Vesicular phospholipid gel-based depot formulations for pharmaceutical proteins: Development and in vitro evaluation

Journal of Controlled Release

Volumn 142, Issue 3, 2010, Pages 319-325

  Tian, W ^a   Schulze, S ^a   Brandl, M ^b,c   Winter, G ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF TROMSØ   (Norway)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Dual asymmetric centrifugation; Erythropoietin; Sustained release; Vesicular phospholipid gels

Indexed keywords

ALTERNATIVE DELIVERY SYSTEM; CONTROLLING MECHANISM; EROSION KINETICS; ERYTHROPOIETIN; EXTRACTION METHOD; EXTRACTION PROTOCOLS; IN-VITRO EVALUATION; LINEAR KINETICS; LIPID CHARGE; LIPID CONTENT; MATRIX; MODEL PROTEINS; PHARMACEUTICAL PROTEIN; PROTEIN DRUGS; PROTEIN STABILITY; RELEASE BEHAVIORS; SDS-PAGE ANALYSIS; SUSTAINED RELEASE; THERAPEUTIC PROTEIN; VESICULAR PHOSPHOLIPID GELS;

CENTRIFUGATION; CENTRIFUGES; DRUG PRODUCTS; GELS; ORGANIC SOLVENTS; PHOSPHOLIPIDS; SOAPS (DETERGENTS); SOLVENT EXTRACTION;

PROTEINS;

CHLOROFORM; DETERGENT; ERYTHROPOIETIN; LIPID; ORGANIC SOLVENT; PROTEIN;

ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG SCREENING; EXTRACTION; IN VITRO STUDY; MACROMOLECULE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STABILITY; VESICULAR PHOSPHOLIPID GEL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; ERYTHROPOIETIN, RECOMBINANT; GELS; HUMANS; PARTICLE SIZE; PHOSPHOLIPIDS; PROTEIN STABILITY; RHEOLOGY; SOLUBILITY; SURFACE PROPERTIES;

EID: 77349108594     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.11.006     Document Type: Article

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