In vitro toxicity of Stearoyl-poly(glycerol adipate) nanoparticles

Journal of Applied Biomaterials and Functional Materials

Volumn 10, Issue 3, 2012, Pages 163-169

  Weiss, Verena M ^a   Naolou, Toufik ^a   Groth, Thomas ^a   Kressler, Jörg ^a   Mäder, Karsten ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Biodegradable; Drug carriers; Hepg2 cells; Nanoparticles; Poly(glycerol adipate); Toxicity

Indexed keywords

BIODEGRADABLE POLYMERS; BLOOD; CELLS; CYTOLOGY; DRUG DELIVERY; GLYCEROL; PHOTON CORRELATION SPECTROSCOPY; TOXICITY;

ADIPATES; BIODEGRADABLE; CELL-BE; CELL/B.E; CELL/BE; DRUG CARRIER; HAEMOLYSIS; HEP-G2 CELLS; IN-VITRO; POLY(GLYCEROL ADIPATE);

NANOPARTICLES;

DRUG CARRIER; NANOPARTICLE; PGA BB; PGA S20; PGA S50; PGA S65; STEARIC ACID; STEAROYLPOLY(GLYCEROL ADIPATE) NANOPARTICLE; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; CELL METABOLISM; CELL PROLIFERATION; CELL SEPARATION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CYTOTOXICITY; ERYTHROCYTE; IN VITRO STUDY; INCUBATION TIME; NANOTOXICOLOGY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; SYNTHESIS; ZETA POTENTIAL;

EID: 84874277423     PISSN: None     EISSN: 22808000     Source Type: Journal    
DOI: 10.5301/JABFM.2012.10294     Document Type: Article

References (29)

1. Magenheim B, Levy MY, Benita S. A new in vitro technique for the evaluation of drug release profile from colloidal carriers ultrafiltration technique at low pressure. Int J Pharm 1993; 94: 115-23.
2. Westesen K, Bunjes H, Koch MHJ. Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. J Control Release 1997; 48: 223-36.
3. Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery a review of the state of the art. Eur J Pharm Biopharm 2000; 50: 161-77.
4. Govender T, Stolnik S, Garnett MC, Illum L, Davis SS. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J Control Release 1999; 57: 171-85.
5. Leo E, Brina B, Forni F, Vandelli MA. In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water soluble or insoluble form. Int J Pharm 2004; 278: 133-41.
6. Cascone MG, Pot PM, Lazzeri L, Zhu Z. Release of dexamethasone from PLGA nanoparticles entrapped into dextran/poly(vinyl alcohol) hydrogels. J Mater Sci Mater Med 2002; 13: 265-9.
7. Washington C, Evans K. Release rate measurements of model hydrophobic solutes from submicron triglyceride emulsions. J Control Release 1995; 33: 383-90.
8. Kallinteri P, Higgins S, Hutcheon GA, St Pourcain CB, Garnett MC. Novel functionalized biodegradable polymers for nanoparticle drug delivery systems. Biomacromolecules 2005; 6: 1885-94.
9. Weiss VM, Naolou T, Hause G, Kuntsche J, Kressler J, Mäder K. Poly(glycerol adipate)-fatty acid esters as versatile nano carriers: From nanocubes over ellipsoids to nanospheres. J Control Release 2012; 158: 156-64.
10. Weiss VM, Naolou T, Amado E, Busse K, Mäder K, Kressler J. Formation of structured polygonal nanoparticles by phase separated comb-like polymers. Macromol Rapid Commun 2012; 33: 35-40.
11. Robbens J, Vanparys C, Nobels I, et al. Eco-, geno-and human toxicology of bio-active nanoparticles for biomedical applications. Toxicology 2010; 269: 170-81.
12. Nemmar A, Vanbilloen H, Hoylaerts MF, Hoet PHM, Verbruggen A, Nemery B. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am J Respir Crit Care Med 2001; 164: 1665-8.
13. Dunn SE, Coombes AGA, Garnett MC, Davis SS, Davies MC, Illum L. In vitro cell interaction and in vivo biodistribution of poly(lactide-co-glycolide) nanospheres surface modified by poloxamer and poloxamine copolymers. J Control Release 1997; 44: 65-76.
14. Herath HMTU, Di Silvio L, Evans JRG. Biological evaluation of solid freeformed, hard tissue scaffolds for orthopedic applications. J Appl Biomater Biomech 2010; 8: 89-96.
15. Bio Chain. Protocol manual: cell viability assay kits. Newark, CA 94569, USA 2005.
16. O'Brien J, Wilson I, Orton T, Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 2000; 267: 5421-6.
17. Anoopkumar-Dukie S, Carey JB, Conere T, O'Sullivan E, van Pelt FN, Allshire A. Resazurin assay of radiation response in cultured cells. Br J Radiol 2005; 78: 945-7.
18. BioVision. Data Sheet: LDA-Cytotoxicity Assay Kit. Mountain View, CA 94043, USA 2007.
19. Naolou T, Busse K, Kressler J. Synthesis of well-defined graft copolymers by combination of enzymatic polycondensation and click chemistry. Biomacromolecules 2010; 11: 3660-7.
20. Kline BJ, Beckman EJ, Russell AJ. One-step biocatalytic synthesis of linear polyesters with pendant hydroxyl groups. J Am Chem Soc 1998; 120: 9475-80.
21. Niepel MS, Peschel D, Sisquella X, Planell JA, Groth T. pH-dependent modulation of fibroblast adhesion on multilayers composed of poly (ethylene imine) and heparin. Biomaterials 2009; 30: 4939-47.
22. Uyama H, Yaguchi S, Kobayashi S. Lipase-catalyzed poly-condensation of dicarboxylic acid-divinyl esters and glycols to aliphatic polyesters. J Polym Sci A Polym Chem 1999; 37: 2737-45.
23. Gref R, Luck M, Quellec P, et al. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B Biointerfaces 2000; 18: 301-13.
24. Gref R, Domb A, Quellec P, et al. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv Drug Deliv Rev 1995; 16: 215-33.
25. Kim D, El-Shall H, Dennis D, Morey T. Interaction of PLGA nanoparticles with human blood constituents. Colloids Surf B Biointerfaces 2005; 40: 83-91.
26. Nociari MM, Shalev A, Benias P, Russo C. A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods 1998; 213: 157-67.
27. Löbler M, Behrend D, Maletz R, Schmitz KP. Sample geometry influences the outcome of in vitro cytotoxicity tests. Adv Eng Mater 2008; 10: B72-6.
28. Ontko JA. Metabolism of free fatty acids in isolated liver cells. J Biol Chem 1972; 247: 1788-800.
29. Hawker KM, Johnson PRA, Hughes JM, Black JL. Interleu-kin-4 inhibits mitogen-induced proliferation of human air-way smooth muscle cells in culture. Am J Physiol Lung Cell Mol Physiol 1998; 275: L469-77.