Radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI agents

Current Topics in Medicinal Chemistry

Volumn 12, Issue 23, 2012, Pages 2694-2702

  Bouziotis, Penelope ^a   Psimadas, Dimitrios ^b   Tsotakos, Theodoros ^a   Stamopoulos, Dimosthenis ^a   Tsoukalas, Charalampos ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b UNIVERSITY HOSPITAL OF LARISSA   (Greece)

Author keywords

Dual modality imaging; Iron oxide; Magnetic nanoparticles; PET MRI; Radiolabeling; SPECT MRI

Indexed keywords

CONTRAST MEDIUM; IRON OXIDE; NANOPARTICLE; TRACER;

ACTIVE TARGETING; CANCER RADIOTHERAPY; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST ACCURACY STUDY; DRUG TARGETING; HUMAN; ISOTOPE LABELING; MOLECULAR IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PASSIVE TARGETING; POSITRON EMISSION TOMOGRAPHY; REVIEW; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SURFACE PROPERTY;

ANTIBODIES; ANTINEOPLASTIC AGENTS; CONTRAST MEDIA; FERRIC COMPOUNDS; HUMANS; ISOTOPE LABELING; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; NEOPLASMS; PEPTIDES; POSITRON-EMISSION TOMOGRAPHY; RADIOISOTOPES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84874910436     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026611212230007     Document Type: Review

References (76)

