Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury

Journal of Controlled Release

Volumn 167, Issue 3, 2013, Pages 248-255

  Tsurkan, Mikhail V ^a,b,c,f,g   Hauser, Peter V ^d,e   Zieris, Andrea ^a,b,c   Carvalhosa, Raquel ^d,e   Bussolati, Benedetta ^d,e   Freudenberg, Uwe ^a,b,c   Camussi, Giovanni ^d,e   Werner, Carsten ^a,b,c  

^a LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN   (Germany)

^b Max Bergmann Center of Biomaterials Dresden   (Germany)

^c CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^d UNIVERSITY OF TURIN   (Italy)

^e UNIVERSITY OF TURIN   (Italy)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute kidney injury; Growth factor delivery; Heparin hydrogel; In situ regeneration; Regenerative medicine; Renal therapy

Indexed keywords

ACUTE KIDNEY INJURY; BASIC FIBROBLAST GROWTH FACTOR; EFFECTIVE APPROACHES; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTORS; GROWTH FACTOR DELIVERY; REGENERATIVE MEDICINE; RENAL THERAPY;

AGGREGATES; BIOASSAY; CELL PROLIFERATION; MEDICAL APPLICATIONS; POLYSACCHARIDES; TISSUE; TISSUE REGENERATION;

HYDROGELS;

HEPARIN; MACROGOL; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR; RECOMBINANT EPIDERMAL GROWTH FACTOR;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW KINETICS; HISTOLOGY; HYDROGEL; IN VIVO STUDY; LASER MICROSCOPY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHABDOMYOLYSIS; TISSUE REGENERATION; VISCOELASTICITY;

ACUTE KIDNEY INJURY; ANIMALS; CELL PROLIFERATION; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GLYCEROL; HEPARIN; HYDROGELS; KIDNEY TUBULES; MALE; MICE; MICE, INBRED C57BL; POLYETHYLENE GLYCOLS; REGENERATION;

EID: 84874936138     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.01.030     Document Type: Article

References (49)

