Premature drug release of polymeric micelles and its effects on tumor targeting

International Journal of Pharmaceutics

Volumn 445, Issue 1-2, 2013, Pages 117-124

  Miller, Tobias ^a,c,d   Breyer, Sandra ^b   Van Colen, Gwenaelle ^a   Mier, Walter ^b   Haberkorn, Uwe ^b   Geissler, Simon ^a   Voss, Senta ^a   Weigandt, Markus ^a   Goepferich, Achim ^c  

^a MERCK KGAA   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Bioimaging; EPR effect; Organ distribution; Polymeric micelles; Premature release; Tumor accumulation

Indexed keywords

DECHLORO 4 IODO FENOFIBRATE; FENOFIBRATE; INDIUM 111; IODINE 125; IODINE 131; PEGYLATED POLY DEXTRO LEVO LACTIC ACID; POLYMER; TETRAXETAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TARGETING; DRUG TUMOR LEVEL; FEMALE; HYDROPHOBICITY; MICELLE; MOUSE; NONHUMAN; PREMATURE DRUG RELEASE; PRIORITY JOURNAL; RAT;

ANIMALS; CELL LINE, TUMOR; DRUG CARRIERS; FEMALE; FENOFIBRATE; MICE; MICELLES; NEOPLASMS; POLYETHYLENE GLYCOLS; RATS; TISSUE DISTRIBUTION;

EID: 84874923983     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.01.059     Document Type: Article

References (48)