1. Cancer facts and figures 2011, American Cancer Society 2011.
2. Hamamura, M.J.; Ha, S.; Roeck, W.W.; Muftuler, L.T.; Wagenaar, D.J.; Meier, D., et al. Development of an MR-compatible SPECT system (MRSPECT) for simultaneous data acquisition. Phys. Med. Biol., 2010, 55, 1563-1575.
3. Catana, C.; Wu, Y.B.; Judenhofer, M.S et al. Simultaneous acquisition of multislice PET and MRI images: Initial results with a MR-compatible PET scanner. J. Nucl. Med., 2006, 47, 1968-1976.
4. Goetz, C.; Breton, E.; Choquet, P.; Israel-Jost V., Constantinesco A. A SPECT low-field MRI system for small-animal imaging. J. Nucl. Med., 2008, 49, 88-93.
5. Catana, C.; Procissi, D.; Wu, Y.; Judenhofer, M.S.; Qi, J.; Pichler, B.J., et al. Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc. Natl. Acad. Sci. USA, 2008, 105, 3705-3710.
6. Huber, M.M.; Staubli, A.B.; Kustedjo K., et al. Fluorescently detectable magnetic resonance imaging agents, Bioconjugate Chem., 1998, 9, 242-249.
7. Schellenberger, E.A.; Sosnovik, D.; Weissleder, R. et al. Magneto/optical annexin V, a multimodal protein, Bioconjugate Chem., 2004, 15, 1062-1067.
8. Wang, W.; Ke, S.; Kwon, S., et al. A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain. Bioconjugate Chem., 2007, 18, 397-402.
9. Lee, S.K.; and Chen, X., Dual-modality probes for in vivo molecular imaging. Mol. Imaging, 2009, 8, 87-100.
10. Lee, H.Y.; Li, Z.; Chen, K., et al. PET/MRI dual-modality tumor imaging using Arginine-Glycine-Aspartic (RGD)-conjugated radio-labeled iron oxide nanoparticles. J. Nucl. Med., 2008, 49, 1371-1379.
11. Xie, J.; Huang, J.; Li, X., et al. Iron oxide nanoparticle platform for biomedical applications. Curr. Med. Chem., 2009, 16, 1278-1294.
12. Shokeen, M.; Fettig, N.M.; and Rossin, R., Synthesis, in vitro and in vivo evaluation of radiolabeled nanoparticles. Q. J. Nucl. Med. Mol. Imaging, 2008, 52, 267-277.
13. Frey, N.A.; Peng, S.; Cheng, K.; Sun, S., Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storage. Chem. Soc. Rev., 2009; 38: 2532-2542.
14. Ho, D., Sun, X., Sun, S. Monodisperse magnetic nanoparticles for theranostic applications. Acc. Chem. Res., 2011, 44, 875-882.
15. Mahmoudi, M.; Sant, S.; Wang, B.; Laurent, S.; Sen, T. Superpar-amagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. Adv. Drug Deliv. Rev., 2011, 63, 24-46.
16. Gupta, A.K.; Gupta, M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials, 2005, 26, 3995-4021.
17. Qiao, R.; Yang, C.; Gao, M. Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications. J. Mater Chem., 2009, 19, 6274-6293.
18. Sugimoto, T.; Matijevic, E. Formation of uniform spherical magnetite particles by crystallization from ferrous hydroxide gels. J. Colloid Interface Sci., 1980, 74, 227-243.
19. Massart, R. Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Trans Magn., 1981, 17, 1247-1248.
20. Kim, D.K.; Zhang, Y.; Voit, W.; Rao, K.V.; Muhammed, M. Synthesis and characterization of surfactant-coated superparamagnetic monodispersed iron oxide nanoparticles. J. Magn. Magn. Mater, 2001, 225: 30-36.
21. Maity, D.; Choo, S.G.; Yi, J.B.; Ding, J.; Xue, J.M., Synthesis of magnetite nanoparticles via a solvent-free thermal decomposition route. J. Magn Magn Materials, 2009, 321, 1256-1259.
22. Kishore, P.N.R.; Jeevanandam, P., A novel thermal decomposition approach for the synthesis of silica-iron oxide core-shell nanoparticles. J. Alloys Comp., 2012, 522, 51-62.
23. Lopez-Quintela, M.A. Synthesis of nanomaterials in microemulsions: formation mechanisms and growth control. Cur Opinion Colloid Interface Sci., 2003, 8, 137-144.
24. Dang, F.; Enomoto, N.; Hojo, J.; Enpuku, K.; A novel method to synthesize monodispersed magnetite nanoparticles. Chem. Lett., 2008, 37, 530-531.
25. Hu, L.; Percheron, A.; Chaumont, D.; Bracahis, C-H., Microwave-assisted one-step hydrothermal synthesis of pure iron-oxide nanoparticles: Magnetite, maghemite and hematite. J. Sol-Gel Sci. Tech., 2011, 60, 198-205.
26. Berry, C.C.; and Curtis A.S.G., Functionalisation of magnetic nanoparticles for applications in biomedicine, J. Phys. D: Appl. Phys., 2003, 36, R198-R206.
