메뉴 건너뛰기




Volumn 14, Issue 2, 2013, Pages 100-113

The AKT1 gene is associated with attention and brain morphology in schizophrenia

Author keywords

AKT1; Attention; Schizophrenia; Single nucleotide polymorphism (SNP); VBM

Indexed keywords

PROTEIN KINASE B;

EID: 84874899656     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2011.591826     Document Type: Article
Times cited : (23)

References (64)
  • 1
    • 0022930826 scopus 로고
    • Parallel organization of functionally segregated circuits linking basal ganglia and cortex
    • Alexander GE, DeLong MR, Strick PL. 1986. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9: 357-381. (Pubitemid 16055790)
    • (1986) Annual Review of Neuroscience , vol.VOL. 9 , pp. 357-381
    • Alexander, G.E.1    DeLong, M.R.2    Strick, P.L.3
  • 2
    • 0033933649 scopus 로고    scopus 로고
    • Voxel-based morphometry-the methods
    • Ashburner J, and Friston KJ. 2000. Voxel-based morphometry-the methods. Neuroimage 11: 805-821.
    • (2000) Neuroimage , vol.11 , pp. 805-821
    • Ashburner, J.1    Friston, K.J.2
  • 6
    • 22744449073 scopus 로고    scopus 로고
    • An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    • DOI 10.1016/j.cell.2005.05.012, PII S0092867405004575
    • Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. 2005. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-273. (Pubitemid 41032989)
    • (2005) Cell , vol.122 , Issue.2 , pp. 261-273
    • Beaulieu, J.-M.1    Sotnikova, T.D.2    Marion, S.3    Lefkowitz, R.J.4    Gainetdinov, R.R.5    Caron, M.G.6
  • 7
    • 33947583891 scopus 로고    scopus 로고
    • The Akt-GSK-3 signaling cascade in the actions of dopamine
    • DOI 10.1016/j.tips.2007.02.006, PII S0165614707000533
    • Beaulieu JM, Gainetdinov RR, Caron MG. 2007a. The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends Pharmacol Sci 28: 166-172. (Pubitemid 46483722)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.4 , pp. 166-172
    • Beaulieu, J.-M.1    Gainetdinov, R.R.2    Caron, M.G.3
  • 9
    • 60749112924 scopus 로고    scopus 로고
    • Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
    • Betcheva ET, Mushiroda T, Takahashi A, Kubo M, Karachanak SK, Zaharieva IT, et al. 2009. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet 54: 98-107.
    • (2009) J Hum Genet , vol.54 , pp. 98-107
    • Betcheva, E.T.1    Mushiroda, T.2    Takahashi, A.3    Kubo, M.4    Karachanak, S.K.5    Zaharieva, I.T.6
  • 10
    • 79551619006 scopus 로고    scopus 로고
    • DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia
    • Blasi G, Napolitano F, Ursini G, Taurisano P, Romano R, Caforio G, et al. 2011. DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia. Proc Natl Acad Sci USA 108: 1158-1163.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1158-1163
    • Blasi, G.1    Napolitano, F.2    Ursini, G.3    Taurisano, P.4    Romano, R.5    Caforio, G.6
  • 11
    • 0034060459 scopus 로고    scopus 로고
    • Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics
    • DOI 10.1002/(SICI)1096-8628(200021)97:1<12::AID-AJMG3>3.0.CO;2-U
    • Cardno AG, and Gottesman, II. 2000. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet 97: 12-17. (Pubitemid 30257322)
    • (2000) American Journal of Medical Genetics - Seminars in Medical Genetics , vol.97 , Issue.1 , pp. 12-17
    • Cardno, A.G.1    Gottesman, I.I.2
  • 12
    • 78651312636 scopus 로고    scopus 로고
    • Brain anatomical abnormalities in high-risk individuals, fi rst-episode, and chronic schizophrenia: An activation likelihood estimation metaanalysis of illness progression
    • Chan RC, Di X, McAlonan GM, Gong QY. 2011. Brain anatomical abnormalities in high-risk individuals, fi rst-episode, and chronic schizophrenia: An activation likelihood estimation metaanalysis of illness progression. Schizophr Bull 37: 177-188.
