Forming and inhibiting PRT active sites

Nature Structural Biology

Volumn 6, Issue 6, 1999, Pages 502-504

  Smith, Janet L ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; GUANINE; HYPOXANTHINE; NUCLEOTIDE; OROTIC ACID; PHOSPHORIBOSYL PYROPHOSPHATE; PHOSPHORIBOSYLTRANSFERASE; URACIL; XANTHINE;

CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME INHIBITION; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; SHORT SURVEY;

AMIDOPHOSPHORIBOSYLTRANSFERASE; ANIMALS; BINDING SITES; CATALYSIS; DIPHOSPHATES; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; HYDROGEN BONDING; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; METALS; MODELS, MOLECULAR; PHOSPHORIBOSYL PYROPHOSPHATE; PROTEIN CONFORMATION; PURINES; TRYPANOSOMA;

EID: 0033024577     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/9266     Document Type: Short Survey

References (13)

1. Krahn, J.M. et al. Biochemistry 36, 11061-11068 (1997).
2. Focia, P.C., Craig, S.P. & Eakin, A.E. Biochemistry 37, 17120-17127 (1998).
3. Shi, W. et al. Nature Struct. Biol. 6, 588-593 (1999).
4. Eads, J.C., Scapin, G., Xu, Y., Grubmeyer, C. & Sacchettini, J.C. Cell 78, 325-334 (1994).
5. Scapin G., Ozturk D.H., Grubmeyer C. & Sacchettini J.C. Biochemistry 34, 10744-10754 (1995).
6. Schumacher, M.A., Carter, D., Roos, D.S., Ullman, B. & Brennan, R.G. Nature Struct. Biol. 3, 881-887 (1996).
7. Somoza, J.R., Chin, M.S., Focia, P.J.,Wang. C.C. & Fletterick, R.J. Biochemistry 35, 7032-7040 (1996).
8. Henriksen, A., Aghajari, N., Jensen, K.F. & Gajhede, M. Biochemistry 35, 3803-3809 (1996).
9. Schumacher, M.A. et al. EMBO J. 17, 3219-3232 (1998).
10. Vos, S., Parry, R.J., Burns, M.R., de Jersey, J. & Martin, J.L. J. Mol. Biol. 282, 875-889 (1998).
11. Tomchick, D.R., Turner, R.J., Switzer, R.L & Smith, J.L. Structure 6, 337-350 (1998).
12. Eads, J.C, Ozturk, D., Wexler, T.B., Grubmeyer, C. & Sacchettini, J.C. Structure 5, 47-58 (1997).
13. Li, C.M. et al. Nature Struct. Biol. 6, 582-587 (1999).