Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratory capacity in head and neck squamous cell carcinomas

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Bernaldo de Quirós, Sandra ^a   Merlo, Anna ^a   Secades, Pablo ^a   Zambrano, Iriana ^a   de Santa María, Ines Saenz ^a   Ugidos, Nerea ^a   Jantus Lewintre, Eloisa ^b   Sirera, Rafael ^c   Suarez, Carlos ^a   Chiara, María Dolores ^a  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

Gene amplification; Head and neck squamous cell carcinoma; Invasion; TRPC6

Indexed keywords

MESSENGER RNA; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6;

AMPLICON; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHROMOSOME 11Q; CHROMOSOME 18P; CHROMOSOME 19P; CHROMOSOME 21Q; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE AMPLIFICATION; GENE DOSAGE; GENE IDENTIFICATION; GENE INACTIVATION; GENE LOCATION; GENE OVEREXPRESSION; GENE TARGETING; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; REAL TIME POLYMERASE CHAIN REACTION; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6 GENE;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 11; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HEAD AND NECK NEOPLASMS; HUMANS; NEOPLASM INVASIVENESS; TRPC CATION CHANNELS; TUMOR MARKERS, BIOLOGICAL;

EID: 84874935899     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-116     Document Type: Article

References (50)

1. Akervall J. Genomic screening of head and neck cancer and its implications for therapy planning. Eur Arch Otorhinolaryngol 2006, 263:297-304. 10.1007/s00405-006-1039-1, 16575584.
2. Squire JA, Bayani J, Luk C, Unwin L, Tokunaga J, MacMillan C, Irish J, Brown D, Gullane P, Kamel-Reid S. Molecular cytogenetic analysis of head and neck squamous cell carcinoma: by comparative genomic hybridization, spectral karyotyping, and expression array analysis. Head Neck 2002, 24:874-887. 10.1002/hed.10122, 12211052.
3. Perez-Ordonez B, Beauchemin M, Jordan RC. Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol 2006, 59:445-453. 10.1136/jcp.2003.007641, 1860277, 16644882.
4. Tan KD, Zhu Y, Tan HK, Rajasegaran V, Aggarwal A, Wu J, Wu HY, Hwang J, Lim DT, Soo KC, Tan P. Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma. Genes Chromosomes Cancer 2008, 47:353-362. 10.1002/gcc.20539, 18196592.
5. Rodrigo JP, Garcia LA, Ramos S, Lazo PS, Suarez C. EMS1 Gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. Clin Cancer Res 2000, 6:3177-3182.
6. Callender T, el-Naggar AK, Lee MS, Frankenthaler R, Luna MA, Batsakis JG. PRAD-1 (CCND1)/cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma. Cancer 1994, 74:152-158. 10.1002/1097-0142(19940701)74:1<152::AID-CNCR2820740124>3.0.CO;2-K, 8004570.
7. Huang X, Gollin SM, Raja S, Godfrey TE. High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Natl Acad Sci U S A 2002, 99:11369-11374. 10.1073/pnas.172285799, 123263, 12172009.
8. Gorogh T, Weise JB, Holtmeier C, Rudolph P, Hedderich J, Gottschlich S, Hoffmann M, Ambrosch P, Csiszar K. Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma. J Pathol 2007, 212:74-82. 10.1002/path.2137, 17354256.
9. Begum A, Imoto I, Kozaki K, Tsuda H, Suzuki E, Amagasa T, Inazawa J. Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 In oral squamous-cell carcinoma. Cancer Sci 2009, 100:1908-1916. 10.1111/j.1349-7006.2009.01252.x, 19594544.
10. Secades P, Rodrigo JP, Hermsen M, Alvarez C, Suarez C, Chiara MD. Increase in gene dosage is a mechanism of HIF-1alpha constitutive expression in head and neck squamous cell carcinomas. Genes Chromosomes Cancer 2009, 48:441-454. 10.1002/gcc.20652, 19235921.
11. Singh B, Gogineni SK, Sacks PG, Shaha AR, Shah JP, Stoffel A, Rao PH. Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification. Cancer Res 2001, 61:4506-4513.
12. Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL. Multiple microalterations detected at high frequency in oral cancer. Cancer Res 2005, 65:7561-7567.