1. M.H. Little Regrow or repair: potential regenerative therapies for the kidney J. Am. Soc. Nephrol. 17 2006 2390 2401
2. K. Lee, E.A. Silva, and D.J. Mooney Growth factor delivery-based tissue engineering: general approaches and a review of recent developments J. R. Soc. Interface 8 2011 153 170
3. R. Vasita, and D.S. Katti Growth factor-delivery systems for tissue engineering: a materials perspective Expert Rev. Med. Devices 3 2006 29 47
4. K.N. Ekdahl, J.D. Lambris, H. Elwing, D. Ricklin, P.H. Nilsson, Y. Teramura, I.A. Nicholls, and B. Nilsson Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies Adv. Drug Deliv. Rev. 63 2011 1042 1050
5. I. Capila, and R.J. Linhardt Heparin-protein interactions Angew. Chem. Int. Ed. 41 2002 390 412
6. D.S. Benoit, A.R. Durney, and K.S. Anseth The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation Biomaterials 28 2007 66 77
7. S.H. Kim, and K.L. Kiick Heparin-mimetic sulfated peptides with modulated affinities for heparin-binding peptides and growth factors Peptides 28 2007 2125 2136
8. T. Nie, A. Baldwin, N. Yamaguchi, and K.L. Kiick Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems J. Control. Release 122 2007 287 296
9. I. Strehin, Z. Nahas, K. Arora, T. Nguyen, and J. Elisseeff A versatile pH sensitive chondroitin sulfate-PEG tissue adhesive and hydrogel Biomaterials 31 2010 2788 2797
10. G. Tae, Y.J. Kim, W.I. Choi, M. Kim, P.S. Stayton, and A.S. Hoffman Formation of a novel heparin-based hydrogel in the presence of heparin-binding biomolecules Biomacromolecules 8 2007 1979 1986
11. X. Zheng Shu, Y. Liu, F.S. Palumbo, Y. Luo, and G.D. Prestwich In situ crosslinkable hyaluronan hydrogels for tissue engineering Biomaterials 25 2004 1339 1348
12. M. Fujita, M. Ishihara, M. Simizu, K. Obara, T. Ishizuka, Y. Saito, H. Yura, Y. Morimoto, B. Takase, T. Matsui, M. Kikuchi, and T. Maehara Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel Biomaterials 25 2004 699 706
13. M. Ishihara, K. Obara, T. Ishizuka, M. Fujita, M. Sato, K. Masuoka, Y. Saito, H. Yura, T. Matsui, H. Hattori, M. Kikuchi, and A. Kurita Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization J. Biomed. Mater. Res. A 64 2003 551 559
14. D.B. Pike, S. Cai, K.R. Pomraning, M.A. Firpo, R.J. Fisher, X.Z. Shu, G.D. Prestwich, and R.A. Peattie Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF Biomaterials 27 2006 5242 5251
15. U. Freudenberg, A. Hermann, P.B. Welzel, K. Stirl, S.C. Schwarz, M. Grimmer, A. Zieris, W. Panyanuwat, S. Zschoche, D. Meinhold, A. Storch, and C. Werner A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases Biomaterials 30 2009 5049 5060
16. P.B. Welzel, S. Prokoph, A. Zieris, M. Grimmer, S. Zschoche, U. Freudenberg, and C. Werner Modulating biofunctional starPEG heparin hydrogels by varying size and ratio of the constituents Polymers 3 2011 602 620
17. A. Zieris, S. Prokoph, K.R. Levental, P.B. Welzel, M. Grimmer, U. Freudenberg, and C. Werner FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis Biomaterials 31 2010 7985 7994
18. A. Zieris, S. Prokoph, P.B. Welzel, M. Grimmer, K.R. Levental, W. Panyanuwat, U. Freudenberg, and C. Werner Analytical approaches to uptake and release of hydrogel-associated FGF-2 J. Mater. Sci. Mater. Med. 21 2010 915 923
19. J. Cerda, N. Lameire, P. Eggers, N. Pannu, S. Uchino, H. Wang, A. Bagga, and A. Levin Epidemiology of acute kidney injury Clin. J. Am. Soc. Nephrol. 3 2008 881 886
20. M. Tonelli, B. Manns, and D. Feller-Kopman Acute renal failure in the intensive care unit: a systematic review of the impact of dialytic modality on mortality and renal recovery Am. J. Kidney Dis. 40 2002 875 885
21. K.D. Liu, and P.R. Brakeman Renal repair and recovery Crit. Care Med. 36 2008 S187 S192
22. L.C. Racusen The morphologic basis of acute renal failure Acute Renal Failure: A Comparison to Brenner and Rector's The Kidney 2001 1 12
23. M.B. Herrera, B. Bussolati, S. Bruno, V. Fonsato, G.M. Romanazzi, and G. Camussi Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury Int. J. Mol. Med. 14 2004 1035 1041
24. M. Morigi, B. Imberti, C. Zoja, D. Corna, S. Tomasoni, M. Abbate, D. Rottoli, S. Angioletti, A. Benigni, N. Perico, M. Alison, and G. Remuzzi Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure J. Am. Soc. Nephrol. 15 2004 1794 1804
