Preliminary evaluation of a 99mTc labeled hybrid nanoparticle bearing a cobalt ferrite core: In vivo biodistribution

Journal of Biomedical Nanotechnology

Volumn 8, Issue 4, 2012, Pages 575-585

  Psimadas, Dimitrios ^a,c,e   Baldi, Giovanni ^b   Ravagli, Costanza ^b   Bouziotis, Penelope ^c   Xanthopoulos, Stavros ^c   Franchini, Mauro Comes ^d   Georgoulias, Panagiotis ^a   Loudos, George ^e  

^a UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^b CERICOL   (Italy)

^c INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e UNIVERSITY OF WEST ATTICA   (Greece)

Author keywords

Cobalt ferrite; Imaging; Nanoparticles; Radiolabeling; SPECT; Technetium

Indexed keywords

BIODISTRIBUTIONS; BOVINE SERUM ALBUMINS; COBALT FERRITES; HIGH YIELD; HYBRID NANOPARTICLE; IN-VITRO; IN-VIVO; LOW FREQUENCY; MAGNETIC NANOPARTICLES; MONODISPERSE; POLY LACTIC-CO-GLYCOLIC ACID; RADIOLABELING; SPECT; SPECT IMAGING;

DRUG DELIVERY; FERRITE DEVICES; IMAGING TECHNIQUES; IRON OXIDES; MAGNETIC CORES; MAMMALS; TECHNETIUM;

NANOPARTICLES;

12 (HYDROXYAMINO) 12 OXODODECANOATE; BOVINE SERUM ALBUMIN; COBALT; DECANOIC ACID DERIVATIVE; FERRITE; NANOPARTICLE; POLYGLACTIN; TECHNETIUM 99M; TIN CHLORIDE; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; FERRIC ION; METAL NANOPARTICLE; PERTECHNETIC ACID TC 99M; RADIOPHARMACEUTICAL AGENT; TECHNETIUM DERIVATIVE;

ARTICLE; EVALUATION; HYPERTHERMIA; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIVER; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPLEEN; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; FEMALE; IMAGE ENHANCEMENT; METHODOLOGY; MOUSE; PARTICLE SIZE; TISSUE DISTRIBUTION; ULTRASTRUCTURE;

ANIMALS; COBALT; DRUG DELIVERY SYSTEMS; FEMALE; FERRIC COMPOUNDS; IMAGE ENHANCEMENT; ISOTOPE LABELING; METAL NANOPARTICLES; MICE; PARTICLE SIZE; RADIOPHARMACEUTICALS; SODIUM PERTECHNETATE TC 99M; TECHNETIUM COMPOUNDS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84865148680     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2012.1412     Document Type: Article

References (44)