    • (2011) Schizophr Bull , vol.37 , pp. 177-188
    • Chan, R.C.1    Di, X.2    McAlonan, G.M.3    Gong, Q.Y.4
  • 14
    • 0028261613 scopus 로고
    • Impaired attention, genetics, and the pathophysiology of schizophrenia
    • Cornblatt BA, Keilp JG. 1994. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20: 31-46. (Pubitemid 24071091)
    • (1994) Schizophrenia Bulletin , vol.20 , Issue.1 , pp. 31-46
    • Cornblatt, B.A.1    Keilp, J.G.2
  • 15
    • 0023790621 scopus 로고
    • The Continuous Performance Test, identical pairs version (CPT-IP): I New fi ndings about sustained attention in normal families
    • Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L. 1988. The Continuous Performance Test, identical pairs version (CPT-IP): I. New fi ndings about sustained attention in normal families. Psychiatry Res 26: 223-238.
    • (1988) Psychiatry Res , vol.26 , pp. 223-238
    • Cornblatt, B.A.1    Risch, N.J.2    Faris, G.3    Friedman, D.4    Erlenmeyer-Kimling, L.5
  • 16
    • 0024382649 scopus 로고
    • The Continuous Performance Test, Identical Pairs version: II. Contrasting attentional profiles in schizophrenic and depressed patients
    • DOI 10.1016/0165-1781(89)90188-1
    • Cornblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L. 1989. The continuous performance test, identical pairs version: II. Contrasting attentional profi les in schizophrenic and depressed patients. Psychiatry Res 29: 65-85. (Pubitemid 19189161)
    • (1989) Psychiatry Research , vol.29 , Issue.1 , pp. 65-85
    • Cornblatt, B.A.1    Lenzenweger, M.F.2    Erlenmeyer-Kimling, L.3
  • 17
    • 75749086304 scopus 로고    scopus 로고
    • Anatomy of bipolar disorder and schizophrenia: A meta-analysis
    • Ellison-Wright I, Bullmore E. 2010. Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophr Res 117: 1-12.
    • (2010) Schizophr Res , vol.117 , pp. 1-12
    • Ellison-Wright, I.1    Bullmore, E.2
  • 18
    • 0842310838 scopus 로고    scopus 로고
    • Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia
    • DOI 10.1038/ng1296
    • Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. 2004. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36: 131-137. (Pubitemid 38174370)
    • (2004) Nature Genetics , vol.36 , Issue.2 , pp. 131-137
    • Emamian, E.S.1    Hall, D.2    Birnbaum, M.J.3    Karayiorgou, M.4    Gogos, J.A.5
  • 19
    • 77950598371 scopus 로고    scopus 로고
    • Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action
    • Freyberg Z, Ferrando SJ, Javitch JA. 2010. Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am J Psychiatry 167: 388-396.
    • (2010) Am J Psychiatry , vol.167 , pp. 388-396
    • Freyberg, Z.1    Ferrando, S.J.2    Javitch, J.A.3
  • 21
    • 33748564313 scopus 로고    scopus 로고
    • Cognitive impairment and functional outcome in schizophrenia and bipolar disorder
    • Green MF. 2006. Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry 67(Suppl 9): 3-8; discussion 36-42. (Pubitemid 44369648)
    • (2006) Journal of Clinical Psychiatry , vol.67 , Issue.SUPPL. 9 , pp. 3-8
    • Green, M.F.1
  • 22
    • 0034859101 scopus 로고    scopus 로고
    • The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
    • DOI 10.1016/S0301-0082(01)00011-9, PII S0301008201000119
    • Grimes CA, Jope RS. 2001. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65: 391-426. (Pubitemid 32781670)
    • (2001) Progress in Neurobiology , vol.65 , Issue.4 , pp. 391-426
    • Grimes, C.A.1    Jope, R.S.2
  • 23
    • 84864334532 scopus 로고    scopus 로고
    • Interaction networks of lithium and valproate molec ular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling
    • Gupta A, Schulze TG, Nagarajan V, Akula N, Corona W, Jiang XY, et al. 2011. Interaction networks of lithium and valproate molec ular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. Pharmacogenom J. 12: 328-341.