13. Roman E, Meza-Zepeda LA, Kresse SH, Myklebost O, Vasstrand EN, Ibrahim SO. Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization. Oncol Rep 2008, 20:825-843.
14. Weber RG, Sommer C, Albert FK, Kiessling M, Cremer T. Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization. Lab Invest 1996, 74:108-119.
15. Knuutila S, Bjorkqvist AM, Autio K, Tarkkanen M, Wolf M, Monni O, Szymanska J, Larramendy ML, Tapper J, Pere H. DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. Am J Pathol 1998, 152:1107-1123. 1858578, 9588877.
16. Menghi-Sartorio S, Mandahl N, Mertens F, Picci P, Knuutila S. DNA copy number amplifications in sarcomas with homogeneously staining regions and double minutes. Cytometry 2001, 46:79-84. 10.1002/cyto.1068, 11309816.
17. Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S, Inazawa J. Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res 2002, 62:4860-4866.
18. Dai Z, Zhu WG, Morrison CD, Brena RM, Smiraglia DJ, Raval A, Wu YZ, Rush LJ, Ross P, Molina JR. A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes. Hum Mol Genet 2003, 12:791-801. 10.1093/hmg/ddg083, 12651874.
19. Bashyam MD, Bair R, Kim YH, Wang P, Hernandez-Boussard T, Karikari CA, Tibshirani R, Maitra A, Pollack JR. Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer. Neoplasia 2005, 7:556-562. 10.1593/neo.04586, 1501288, 16036106.
20. Helias-Rodzewicz Z, Perot G, Chibon F, Ferreira C, Lagarde P, Terrier P, Coindre JM, Aurias A. YAP1 And VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas. Genes Chromosomes Cancer 2010, 49:1161-1171. 10.1002/gcc.20825, 20842732.
21. Fernandez LA, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor MD, Kenney AM. YAP1 Is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates sonic hedgehog-driven neural precursor proliferation. Genes Dev 2009, 23:2729-2741. 10.1101/gad.1824509, 2788333, 19952108.
22. Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T, Inazawa J. YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis 2010, 32:389-398.
23. Chigurupati S, Venkataraman R, Barrera D, Naganathan A, Madan M, Paul L, Pattisapu JV, Kyriazis GA, Sugaya K, Bushnev S. Receptor channel TRPC6 is a key mediator of notch-driven glioblastoma growth and invasiveness. Cancer Res 2010, 70:418-427. 10.1158/0008-5472.CAN-09-2654, 20028870.
24. Ding X, He Z, Zhou K, Cheng J, Yao H, Lu D, Cai R, Jin Y, Dong B, Xu Y, Wang Y. Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. J Natl Cancer Inst 2010, 102:1052-1068. 10.1093/jnci/djq217, 20554944.
25. Lansford CDGR, Bier H. Head and neck cancers 1999, Dordrecht: Kluwer Academic Press.
26. van den Ijssel P, Tijssen M, Chin SF, Eijk P, Carvalho B, Hopmans E, Holstege H, Bangarusamy DK, Jonkers J, Meijer GA. Human and mouse oligonucleotide-based array CGH. Nucleic Acids Res 2005, 33:e192. 10.1093/nar/gni191, 1316119, 16361265.
27. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
28. Gollin SM. Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. Head Neck 2001, 23:238-253. 10.1002/1097-0347(200103)23:3<238::AID-HED1025>3.0.CO;2-H, 11428456.
29. Smeets SJ, Braakhuis BJ, Abbas S, Snijders PJ, Ylstra B, van de Wiel MA, Meijer GA, Leemans CR, Brakenhoff RH. Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus. Oncogene 2006, 25:2558-2564. 10.1038/sj.onc.1209275, 16314836.
30. Snijders AM, Schmidt BL, Fridlyand J, Dekker N, Pinkel D, Jordan RC, Albertson DG. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene 2005, 24:4232-4242. 10.1038/sj.onc.1208601, 15824737.
31. Canel M, Secades P, Garzon-Arango M, Allonca E, Suarez C, Serrels A, Frame M, Brunton V, Chiara MD. Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression. Br J Cancer 2008, 98:1274-1284. 10.1038/sj.bjc.6604286, 2359633, 18349846.