27. Neuberger, T.; Schopf, B.; Hofmann, H.; Hofmann, M., von Re-chenberg, B. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J. Magn Magn Mater, 2005, 293, 483-496.
28. Choi, H.S.; Liu, W.; Mirsa, P.; Tanaka, E.; Zimmer, J.P.; Ipe, B.I.; Bawendi, M.G.; Frangioni J.V., Renal clearance of quantum dots. Nat. Biotechnol., 2007, 25, 1165-1170.
29. Tong, L., Zhao, M., Zhu, S., Chen, J. Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer. Front Med 2011; 5: 379-387.
30. Hong, R.Y., Li, J.H., Qu, J.M., Chen, L.L., Li, H.Z. Preparation and characterization of magnetite/dextran nanocomposite used as a precursor of magnetic fluid. Chem Eng J 2009; 150: 572-580.
31. Griffiths S.M., Singh N., Jenkins G.J., Williams P.M., Orbaek A.W., Barron A.R., Wright C.J., Doak S.H., Dextran-coated ul-trafine superparamagentic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes, Anal Chem 2011; 83(10): 3778-3785.
32. Babic M., Horak D., Trchova M., Jendelova P., Glogarova K., Lesny P., Herynek V., Hajek M., Sykova E., Poly(L-lysine)-modified iron oxide nanoparticles for stem cell labeling, Bioconjug Chem 2008; 19(3): 740-750.
33. Maeng J.H., Lee D.H., Jung K.H., Bae Y.H., Park I.S., Jeong S., Jeon Y.S., Shim C.K., Kim W., Kim J., Lee J., Lee Y.M., Kim J.H., Kim W.H., Hong S.S., Multifunctional doxorubicin loaded super-paramagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer, Biomaterials 2010; 31(18): 4995-5006.
34. Liao, Z.; Wang, H.; Lv, R.; Zhao, P.; Sun, X.; Wang, S.; Su, W.; Niu, R.; Chang, J., Polymeric liposomes-coated superparamagnetic iron oxide nanoparticles as contrast agent for targeted magnetic resonance imaging of cancer cells. Langmuir, 2011, 27(6), 3100-3105.
35. Mikhaylova, M.; Kim, D.K.; Bobrysheva, N.; Osmolowsky, M.; Semenov, V.; Tsakalakos, T.; Muhammed, M., Superparamagnetism of magnetite nanoparticles: dependence on surface modification. Langmuir, 2004, 20, 2472-2477.
36. nd Edn
37. Huh, Y-M et al, In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J. Am. Chem. Soc, 2005, 127, 12387-12391.
38. P. Bouziotis. et al, Eur. J. Nucl. Med. Mol. Imaging, 2009, 36 (Suppl2): S250.
39. Molday, R.S.; and Mackenzie D., J. Immunol. Methods, 1982, 52, 353
40. Wunderbaldinger, P.; Josephson, L.; and Weissleder R., Bioconjugate Chem., 2002, 13, 264.
41. Maeda, H.; The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecu-lar drug targeting. Advan.Enzyme Regul, Vol. 41, pp 189-207, 2001.
42. Maeda H., Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug Chem., 2010, 21, 797-802.
43. I. Brigger; C. Dubernet; P. Couvreur., Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev., 2002, 54, 631-651.
44. Laurent, S.; Forge, D.; Port, M.; Roch, A.; Robic, C; Elst, L.V.; Muller, R.N., Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterization and biological applications. Chem. Rev., 2008; 108: 2064-2110.
45. Gupta A.K., Naregalkar R.R., Vaidya V.D., Gupta M, Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomedicine, 2007, 2, 23-39.
46. Liu, S.; Jia, B.; Qiao, R.; Yang, Z.; Yu, Z.; Liu, Z., et al, A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: preparation, characterization and in vivo application. Mol. Pharm., 2009, 14, 253-260.
47. Montet, X.K.; Montet-Abou, F.; Reynolds, R.; Weissleder, Nanoparticle imaging of integrins on tumor cells. Neoplasia, 2006, 8, 214-222.
48. Veiseh, O., et al, Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv. Drug. Deliv. Rev., 2010, 62, 284-304.
49. McCarthy, J.R.; and Weissleder, R., Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv. Drug Deliv. Rev., 2008, 60, 1241-1251.
50. Xu, C, and Sun, S., Superparamagnetic nanoparticles as targeted probes for diagnostic and therapeutic applications. Dalton Trans, 2009, 29, 5583-5591.
51. Brennan, F.R. et al, Mol. Biotechnol., 2004, 27, 59.
52. Weinberg, W.C., et al, Cancer Metast. Rev., 2005, 24, 569.
53. Winter, P.M.; Morawski, A.M.; Caruthers, S.D., et al. Molecular imaging of angiogenesis in early-stage atherosclerosis with al-pha(v)beta3-integrin-targeted nanoparticles. Circulation, 2003, 108, 2270-2274.
