Definition of formulation design space, in vitro bioactivity and in vivo biodistribution for hydrophilic drug loaded PLGA/PEO-PPO-PEO nanoparticles using OFAT experiments

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 1, 2013, Pages 65-80

  Simonoska Crcarevska, M ^a   Geskovski, N ^a   Calis, S ^b   Dimchevska, S ^a   Kuzmanovska, S ^a   Petrusevski G ^c   Kajdzanoska M ^c   Ugarkovic, S ^c   Goracinova, K ^a  

^a SS CYRIL AND METHODIUS UNIVERSITY   (Macedonia)

^b Haccetepe University   (Turkey)

^c Research and Development   (Macedonia)

Author keywords

Irinotecan hydrochloride; Nanoparticles; PEO PPO PEO; PLGA; Tumor targeting

Indexed keywords

IRINOTECAN; NANOPARTICLE; POLOXAMER; POLYGLACTIN; POLYLACTIC ACID; CAMPTOTHECIN; LACTIC ACID; MACROGOL DERIVATIVE; PEO-PPO-PEO; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; PROPANEDIOL DERIVATIVE;

ARTICLE; BINDING KINETICS; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CHEMICAL INTERACTION; CIRCULATION; COLORECTAL CARCINOMA; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; EVAPORATION; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; SCANNING ELECTRON MICROSCOPY; SURFACE CHARGE; ZETA POTENTIAL; ADSORPTION; ANALOGS AND DERIVATIVES; ANIMAL; CACO 2 CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; MALE; RAT; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; TIME; TISSUE DISTRIBUTION; TUMOR CELL CULTURE; WISTAR RAT;

ADSORPTION; ANIMALS; CACO-2 CELLS; CAMPTOTHECIN; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTIC ACID; MALE; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; PROPYLENE GLYCOLS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 84874932049     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.02.004     Document Type: Article

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