1. P. H. Hoet, I. Brüske-Hohlfeld, and O. V. Salata, Nanoparticles - known and unknown health risks. J. Nanobiotechnol. 2, 12 (2004).
2. T. D. Schladt, K. Schneider, H. Schild, and W. Tremel, Synthesis and bio-functionalization of magnetic nanoparticles for medical diagnosis and treatment. Dalton Trans. 40, 6315 (2011).
3. C. S. Kumar and F. Mohammad, Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv. Drug Deliv. Rev. 63, 789 (2011).
4. M. Hamoudeh, M. A. Kamleh, R. Diab, and H. Fessi, Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer. Adv. Drug Deliv. Rev. 60, 1329 (2008).
5. M. Tang, P. J. Russell, and A. Khatri, Magnetic nanoparticles: Prospects in cancer imaging and therapy. Discov. Med. 38, 68 (2007).
6. S. K. Libutti, G. F. Paciotti, A. A. Byrnes, H. R. Alexander, Jr., W. E. Gannon, M. Walker, G. D. Seidel, N. Yuldasheva, and L. Tamarkin, Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Clin. Cancer Res. 16, 6139 (2010).
7. T. Islam and M. G. Harisinghani, Overview of nanoparticle use in cancer imaging. Cancer Biomark. 5, 61 (2009).
8. H. Hong, Y. Zhang, J. Sun, and W. Cai, Molecular imaging and therapy of cancer with radiolabeled nanoparticles. Nano Today 4, 399 (2009).
9. J. R. McCarthy and R. Weissleder, Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv. Drug Deliv. 60, 1241 (2008).
10. Y. Zhao, J. L. Vivero-Escoto, I. I. Slowing, B. G. Trewyn, and V. S. Lin, Capped mesoporous silica nanoparticles as stimuliresponsive controlled release systems for intracellular drug/gene delivery. Expert Opin. Drug Deliv. 7, 1013 (2010).
11. V. V. Mody, R. Siwale, A. Singh, and H. R. Mody, Introduction to metallic nanoparticles. J. Pharm. Bioallied. Sci. 2, 282 (2010).
12. B. D. de Senneville, C. Mougenot, B. Quesson, I. Dragonu, N. Grenier, and C. T. Moonen, MR thermometry for monitoring tumor ablation. Eur. Radiol. 17, 2401 (2007).
13. I. Brigger, C. Dubernet, and P. Couvreur, Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev. 54, 631 (2002).
14. J.-P. Fortin, C. Wilhelm, J. Servais, C. Menager, J. C. Bacri, and F. Gazeau, Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J. Am. Chem. Soc. 129, 2628 (2007).
15. 99mTc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. Bioconjug. Chem. 16, 455 (2011).
16. H. Y. Lee, Z. Li, K. Chen, A. R. Hsu, C. Xu, J. Xie, S. Sun, and X. Chen, PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J. Nucl. Med. 49, 1371 (2008).
17. 99mTc-labeled liposome encapsulated cyclosporine, J. Drug Target. 11, 187 (2003).
18. L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. R. Murthy, Etoposide-incorporated tripalmitin nanoparticles with different surface charge: formulation, characterization, radiolabeling, and biodistribution studies. AAPS J. 7, e23 (2004).
19. M. Snehalatha, K. Venugopal, R. N. Saha, A. K. Babbar, and R. K. Sharm, Etoposide loaded PLGA and PCL nanoparticles II: Biodistribution and pharmacokinetics after radiolabeling with Tc-99m. Drug Deliv. 15, 277 (2008).
20. E. Morales-Avila, G. Ferro-Flores, B. E. Ocampo-García, L. M. De León-Rodríguez, C. L. Santos-Cuevas, R. García-Becerra, L. A. Medina, and L. Gómez-Oliván, Multimeric system of (99m)Tc-labeled gold nanoparticles conjugated to c[RGDfK(C)] for molecular imaging of tumor α(v)β(3) expression. Bioconjug. Chem. 18, 913 (2011).
21. S. Kommareddy and M. Amiji, Biodistribution and pharmacokinetic analysis of long-circulating thiolated gelatin nanoparticles following systemic administration in breast cancer-bearing mice. J. Pharm. Sci. 96, 397 (2007).
22. A. Chrastina and J. E. Schnitzer, Iodine-125 radiolabeling of silver nanoparticles for in vivo SPECT imaging. Int. J. Nanomedicine 7, 653 (2010).
23. M. Shokeen, N. M. Fettig, and R. Rossin, Synthesis, in vitro and in vivo evaluation of radiolabeled nanoparticles. Q. J. Nucl. Med. Mol. Imaging 52, 267 (2008).
24. J. Cao, Y. Wang, J. Yu, J. Xia, C. Zhang, D. Yin, and U. O. Häfeli, Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy. J. Magn. Magn. Mat. 277, 165 (2004).
25. W. D. Hwang, H. Y. Ko, J. H. Lee, H. Kang, S. H. Ryu, I. C. Song, D. S. Lee, and S. Kim, A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer. J. Nucl Med. 51, 98 (2010).