1. F. Alexis, E.M. Pridgen, R. Langer, and O.C. Farokhzad Nanoparticle technologies for cancer therapy Handb. Exp. Pharmacol. 197 2010 55 86
2. H.M. Aliabadi, D.R. Brocks, P. Mahdipoor, and A. Lavasanifar A novel use of an in vitro method to predict the in vivo stability of block copolymer based nano-containers J. Control. Release 122 2007 63 70
3. H.M. Aliabadi, M. Shahin, D.R. Brocks, and A. Lavasanifar Disposition of drugs in block copolymer micelle delivery systems: from discovery to recovery Clin. Pharmacokinet. 47 2008 619 634
4. C. Allen, D. Maysinger, and A. Eisenberg Nano-engineering block copolymer aggregates for drug delivery Colloids Surf. B: Biointerfaces 16 1999 3 27
5. A.D. Bao, B. Goins, R. Klipper, G. Negrete, and W.T. Phillips Direct Tc-99m labeling of pegylated liposomal doxorubicin (Doxil) for pharmacokinetic and non-invasive imaging studies J. Pharmacol. Exp. Ther. 308 2004 419 425
6. N. Bertrand, and J.C. Leroux The journey of a drug-carrier in the body: an anatomo-physiological perspective J. Control. Release 161 2012 152 163
7. J.R. Bogner, U. Kronawitter, B. Rolinski, K. Truebenbach, and F.D. Goebel Liposomal doxorubicin in the treatment of advanced AIDS-related Kaposi sarcoma J. Acquir. Immune Defic. Syndr. 7 1994 463 468
8. L. Brannon-Peppas, and J.O. Blanchette Nanoparticle and targeted systems for cancer therapy Adv. Drug Deliv. Rev. 56 2004 1649 1659
9. S. Breyer, A. Semmler, T. Miller, A. Hill, S. Geissler, U. Haberkorn, and W. Mier Radioiodinated dechloro-4-iodofenofibrate: a hydrophobic model drug for molecular imaging studies Int. J. Pharm. 431 2012 78 83
10. H.M. Burt, X.C. Zhang, P. Toleikis, L. Embree, and W.L. Hunter Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel Colloids Surf. B: Biointerfaces 16 1999 161 171
11. H. Chen, S. Kim, W. He, H. Wang, P.S. Low, K. Park, and J.X. Cheng Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imaging Langmuir 24 2008 5213 5217
12. W.H. De Jong, and P.J. Borm Drug delivery and nanoparticles:applications and hazards Int. J. Nanomedicine 3 2008 133 149
13. G. Gaucher, M.H. Dufresne, V.P. Sant, N. Kang, D. Maysinger, and J.C. Leroux Block copolymer micelles: preparation, characterization and application in drug delivery J. Control. Release 109 2005 169 188
14. G. Gaucher, R.H. Marchessault, and J.C. Leroux Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes J. Control. Release 143 2010 2 12
15. F.D. Goebel, D. Goldstein, M. Goos, H. Jablonowski, and J.S. Stewart Efficacy and safety of Stealth liposomal doxorubicin in AIDS-related Kaposi's sarcoma. The International SL-DOX Study Group Br. J. Cancer 73 1996 989 994
16. A. Helbok, C. Rangger, G.E. von, M. Saba-Lepek, T. Radolf, G. Thurner, F. Andreae, R. Prassl, and C. Decristoforo Targeting properties of peptide-modified radiolabeled liposomal nanoparticles Nanomedicine 8 2012 112 118
17. C. Heneweer, J.P. Holland, V. Divilov, S. Carlin, and J.S. Lewis Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system J. Nucl. Med. 52 2011 625 633
18. B. Hoang, H. Lee, R.M. Reilly, and C. Allen Noninvasive monitoring of the fate of 111In-labeled block copolymer micelles by high resolution and high sensitivity microSPECT/CT imaging Mol. Pharm. 6 2009 581 592
19. N.D. James, R.J. Coker, D. Tomlinson, J.R. Harris, M. Gompels, A.J. Pinching, and J.S. Stewart Liposomal doxorubicin (Doxil): an effective new treatment for Kaposi's sarcoma in AIDS Clin. Oncol. (R. Coll. Radiol.) 6 1994 294 296
20. S.C. Kim, D.W. Kim, Y.H. Shim, J.S. Bang, H.S. Oh, K.S. Wan, and M.H. Seo In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy J. Control. Release 72 2001 191 202
21. H. Lee, B. Hoang, H. Fonge, R.M. Reilly, and C. Allen In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels Pharm. Res. 27 2010 2343 2355
22. S.W. Lee, M.H. Yun, S.W. Jeong, C.H. In, J.Y. Kim, M.H. Seo, C.M. Pai, and S.O. Kim Development of docetaxel-loaded intravenous formulation, Nanoxel-PM (TM) using polymer-based delivery system J. Control. Release 155 2011 262 271
23. K. Letchford, and H.M. Burt Copolymer micelles and nanospheres with different in vitro stability demonstrate similar Paclitaxel pharmacokinetics Mol. Pharm. 9 2012 248 260
24. W.T. Lim, E.H. Tan, C.K. Toh, S.W. Hee, S.S. Leong, P.C. Ang, N.S. Wong, and B. Chowbay Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol-PM) in patients with solid tumors Ann. Oncol. 21 2010 382 388
25. A. Liu, A.D. Patterson, Z. Yang, X. Zhang, W. Liu, F. Qiu, H. Sun, K.W. Krausz, J.R. Idle, F.J. Gonzalez, and R. Dai Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics Drug Metab. Dispos. 37 2009 1157 1163
26. J. Lu, S.C. Owen, and M.S. Shoichet Stability of self-assembled polymeric micelles in serum Macromolecules (Washington, DC, USA) 44 2011 6002 6008
27. W. Mier, J. Hoffend, S. Kramer, J. Schuhmacher, W.E. Hull, M. Eisenhut, and U. Haberkorn Conjugation of DOTA using isolated phenolic active esters: the labeling and biodistribution of albumin as blood pool marker Bioconjug. Chem. 16 2005 237 240
28. T. Miller, A. Hill, S. Uezguen, M. Weigandt, and A. Goepferich Analysis of immediate stress mechanisms upon injection of polymeric micelles and related colloidal drug carriers: implications on drug targeting Biomacromolecules 13 2012 1707 1718
29. T. Miller, R. Rachel, A. Besheer, S. Uezguen, M. Weigandt, and A. Goepferich Comparative investigations on in vitro serum stability of polymeric micelle formulations Pharm. Res. 29 2012 448 459
30. Miller, T.; van Colen, G.; Sander, B.; Golas, M.M.; Uezguen, S.; Weigandt, M.; Goepferich, A. Drug loading of polymeric micelles. Pharm. Res.; in press.
31. S.M. Moghimi, and J. Szebeni Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties Prog. Lipid Res. 30 2 2013 584 595
32. J. Najib Fenofibrate in the treatment of dyslipidemia: a review of the data as they relate to the new suprabioavailable tablet formulation Clin. Ther. 24 2002 2022 2050
33. D.E. Owens, and N.A. Peppas Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int. J. Pharm. 307 2006 93 102
34. K.F. Pirollo, and E.H. Chang Does a targeting ligand influence nanoparticle tumor localization or uptake? Trends Biotechnol. 26 2008 552 558
35. R. Plummer, R.H. Wilson, H. Calvert, A.V. Boddy, M. Griffin, J. Sludden, M.J. Tilby, M. Eatock, D.G. Pearson, C.J. Ottley, Y. Matsumura, K. Kataoka, and T. Nishiya A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours Br. J. Cancer 104 2011 593 598
36. P. Poulin, K. Schoenlein, and F.P. Theil Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs J. Pharm. Sci. 90 2001 436 447
37. P. Poulin, and F.P. Theil A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery J. Pharm. Sci. 89 2000 16 35
38. B. Rosenberg, L. Van Camp, and T. Krigas Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode Nature 205 1965 698 699
39. P.P. Surujpaul, C. Gutierrez-Wing, B. Ocampo-Garcia, F.M. Ramirez, M.C. rteaga de, M. Pedraza-Lopez, M.A. Camacho-Lopez, and G. Ferro-Flores Gold nanoparticles conjugated to [Tyr3]octreotide peptide Biophys. Chem. 138 2008 83 90
40. J.K. Tessmar, A.G. Mikos, and A. Gopferich Amine-reactive biodegradable diblock copolymers Biomacromolecules 3 2002 194 200
41. J.A. Thie Nuclear Medicine Imaging: An Encyclopedic Dictionary 2012 Springer Berlin, Heidelberg
42. V.P. Torchilin Micellar nanocarriers: pharmaceutical perspectives Pharm. Res. 24 2007 1 16
43. P. Utreja, S. Jain, S. Yadav, K.L. Khandhuja, and A.K. Tiwary Efficacy and toxicological studies of cremophor el free alternative Paclitaxel formulation Curr. Drug Saf. 6 2011 329 338
44. J.K. Vasir, and V. Labhasetwar Targeted drug delivery in cancer therapy Technol. Cancer Res. Treat. 4 2005 363 374
45. A. Weil, J. Caldwell, and M. Strolin-Benedetti The metabolism and disposition of fenofibrate in rat, guinea pig, and dog Drug Metab. Dispos. 16 1988 302 309
46. N. Wiradharma, Y. Zhang, S. Venkataraman, J.L. Hedrick, and Y.Y. Yang Self-assembled polymer nanostructures for delivery of anticancer therapeutics Nano Today 4 2009 302 317
47. X.Y. Xu, X.F. Zhang, X.H. Wang, Y.X. Li, and X.B. Jing Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA Polym. Adv. Technol. 20 2009 843 848
48. F. Yuan, M. Dellian, D. Fukumura, M. Leunig, D.A. Berk, V.P. Torchilin, and R.K. Jain Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size Cancer Res. 55 1995 3752 3756