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Kinetics and characterization of initially regenerating proximal tubules in S3 segment in response to various degrees of acute tubular injury
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Vogetseder A, Palan T, Bacic D, et al. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. Am J Physiol Cell Physiol 2007; 292:C807-C813. An important study of the normal cycling of epithelial cells in the proximal tubule, which provides insights into the origin of cells after tubular injury.
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Villanueva S, Cespedes C, Gonzalez A, Vio CP. bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure. Am J Physiol Regul Integr Comp Physiol 2006; 291:R1677-R1687. The role of growth factors in the initiation of a proliferative repair programme has been studied, but the molecular examination of genes upregulated early after injury by fibroblast growth factor in this paper is leading a new direction of study.
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Togel F, Weiss K, Yang Y, et al. Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol 2007; 292:F1626-F1635. The role of stem cells in the repair of the adult kidney as in other organs has been questioned. In this study, the authors demonstrate the important role of circulating stem cells in creating an environment that promotes the repair process.
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