Genetic association of the AKT1 gene with schizophrenia in a British population

Psychiatric Genetics

Volumn 20, Issue 3, 2010, Pages 118-122

  Mathur, Aditi ^a   Law, Matthew H ^a   Megson, Ian L ^a   Shaw, Duncan J ^b   Wei, Jun ^a  

^a UNIVERSITY OF THE HIGHLANDS AND ISLANDS   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

AKT GSK3B signalling; AKT1 gene; Association study; Schizophrenia; Single nucleotide polymorphism

Indexed keywords

ADULT; AKT1 GENE; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

ADULT; ALLELES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GREAT BRITAIN; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-AKT; SCHIZOPHRENIA;

EID: 77953808090     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/YPG.0b013e32833a2234     Document Type: Article

References (30)

1. Ali A, Hoeflich K, Woodgett J (2001). Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev 101:2527-2540.
2. Altomare D, Guo K, Cheng J, Sonoda G, Walsh K, Testa J (1995). Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene 11:1055-1060.
3. Bajestan S, Sabouri A, Nakamura M, Takashima H, Keikhaee M, Behdani F, et al. (2006). Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. Am J Med Genet (B) 141:383-386.
4. Beaulieu J, Zhang X, Rodriguiz R, Sotnikova T, Cools M,Wetsel W, et al. (2008). Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci U S A 105:1333-1338.
5. Bellacosa A, Franke T, Gonzalez-Portal M, Datta K, Taguchi T, Gardner J, et al. (1993). Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene 8:745-754.
6. Brodbeck D, Cron P, Hemmings B (1999). A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem 274:9133-9136.
7. Dokken B, Sloniger J, Henriksen E (2005). Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle. Am J Physiol Endocrinol Metab 288:E1188-E1194.
8. Dudbridge F (2008). Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66:87-98.
9. Emamian E, Hall D, Birnbaum M, Karayiorgou M, Gogos J (2004). Convergent evidence for impaired AKT1-GSK3 beta signaling in schizophrenia. Nat Genet 36:131-137.
10. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, et al. (2002). The structure of haplotype blocks in the human genome. Science 296:2225-2229.
11. Holt R, Bushe C, Citrome L (2005). Diabetes and schizophrenia 2005: are we any closer to understanding the link? J Psychopharmacol 19 (Suppl):56-65.
12. Ide M, Ohnishi T, Murayama M, Matsumoto I, Yamada K, Iwayama Y, et al. (2006). Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. J Neurochem 99:277-287.
13. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshiya Y, et al. (2006). Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. Int J Neuropsychopharmacol 9:77-81. (Pubitemid 43068336)
14. Jin H, Meyer J, Mudaliar S, Jeste D (2008). Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin. Schizophr Res 100:70-85.
15. Juvonen H, Reunanen A, Haukka J, Muhonen M, Suvisaari J, Arajärvi R, et al. (2007). Incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes mellitus. Arch Gen Psychiatry 64:894-899.
16. Kandel E, Hay N (1999). The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253:210-229.
17. Kohen D (2004). Diabetes mellitus and schizophrenia: historical perspective. Br J Psychiatry Suppl 47 (Suppl):S64-S66.
18. Liu Y, Fann C, Liu C, Wu J, Hung S, Chan H, Chen J, et al. (2006). Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population. Psychiatr Genet 16:39-41.
19. Norton N, Williams H, Dwyer S, Carroll L, Peirce T, Moskvina V, et al. (2007). Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophr Res 93:58-65.
20. Ohtsuki T, Inada T, Arinami T (2004). Failure to confirm association between AKT1 haplotype and schizophrenia in a Japanese case-control population. Mol Psychiatry 9:981-983.
21. Owada Y, Utsunomiya A, Yoshimoto T, Kondo H (1997). Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve. J Mol Neurosci 9:27-33.
22. Pinheiro A, Keefe R, Skelly T, Olarte M, Leviel K, Lange L, et al. (2007). AKT1 and neurocognition in schizophrenia. Aust N Z J Psychiatry 41:169-177.
23. Sanders A, Duan J, Levinson D, Shi J, He D, Hou C, et al. (2008). No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry 165: 497-506.
24. Schwab S, Hoefgen B, Hanses C, Hassenbach M, Albus M, Lerer B, et al. (2005). Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. Biol Psychiatry 58:446-450.
25. Souza R, Romano-Silva M, Lieberman J, Meltzer H, Wong A, Kennedy J (2008). Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. Psychopharmacology (Berl) 200:177-186.
26. Tan H, Nicodemus K, Chen Q, Li Z, Brooke J, Honea R, et al. (2008). Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest 118:2200-2208.
27. Thiselton D, Vladimirov V, Kuo P, McClay J, Wormley B, Fanous A, et al. (2008). AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biol Psychiatry 63:449-457.
28. Turunen J, Peltonen J, Pietiläinen O, HennahW, Loukola A, Paunio T, et al. (2007). The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. Schizophr Res 91:27-36.
29. Xu M, Xing Q, Zheng Y, Li S, Gao J, He G, et al. (2007). Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. J Clin Psychiatry 68: 1358-1367. (Pubitemid 47524515)
30. Zhao Z, Ksiezak-Reding H, Riggio S, Haroutunian V, Pasinetti G (2006). Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction. Schizophr Res 84:1-14.