25. B.D. Humphreys, and J.V. Bonventre The contribution of adult stem cells to renal repair Nephrol. Ther. 3 2007 3 10
26. S. Bruno, C. Grange, M.C. Deregibus, R.A. Calogero, S. Saviozzi, F. Collino, L. Morando, A. Busca, M. Falda, B. Bussolati, C. Tetta, and G. Camussi Mesenchymal stem cell-derived microvesicles protect against acute tubular injury J. Am. Soc. Nephrol. 20 2009 1053 1067
27. E.J. Sharples Acute kidney injury: stimulation of repair Curr. Opin. Crit. Care 13 2007 652 655
28. S. Wang, and R. Hirschberg Role of growth factors in acute renal failure Nephrol. Dial. Transplant. 12 1997 1560 1563
29. T. Takahashi, U. Huynh-Do, and T.O. Daniel Renal microvascular assembly and repair: power and promise of molecular definition Kidney Int. 53 1998 826 835
30. F.P. Schena Role of growth factors in acute renal failure Kidney Int. Suppl. 66 1998 S11 S15
31. E.J. Nouwen, W.A. Verstrepen, and M.E. De Broe Epidermal growth factor in acute renal failure Ren. Fail. 16 1994 49 60
32. R.J. Anderson, and C.J. Ray Potential autocrine and paracrine mechanisms of recovery from mechanical injury of renal tubular epithelial cells Am. J. Physiol. 274 1998 F463 F472
33. G.T. Montelione, K. Wuthrich, A.W. Burgess, E.C. Nice, G. Wagner, K.D. Gibson, and H.A. Scheraga Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints Biochemistry 31 1992 236 249
34. H.D. Humes, D.A. Cieslinski, T.M. Coimbra, J.M. Messana, and C. Galvao Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure J. Clin. Invest. 84 1989 1757 1761
35. P.V. Hauser, R. De Fazio, S. Bruno, S. Sdei, C. Grange, B. Bussolati, C. Benedetto, and G. Camussi Stem cells derived from human amniotic fluid contribute to acute kidney injury recovery Am. J. Pathol. 177 2010 2011 2021
36. M.B. Herrera, B. Bussolati, S. Bruno, L. Morando, G. Mauriello-Romanazzi, F. Sanavio, I. Stamenkovic, L. Biancone, and G. Camussi Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury Kidney Int. 72 2007 430 441
37. A. Karihaloo, C. Nickel, and L.G. Cantley Signals which build a tubule Nephron Exp. Nephrol. 100 2005 e40 e45
38. M.A. Meyers, and K.K. Chawla Mechanical Behavior of Materials Second edition 2009 Cambridge University Press Cambridge
39. I. Levental, P.C. Georges, and P.A. Janmey Soft biological materials and their impact on cell function Soft Matter 3 2007 299 306
40. A. Omari, R. Tabary, D. Rousseau, F.L. Calderon, J. Monteil, and G. Chauveteau Soft water-soluble microgel dispersions: structure and rheology J. Colloid Interface Sci. 302 2006 537 546
41. P.K. Vemula, E. Boilard, A. Syed, N.R. Campbell, M. Muluneh, D.A. Weitz, D.M. Lee, and J.M. Karp On-demand drug delivery from self-assembled nanofibrous gels: a new approach for treatment of proteolytic disease J. Biomed. Mater. Res. A 97 2011 103 110
42. G.A. Tanner Experimental models of acute tubular necrosis S.R.A.a.J.A. Thornhill, CRC Handbook of Animal Models of Renal Failure 1985 CRC Press Boca Raton, FL 109 144
43. X. Bosch, E. Poch, and J.M. Grau Rhabdomyolysis and acute kidney injury N. Engl. J. Med. 361 2009 62 72
44. J.L. Countaway, A.C. Nairn, and R.J. Davis Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase J. Biol. Chem. 267 1992 1129 1140
45. W. Yang, R.F. Barth, R. Leveille, M. Ciesielski, R.A. Fenstermaker, and J. Capala Evaluation of systemically administered radiolabeled epidermal growth factor as a brain tumor targeting agent J. Neurooncol. 55 2001 19 28
46. A. Zieris, K. Chwalek, S. Prokoph, K.R. Levental, P.B. Welzel, U. Freudenberg, and C. Werner Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels J. Control. Release 156 2011 28 36
47. K. Chwalek, K.R. Levental, M.V. Tsurkan, A. Zieris, U. Freudenberg, and C. Werner Two-tier hydrogel degradation to boost endothelial cell morphogenesis Biomaterials 32 2011 9649 9657
48. M.V. Tsurkan, K. Chwalek, K.R. Levental, U. Freudenberg, and C. Werner Modular StarPEG-Heparin Gels with Bifunctional Peptide Linkers Macromol. Rapid Commun. 31 2010 1529 1533
49. M.V. Tsurkan, K.R. Levental, U. Freudenberg, and C. Werner Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties Chem. Commun. (Camb.) 46 2010 1141 1143