS, Gibson G. 1983. The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 1. Topography of changes in blood flow, potassium ion activity, and EEG. J Cereb Blood Flow Metab 3:86-96.
43. Strong AJ, Bezzina EL, Anderson PJ, Boutelle MG, Hopwood SE, Dunn AK. 2006. Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations. J Cereb Blood Flow Metab 26:645-653.
44. Strong AJ, Anderson PJ, Watts HR, Virley DJ, Lloyd A, Irving EA, Nagafuji T, Ninomiya M, Nakamura H, Dunn AK, Graf R. 2007. Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex. Brain 130:995-1008.
45. Sukhotinsky I, Dilekoz E, Moskowitz MA, Ayata C. 2008. Hypoxia and hypotension transform the blood flow response to cortical spreading depression from hyperemia into hypoperfusion in the rat. J Cereb Blood Flow Metab 28:1369-1376.
46. Wang Z, Hughes S, Dayasundara S, Menon RS. 2007. Theoretical and experimental optimization of laser speckle contrast imaging for high specificity to brain microcirculation. J Cereb Blood Flow Metab 27: 258-269.
47. Zhou C, Shimazu T, Durduran T, Luckl J, Kimberg DY, Yu G, Chen XH, Detre JA, Yodh AG, Greenberg JH. 2008. Acute functional recovery of cerebral blood flow after forebrain ischemia in rat. J Cereb Blood Flow Metab 28:1275-1284.