    • (2011) Pharmacogenom J , vol.12 , pp. 328-341
    • Gupta, A.1    Schulze, T.G.2    Nagarajan, V.3    Akula, N.4    Corona, W.5    Jiang, X.Y.6
  • 27
    • 33745215607 scopus 로고    scopus 로고
    • Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat
    • Horwood JM, Dufour F, Laroche S, Davis S. 2006. Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 23: 3375-3384.
    • (2006) Eur J Neurosci , vol.23 , pp. 3375-3384
    • Horwood, J.M.1    Dufour, F.2    Laroche, S.3    Davis, S.4
  • 30
    • 55649099694 scopus 로고    scopus 로고
    • Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in fi rst-episode schizophrenia
    • Ikeda M, Yamanouchi Y, Kinoshita Y, Kitajima T, Yoshimura R, Hashimoto S, et al. 2008. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in fi rst-episode schizophrenia. Pharmacogenomics 9: 1437-1443.
    • (2008) Pharmacogenomics , vol.9 , pp. 1437-1443
    • Ikeda, M.1    Yamanouchi, Y.2    Kinoshita, Y.3    Kitajima, T.4    Yoshimura, R.5    Hashimoto, S.6
  • 31
    • 1342308071 scopus 로고    scopus 로고
    • The effects of clozapine on the GSK-3-mediated signaling pathway
    • DOI 10.1016/S0014-5793(04)00082-1
    • Kang UG, Seo MS, Roh MS, Kim Y, Yoon SC, Kim YS. 2004. The effects of clozapine on the GSK-3-mediated signaling pathway. FEBS Lett 560: 115-119. (Pubitemid 38264303)
    • (2004) FEBS Letters , vol.560 , Issue.1-3 , pp. 115-119
    • Kang, U.G.1    Seo, M.S.2    Roh, M.-S.3    Kim, Y.4    Yoon, S.C.5    Kim, Y.S.6
  • 32
    • 77954319396 scopus 로고    scopus 로고
    • Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorder
    • Karege F, Perroud N, Schurhoff F, Meary A, Marillier G, Burkhardt S, et al. 2010. Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorder. Genes Brain Behav 9: 503-511.
    • (2010) Genes Brain Behav , vol.9 , pp. 503-511
    • Karege, F.1    Perroud, N.2    Schurhoff, F.3    Meary, A.4    Marillier, G.5    Burkhardt, S.6
  • 34
    • 77049101392 scopus 로고    scopus 로고
    • No association between AKT1 polymorphism and schizophrenia: A case-control study in a Korean population and a meta-analysis
    • Lee KY, Joo EJ, Jeong SH, Kang UG, Roh MS, Kim SH, et al. 2010. No association between AKT1 polymorphism and schizophrenia: a case-control study in a Korean population and a meta-analysis. Neurosci Res 66: 238-245.
    • (2010) Neurosci Res , vol.66 , pp. 238-245
    • Lee, K.Y.1    Joo, E.J.2    Jeong, S.H.3    Kang, U.G.4    Roh, M.S.5    Kim, S.H.6
  • 35
    • 0035855710 scopus 로고    scopus 로고
    • A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala
    • Lin CH, Yeh SH, Lu KT, Leu TH, Chang WC, Gean PW. 2001. A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron 31: 841-851.
