Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis

Cellular Signalling

Volumn 25, Issue 5, 2013, Pages 1176-1185

  Xu, Yimiao ^a   Diao, Ying ^a   Qi, Shimei ^a   Pan, Xiaolong ^a   Wang, Qi ^a   Xin, Yinqiang ^a   Cao, Xiang ^a   Ruan, Jie ^a   Zhao, Zhihui ^a   Luo, Lan ^b   Liu, Chang ^a   Yin, Zhimin ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Apoptosis; Hsp27; P53; Phosphorylation

Indexed keywords

ATM PROTEIN; DOXORUBICIN; HEAT SHOCK PROTEIN 27; PROTEIN MDM2; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CELL STRAIN HEK293A; CELL STRAIN MCF 7; CELL SURVIVAL; DOWN REGULATION; EMBRYO; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN INDUCTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HEK293 CELLS; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MCF-7 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84874964149     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.01.017     Document Type: Article

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