Dual asymmetric centrifugation as an alternative preparation method for parenteral fat emulsions in preformulation development

International Journal of Pharmaceutics

Volumn 447, Issue 1-2, 2013, Pages 31-37

  Tenambergen, Frederike ^a   Maruiama, Cintia H ^a   Mäder, Karsten ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Dual asymmetric centrifugation; Emulsion stability; Fat emulsions; Hemolytic activity; Static light scattering

Indexed keywords

EMULSIFYING AGENT; FAT DROPLET; LIPID EMULSION; SOYBEAN OIL;

ARTICLE; CENTRIFUGATION; DRUG STABILITY; DRUG SYNTHESIS; DUAL ASYMMETRIC CENTRIFUGATION; HEMOLYSIS; LIGHT SCATTERING; MEASUREMENT; NANOEMULSION; NANOFILTRATION; PARENTERAL DRUG ADMINISTRATION; PARTICLE SIZE; PREFORMULATION; PRIORITY JOURNAL; ZETA POTENTIAL;

CENTRIFUGATION; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ERYTHROCYTES; FAT EMULSIONS, INTRAVENOUS; HEMOLYSIS; HUMANS; OSMOLAR CONCENTRATION; PARENTERAL NUTRITION; SOYBEAN OIL;

EID: 84874937020     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.02.033     Document Type: Article

References (27)

1. J. Adrian, A. Wolf, A. Steinbach, J. Rössler, and R. Süss Targeted delivery to neuroblastoma of novel siRNA-anti-GD2-liposomes prepared by dual asymmetric centrifugation and sterol-based post-insertion method Pharm. Res. 2011 1 12
2. ®-Die Fettkomponente in OLIMEL 2010 Baxter Deutschland GmbH Unterschleißheim
3. ® 20% N 2007 B. Braun Melsungen AG Melsungen
4. S. Benita, and M.Y. Levy Submicron emulsions as colloidal drug carriers for intravenous administration: comprehensive physicochemical characterization J. Pharm. Sci. 82 1993 1069 1079
5. T.K. Bock, and B.W. Müller A novel assay to determine the hemolytic activity of drugs incorporated in colloidal carrier systems Pharm. Res. 11 1994 589 591
6. H. Bunjes Lipidsysteme zur parenteralen Anwendung-Nanoemulsionen und Lipidnanopartikel K. Mäder, U. Weidenauer, Innovative Arzneiformen 2010 Wissenschaftliche Verlagsgesellschaft Stuttgart 187 206
7. L. Collins-Gold, R. Lyons, and L. Bartholow Parenteral emulsions for drug delivery Adv. Drug Deliver. Rev. 5 1990 189 208
8. D. De Vleeschauwer, and P. Van der Meeren Colloid chemical stability and interfacial properties of mixed phospholipid-non-ionic surfactant stabilised oil-in-water emulsions Colloids Surf. A 152 1999 59 66
9. European Directorate for the Quality of Medicines and Health Care European Pharmacopoeia vol. 7.5 2012 EDQM - Council of Europe Strasbourg
10. C.B. Fox, S. Lin, S.J. Sivananthan, T.S. Dutill, K.T. Forseth, S.G. Reed, and T.S. Vedvick Effects of emulsifier concentration, composition, and order of addition in squalene-phosphatidylcholine oil-in-water emulsions Pharm. Dev. Technol. 16 2011 511 519
11. M. Grit, J.H. de Smidt, A. Struijke, and D.J. Crommelin Hydrolysis of phosphatidylcholine in aqueous liposome dispersions Int. J. Pharm. 50 1989 1 6
12. Hauschild & Co. KG Betriebsanleitung SpeedMixer DAC 150 SP 2008 Hauschild & Co. KG Hamm
13. K. Hippalgaonkar, S. Majumdar, and V. Kansara Injectable lipid emulsions-advancements, opportunities and challenges AAPS PharmSciTech 11 2010 1526 1540
14. M. Hirsch, V. Ziroli, M. Helm, and U. Massing Preparation of small amounts of sterile sirna-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC) J. Controlled Release 135 2009 80 88
15. F. Ishii, and Y. Nagasaka Interaction between erythrocytes and free phospholipids as an emulsifying agent in fat emulsions or drug carrier emulsions for intravenous injections Colloids Surf. B 37 2004 43 47
16. M. Jumaa, and B.W. Müller The stabilization of parenteral fat emulsion using non-ionic ABA copolymer surfactant Int. J. Pharm. 174 1998 29 37
17. M. Jumaa, and B.W. Müller In vitro investigation of the effect of various isotonic substances in parenteral emulsions on human erythrocytes Eur. J. Pharm. Sci. 9 1999 207 212
18. M. Jumaa, and B.W. Müller Lipid emulsions as a novel system to reduce the hemolytic activity of lytic agents: mechanism of the protective effect Eur. J. Pharm. Sci. 9 2000 285 290
19. V. Koster, P. Kuks, R. Lange, and H. Talsma Particle size in parenteral fat emulsions, what are the true limitations? Int. J. Pharm. 134 1996 235 238
20. J. Kuntsche, K. Klaus, and F. Steiniger Size determinations of colloidal fat emulsions: a comparative study J. Biomed. Nanotechnol. 5 2009 384 395
21. M. Levy, and S. Benita Design and characterization of a submicronized o/w emulsion of diazepam for parenteral use Int. J. Pharm 54 1989 103 112
22. Malvern Instruments Ltd. Sample Dispersion & Refractive Index Guide 1997 Malvern Instruments Ltd. Worcestershire, UK
23. U. Massing, S. Cicko, and V. Ziroli Dual asymmetric centrifugation (DAC)-a new technique for liposome preparation J. Controlled Release 125 2008 16 24
24. R. Morales Chabrand, H.J. Kim, C. Zhang, C. Glatz, and S. Jung Destabilization of the emulsion formed during aqueous extraction of soybean oil J. Am. Oil Chem. Soc. 85 2008 383 390
25. W. Tian, S. Schulze, M. Brandl, and G. Winter Vesicular phospholipid gel-based depot formulations for pharmaceutical proteins: development and in vitro evaluation J. Controlled Release 142 2010 319 325
26. C. Weingarten, N.S.S. Magalhaes, A. Baszkin, S. Benita, and M. Seiller Interactions of a non-ionic ABA copolymer surfactant with phospholipid monolayers: possible relevance to emulsion stabilization Int. J. Pharm. 75 1991 171 179
27. V.M. Weiss, T. Naolou, T. Groth, J. Kressler, and K. Mäder In vitro toxicity of stearol-poly(glycerol adipate) nanoparticles J. Appl. Biomater. Funct. Mater. 10 2012 163 169