Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model

European Journal of Immunology

Volumn 43, Issue 3, 2013, Pages 655-666

  Georgiev, Peter ^a   Belikoff, Bryan G ^a   Hatfield, Stephen ^a   Ohta, Akio ^a   Sitkovsky, Michail V ^a   Lukashev, Dmitriy ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Animal models; Cytokines; Hypoxia inducible factor; Sepsis; T lymphocytes

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA ISOFORM I.1; INTERLEUKIN 10; ISOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; BACTERIAL PERITONITIS; BLOOD; CELL CYCLE M PHASE; CELL POLARITY; CONTROLLED STUDY; DISEASE MODEL; GENE; GENE DELETION; GENE SILENCING; HYPOXIA INDUCIBLE FACTOR 1ALPHA ISOFORM I.1 GENE; IMMUNE RESPONSE; IMMUNITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; SEPSIS; SURVIVAL; T LYMPHOCYTE;

ANIMALS; BACTERIAL INFECTIONS; DISEASE MODELS, ANIMAL; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; PERITONITIS; PROTEIN ISOFORMS; RECEPTORS, ANTIGEN, T-CELL; SEPSIS; T-LYMPHOCYTES; TRANSCRIPTIONAL ACTIVATION;

EID: 84874952063     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242765     Document Type: Article

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