KRAS p.G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines

Journal of Cancer Research and Clinical Oncology

Volumn 139, Issue 2, 2013, Pages 201-209

  Messner, Isabelle ^a   Cadeddu, Giuseppe ^a   Huckenbeck, Wolfgang ^a   Knowles, Helen J ^b   Gabbert, Helmut E ^a   Baldus, Stephan E ^a   Schaefer, Karl Ludwig ^a  

^a Department of Orthopedic Surgery   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

BRAF; Cetuximab; Colorectal adenocarcinoma; EGFR; KRAS; Panitumumab; PIK3CA

Indexed keywords

B RAF KINASE; BIOLOGICAL MARKER; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; K RAS PROTEIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; ANTINEOPLASTIC AGENT; BRAF PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; MONOCLONAL ANTIBODY; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN; RAS PROTEIN;

ARTICLE; BRAF GENE; CANCER CELL CULTURE; CANCER INHIBITION; CODON; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG RESISTANCE; DRUG RESPONSE; DRUG SENSITIVITY; EGFR GENE; GENE DOSAGE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOLECULARLY TARGETED THERAPY; MUTATIONAL ANALYSIS; ONCOGENE K RAS; PIK3CA GENE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; REGULATOR GENE; WILD TYPE; CELL PROLIFERATION; COLORECTAL TUMOR; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MUTATION; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

MLCS; MLOWN;

EID: 84874997620     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1319-7     Document Type: Article

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