26. R. Rossin, S. Muro, M. J. Welch, V. R. Muzykantov, and D. P. Schuster, In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium. J. Nucl. Med. 49, 103 (2008).
27. C. Glaus, R. Rossin, M. J. Welch, and G. Bao, In vivo evaluation of (64)Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent. Bioconjug. Chem. 21, 715 (2010).
28. J. Xie, K. Chen, J. Huang, S. Lee, J. Wang, J. Gao, X. Li, and X. Chen, PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 31, 3016 (2010).
29. G. Baldi, D. Bonacchi, C. Innocenti, G. Lorenzi, and C. Sangregorio, Cobalt ferrite nanoparticles: The control of the particle size and surface state and their effects on magnetic properties. J. Magn. Magn. Mat. 311, 10 (2007).
30. G. Baldi, D. Bonacchi, M. C. Franchini, D. Gentili, G. Lorenzi, A. Ricci, and C. Ravagli, Synthesis and coating of cobalt ferrite nanoparticles: A first step toward the obtainment of new magnetic nanocarriers. Langmuir 23, 4026 (2007).
31. J. Kim, J.-E. Lee, S. Hyeon Lee, J.-H. Yu, J.-H. Lee, T. G. Park, and T. Hyeon, Designed Fabrication of a multifunctional polymer nanomedical platform for simultaneous cancer-targeted imaging and magnetically guided drug delivery. Adv. Mater. 20, 478 (2008).
32. M. Comes Franchini, G. Baldi, D. Bonacchi, D. Gentili, G. Giudetti, A. Lascialfari, M. Corti, P. Marmorato, J. Ponti, E. Micotti, U. Guerrini, L. Sironi, P. Gelosa, C. Ravagli, and A. Ricci, Bovine serum albumin-based magnetic nanocarrier for MRI diagnosis and hyperthermic therapy: A potential theranostic approach against cancer. Small 5, 366 (2010).
33. N. Shamim, L. Hong, K. Hidajat, and M. S. Uddin, Thermosensitive-polymer- coated magnetic nanoparticles: Adsorption and desorption of bovine serum albumin. J. Colloid. Interface Sci. 304, 1 (2006).
34. T. Banerjee, A. K. Singh, R. K. Sharma, and A. N. Maitra, Labeling efficiency and biodistribution of Technetium-99m labeled nanoparticles: Interference by colloidal tin oxide particles. Int. J. Pharm. 289, 189 (2005).
35. G. Loudos, P. Papadimitroulas, P. Zotos, I. Tsougos, and P. Georgoulias, Development and evaluation of QSPECT open-source software for the iterative reconstruction of SPECT images. Nuclear Medicine Communications 31, 558 (2010).
36. Y. W. Cho, S. A. Park, T. H. Han, D. H. Son, J. S. Park, S. J. Oh, D. H. Moon, K. J. Cho, C. H. Ahn, Y. Byun, I. S. Kim, I. C. Kwon, and S. Y. Kim, In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles: Mechanisms, key factors, and their implications. Biomaterials 28, 1236 (2007).
37. A. Szasz and G. Vincze, Dose concept of oncological hyperthermia: Heat-equation considering the cell destruction. J. Cancer Res. Ther. 2, 171 (2006).
38. 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials 32, 4151 (2011).
39. K. K. Halder, B. Mandal, M. C. Debnath, H. Bera, L. K. Ghosh, and B. K. Gupta, Chloramphenicol-incorporated poly lactide-co-glycolide (PLGA) nanoparticles: formulation, characterization, technetium-99m labeling and biodistribution studies. J. Drug Target. 16, 311 (2008).
40. S. Liu, B. Jia, R. Qiao, Z. Yang, Z. Yu, Z. Liu, K. Liu, J. Shi, H. Ouyang, F. Wang, and M. Gao, A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: Preparation, characterization and in vivo application. Mol. Pharm. 6, 1074 (2009).
41. S. Stolnik, C. R. Heald, J. Neal, M. C. Garnett, S. S. Davis, L. Illum, S. C. Purkis, R. J. Barlow, P. R. Gellert. Polylactide-poly(ethylene glycol) micellar-like particles as potential drug carriers: Production, colloidal properties and biological performance. J. Drug Target. 9, 361 (2001).
42. J. Wang, Y. Chen, B. Chen, J. Ding, G. Xia, C. Gao, J. Cheng, N. Jin, Y. Zhou, X. Li, M. Tang, and X. M. Wang, Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice. Int. J. Nanomedicine 5, 861 (2010).
43. A. Chanan-Khan, S. Srinivasan, and M. S. Czuczman, Prevention and management of cardiotoxicity from antineoplastic therapy. J. Support. Oncol. 2, 259 (2004).
44. E. Sadauskas, H. Wallin, M. Stoltenberg, U. Vogel, P. Doering, A. Larsen, and G. Danscher, Kupffer cells are central in the removal of nanoparticles from the organism. Part. Fibre. Toxicol. 4, 1 (2007).