32. Canel M, Secades P, Rodrigo JP, Cabanillas R, Herrero A, Suarez C, Chiara MD. Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak gene copy number. Clin Cancer Res 2006, 12:3272-3279. 10.1158/1078-0432.CCR-05-1583, 16740747.
33. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006, 10:515-527. 10.1016/j.ccr.2006.10.008, 2730521, 17157791.
34. Jarvinen AK, Autio R, Kilpinen S, Saarela M, Leivo I, Grenman R, Makitie AA, Monni O. High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx. Genes Chromosomes Cancer 2008, 47:500-509. 10.1002/gcc.20551, 18314910.
35. Lockwood WW, Chari R, Coe BP, Girard L, Macaulay C, Lam S, Gazdar AF, Minna JD, Lam WL. DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. Oncogene 2008, 27:4615-4624. 10.1038/onc.2008.98, 2849646, 18391978.
36. Weber A, Hengge UR, Stricker I, Tischoff I, Markwart A, Anhalt K, Dietz A, Wittekind C, Tannapfel A. Protein microarrays for the detection of biomarkers in head and neck squamous cell carcinomas. Hum Pathol 2007, 38:228-238. 10.1016/j.humpath.2006.07.012, 17020778.
37. Pacheco MM, Kowalski LP, Nishimoto IN, Brentani MM. Differential expression of c-jun and c-fos mRNAs in squamous cell carcinoma of the head and neck: associations with uPA, gelatinase B, and matrilysin mRNAs. Head Neck 2002, 24:24-32. 10.1002/hed.10009, 11774399.
38. Xie M, Sun Y, Li Y. Expression of matrix metalloproteinases in supraglottic carcinoma and its clinical implication for estimating lymph node metastases. Laryngoscope 2004, 114:2243-2248. 10.1097/01.mlg.0000149467.18822.59, 15564854.
39. Werner JA, Rathcke IO, Mandic R. The role of matrix metalloproteinases in squamous cell carcinomas of the head and neck. Clin Exp Metastasis 2002, 19:275-282. 10.1023/A:1015531319087, 12090467.
40. Zhang L, Ye DX, Pan HY, Wei KJ, Wang LZ, Wang XD, Shen GF, Zhang ZY. Yes-associated protein promotes cell proliferation by activating Fos related activator-1 in oral squamous cell carcinoma. Oral Oncol 2011, 47:693-697. 10.1016/j.oraloncology.2011.06.003, 21708480.
41. Yokoyama T, Osada H, Murakami H, Tatematsu Y, Taniguchi T, Kondo Y, Yatabe Y, Hasegawa Y, Shimokata K, Horio Y. YAP1 Is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation. Carcinogenesis 2008, 29:2139-2146. 10.1093/carcin/bgn200, 18725387.
42. Diep CH, Zucker KM, Hostetter G, Watanabe A, Hu C, Munoz RM, Von Hoff DD, Han H. Down-regulation of Yes associated protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. PLoS One 7:e32783.
43. Kang W, Tong JH, Chan AW, Lee TL, Lung RW, Leung PP, So KK, Wu K, Fan D, Yu J. Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. Clin Cancer Res 2011, 17:2130-2139. 10.1158/1078-0432.CCR-10-2467, 21346147.
44. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A 2006, 103:12405-12410. 10.1073/pnas.0605579103, 1533802, 16894141.
45. Guilbert A, Dhennin-Duthille I, Hiani YE, Haren N, Khorsi H, Sevestre H, Ahidouch A, Ouadid-Ahidouch H. Expression of TRPC6 channels in human epithelial breast cancer cells. BMC Cancer 2008, 8:125. 10.1186/1471-2407-8-125, 2409351, 18452628.
46. Yue D, Wang Y, Xiao JY, Wang P, Ren CS. Expression of TRPC6 in benign and malignant human prostate tissues. Asian J Androl 2009, 11:541-547. 10.1038/aja.2009.53, 19701218.
47. Cai R, Ding X, Zhou K, Shi Y, Ge R, Ren G, Jin Y, Wang Y. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. Int J Cancer 2009, 125:2281-2287. 10.1002/ijc.24551, 19610066.
48. Shi Y, Ding X, He ZH, Zhou KC, Wang Q, Wang YZ. Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. Gut 2009, 58:1443-1450. 10.1136/gut.2009.181735, 19651628.
49. Thebault S, Flourakis M, Vanoverberghe K, Vandermoere F, Roudbaraki M, Lehen'kyi V, Slomianny C, Beck B, Mariot P, Bonnal JL. Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res 2006, 66:2038-2047. 10.1158/0008-5472.CAN-05-0376, 16489003.
50. El Boustany C, Bidaux G, Enfissi A, Delcourt P, Prevarskaya N, Capiod T. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology 2008, 47:2068-2077. 10.1002/hep.22263, 18506892.