54. Anderson, S.A.; Rader, R.K.; Westlin, W.F. et al, Magnetic resonance contrast enhancement of neovasculature with al-pha(v)beta(3)-targeted nanoparticles. Magn Reson Med., 2000, 44, 433-439.
55. Schmieder, A.H.; Winter, P.M.; Caruthers, S.D. et al, Molecular MR imaging of melanoma angiogenesis with alpha(nu)beta(3)-targeted paramagnetic nanoparticles. Magn Reson. Med., 2005, 53, 621-627.
56. Liu, Y.; and Welch M.J., Nanoparticles labeled with positron emitting nuclides: advantages, methods and applications. Bioconjugate Chem., 2012, 23, 671-682
57. Mody, V.V., Nanoparticles in Nuclear Imaging. Internet Journal of Medical Update, 2011, 6(1): 24-30.
58. 99mTc-Labeled Superparamagnetic Iron Oxide Nanoparticles for Multimodality SPECT/MRI of Sentinel Lymph Nodes. J. Nucl. Med., 2012, 53, 459-463.
59. 99mTc-Bisphosphonate-Iron Oxide Nanoparticle Conjugates for Dual-Modality Biomedical Imaging. Bioconjugate Chem., 2011, 22, 455-465.
60. Psimadas, D.; Baldi, G.; Ravagli, C; Bouziotis, P.; Xanthopoulos, S.; Franchini, M.C.; Georgoulias, P.; and Loudos, G., Preliminary Evaluation of a 99mTc Labeled Hybrid Nanoparticle Bearing a Cobalt Ferrite Core: In Vivo Biodistribution. Journal of Biomedical Nanotechnology, 2012, 8, 575-585.
61. Choi, J.; Park, J.C.; Nah, H.; Woo, S.; Oh, J.; Kim, K.M.; Cheon G.J.; Chang, Y.; Yoo, J.; and Cheon, J., A Hybrid Nanoparticle Probe for Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging. Angew Chem. Int. Ed., 2008, 47, 6259-6262.
62. Nahrendorf, M.; Zhang, H.; Hembrador, S.; Panizzi, P.; Sosnovik, D.E.; Aikawa, E.; Libby, P.; Swirski, P.K.; Weissleder, R., Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis. Circulation, 2008, 117, 379-387.
63. 64Cu-Labeled Magnetic Nanoparticles for Multimodal Imaging. Bioconjugate Chemistry, 2008, 19(7): 1496-1504.
64. 18F Labeled Nanoparticles for in ViWo PET-CT Imaging Bioconjugate Chemistry, 2009, 20, 397-401.
65. Morales-Avila, E.; Ferro-Flores, G.; Ocampo-García, B.E., and de María Ramírez F., Radiolabeled Nanoparticles for Molecular Imaging Molecular Imaging. Eds. Intech., 2012.
66. Stelter, L.; Pinkernelle, J.G.; Michel, R.; Schwartländer, R.; Ra-schzok, N.; Morgul, M.H.; Koch, M.; Denecke, T.; Ruf, J.; Bäum-ler, H.; Jordan, A.; Hamm, B.; Sauer, I.M.; Teichgräber, U., Modification of Aminosilanized Superparamagnetic Nanoparticles: Feasibility of Multimodal Detection Using 3T MRI, Small Animal PET, and Fluorescence Imaging. Molecular Imaging and Biology, 2010, 12, 25-34.
67. Glaus, C.; Rossin, R.; Welch, M.J.; and Bao, G., In vivo evaluation of 64Cu-labeled Magnetic Nanoparticles as a Dual-Modality PET/MR Imaging Agent. Bioconjugate Chemistry, 2010, 21(4), 715-722.
68. Xie, J.; Chen, K.; Huang, J.; Lee, S.; Wang, J.; Gao, J.; Li, X.; Chen, X. PET/NIRF/MRI triple functional iron oxide nanoparticles Biomaterials, 2010, 31, 3016-3022.
69. II-Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET-MRI Agent Angewandte, 2011; 50, 5509-5513.
70. 64Cu-Doped Iron Oxide Nanoparticles ACSNANO, 2012, 6(4), 3461-3467.
71. Cerdan, S.; Lotscher, H.R.; Kunnecke, B.; and Seelig, J., Magn Reson Med., 1989, 12, 151.
72. Almutairi A.; Rossin, R.; Shokeen, M.; et al. "Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis". PNAS, 2009, 106, 685-690.
73. Misri, R.; Meier, D.; Yung, A.C.; Kozlowski, P.; Häfeli, U.O., Development and evaluation of a dual-modality (MRI/SPECT) molecular imaging bioprobe, Nanomedicine: Nanotechnology. Biology, and Medicine, 2012, 8, 1007-1016.
74. Lee, H.Y.; Li, Z.; Chen, K.; Hsu, A.R.; Xu, C.; Xie, J.; Sun, S.; and Chen X., PET/MRI Dual-Modality Tumor Imaging Using Argin-ine-Glycine-Aspartic (RGD)-Conjugated Radiolabeled Iron Oxide Nanoparticles. J. Nucl. Med., 2008, 49, 1371-1379.
75. 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials, 2011, 32, 4151-4160.
76. Lee, S.C.M.; Jeong, H-J.; Kim, E-M.; Kim, D.W.; Lim, S.T.; Kim, H.T.; Park, I-K.; Jeong, Y.Y.; Kim, J.W.; and Sohn, M-H., Super-paramagnetic Iron Oxide Nanoparticles as a Dual Imaging Probe for Targeting Hepatocytes In Vivo. Magnetic Resonance in Medicine, 2009, 62, 1440-1446.