    • (2001) Neuron , vol.31 , pp. 841-851
    • Lin, C.H.1    Yeh, S.H.2    Lu, K.T.3    Leu, T.H.4    Chang, W.C.5    Gean, P.W.6
  • 37
    • 77953808090 scopus 로고    scopus 로고
    • Genetic association of the AKT1 gene with schizophrenia in a British population
    • Mathur A, Law MH, Megson IL, Shaw DJ, Wei J. 2010. Genetic association of the AKT1 gene with schizophrenia in a British population. Psychiatr Genet 20: 118-122.
    • (2010) Psychiatr Genet , vol.20 , pp. 118-122
    • Mathur, A.1    Law, M.H.2    Megson, I.L.3    Shaw, D.J.4    Wei, J.5
  • 38
    • 33748924655 scopus 로고    scopus 로고
    • Intermediate phenotypes and genetic mechanisms of psychiatric disorders
    • DOI 10.1038/nrn1993, PII NRN1993
    • Meyer-Lindenberg A, Weinberger DR. 2006. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7: 818-827. (Pubitemid 44435264)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.10 , pp. 818-827
    • Meyer-Lindenberg, A.1    Weinberger, D.R.2
  • 41
    • 19644400682 scopus 로고    scopus 로고
    • Failure to confi rm association between AKT1 haplotype and schizophrenia in a Japanese case-control population
    • Ohtsuki T, Inada T, Arinami T. 2004. Failure to confi rm association between AKT1 haplotype and schizophrenia in a Japanese case-control population. Mol Psychiatry 9: 981-983.
    • (2004) Mol Psychiatry , vol.9 , pp. 981-983
    • Ohtsuki, T.1    Inada, T.2    Arinami, T.3
  • 42
    • 0030750352 scopus 로고    scopus 로고
    • Frontal-striatal cognitive deficits in patients with chronic schizophrenia
    • DOI 10.1093/brain/120.10.1823
    • Pantelis C, Barnes TR, Nelson HE, Tanner S, Weatherley L, Owen AM, et al. 1997. Frontal-striatal cognitive defi cits in patients with chronic schizophrenia. Brain 120(Pt 10): 1823-1843. (Pubitemid 27443056)
    • (1997) Brain , vol.120 , Issue.10 , pp. 1823-1843
    • Pantelis, C.1    Barnes, T.R.E.2    Nelson, H.E.3    Tanner, S.4    Weatherley, L.5    Owen, A.M.6    Robbins, T.W.7
  • 45
    • 1542316171 scopus 로고    scopus 로고
    • Decreased cerebral activation during CPT performance: Structural and functional deficits in schizophrenic patients
    • DOI 10.1016/j.neuroimage.2003.10.027, PII S1053811903006773
    • Salgado-Pineda P, Junque C, Vendrell P, Baeza I, Bargallo N, Falcon C, et al. 2004. Decreased cerebral activation during CPT performance: structural and functional defi cits in schizophrenic patients. Neuroimage 21: 840-847. (Pubitemid 38314945)
    • (2004) NeuroImage , vol.21 , Issue.3 , pp. 840-847
    • Salgado-Pineda, P.1    Junque, C.2    Vendrell, P.3    Baeza, I.4    Bargallo, N.5    Falcon, C.6    Bernardo, M.7
  • 47
    • 25844437076 scopus 로고    scopus 로고
    • Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of european sib-pair families
    • DOI 10.1016/j.biopsych.2005.05.005, PII S0006322305005810
    • Schwab SG, Hoefgen B, Hanses C, Hassenbach MB, Albus M, Lerer B, et al. 2005. Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. Biol Psychiatry 58: 446-450. (Pubitemid 41393606)
    • (2005) Biological Psychiatry , vol.58 , Issue.6 , pp. 446-450
    • Schwab, S.G.1    Hoefgen, B.2    Hanses, C.3    Hassenbach, M.B.4    Albus, M.5    Lerer, B.6    Trixler, M.7    Maier, W.8    Wildenauer, D.B.9
  • 48
    • 77956270438 scopus 로고    scopus 로고
    • Epistatic and functional interactions of catechol-omethyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models
    • Sei Y, Li Z, Song J, Ren-Patterson R, Tunbridge EM, Iizuka Y, et al. 2010. Epistatic and functional interactions of catechol-omethyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. PLoS One 5: e10789.
    • (2010) PLoS One , vol.5
    • Sei, Y.1    Li, Z.2    Song, J.3    Ren-Patterson, R.4    Tunbridge, E.M.5    Iizuka, Y.6
  • 49
    • 50249135384 scopus 로고    scopus 로고
    • Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes
    • Shi J, Gershon ES, Liu C. 2008. Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res 104: 96-107.
    • (2008) Schizophr Res , vol.104 , pp. 96-107
    • Shi, J.1    Gershon, E.S.2    Liu, C.3
  • 50
    • 52949118071 scopus 로고    scopus 로고
    • Verbal and visual memory: Characterizing the clinical and intermediate phenotype in schizophrenia
    • Skelley SL, Goldberg TE, Egan MF, Weinberger DR, Gold JM. 2008. Verbal and visual memory: characterizing the clinical and intermediate phenotype in schizophrenia. Schizophr Res 105: 78-85.
    • (2008) Schizophr Res , vol.105 , pp. 78-85
    • Skelley, S.L.1    Goldberg, T.E.2    Egan, M.F.3    Weinberger, D.R.4    Gold, J.M.5
  • 51
    • 30344481921 scopus 로고    scopus 로고
    • Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes
    • DOI 10.1093/schbul/sbi048
    • Snitz BE, Macdonald AW, 3rd, Carter CS. 2006. Cognitive defi cits in unaffected fi rst-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull 32: 179-194. (Pubitemid 43063833)
    • (2006) Schizophrenia Bulletin , vol.32 , Issue.1 , pp. 179-194
    • Snitz, B.E.1    MacDonald III, A.W.2    Carter, C.S.3
  • 53
    • 53549099115 scopus 로고    scopus 로고
    • Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex
    • Sui L, Wang J, Li BM. 2008. Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex. Learn Mem 15: 762-776.
    • (2008) Learn Mem , vol.15 , pp. 762-776
    • Sui, L.1    Wang, J.2    Li, B.M.3
  • 55
    • 39449117941 scopus 로고    scopus 로고
    • Intermediate phenotypes in schizophrenia genetics redux: Is it a no brainer?
    • DOI 10.1038/sj.mp.4002145, PII 4002145
    • Tan HY, Callicott JH, Weinberger DR. 2008a. Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer? Mol Psychiatry 13: 233-238. (Pubitemid 351272661)
    • (2008) Molecular Psychiatry , vol.13 , Issue.3 , pp. 233-238
    • Tan, H.-Y.1    Callicott, J.H.2    Weinberger, D.R.3
  • 58
    • 0033956237 scopus 로고    scopus 로고
    • Schizophrenia: Genes and environment
    • DOI 10.1016/S0006-3223(99)00289-9, PII S0006322399002899
    • Tsuang M. 2000. Schizophrenia: genes and environment. Biol Psychiatry 47: 210-220. (Pubitemid 30077397)
    • (2000) Biological Psychiatry , vol.47 , Issue.3 , pp. 210-220
    • Tsuang, M.1
  • 60
    • 0038218463 scopus 로고
    • Revised. San Antonio, TX: Psychological Corporation
    • Wechsler D. 1987. Wechsler Memory Scale Manual, Revised. San Antonio, TX: Psychological Corporation.
    • (1987) Wechsler Memory Scale Manual
    • Wechsler, D.1
  • 64
    • 38049172954 scopus 로고    scopus 로고
    • Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
    • Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, et al. 2007. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci USA 104: 20552-20557.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20552-20557
    • Zhang, Y.1    Bertolino, A.2    Fazio, L.3    Blasi, G.4    Rampino, A.5    Romano, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.