Sustained attention deficits as markers of genetic susceptibility to schizophrenia

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 97, Issue 1, 2000, Pages 52-57

  Chen, Wei J ^a   Faraone, Stephen V ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NONE

Author keywords

Continuous performance test; Endophenotype; Heritability; Schizotypy; Symptom dimension; Vulnerability indicator

Indexed keywords

ATTENTION DEFICIT DISORDER; GENETIC MARKER; GENETIC RISK; GENETIC SUSCEPTIBILITY; HERITABILITY; HUMAN; MENTAL DISEASE; PERSONALITY DISORDER; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; GENETIC PREDISPOSITION; GENETICS;

BIOLOGICAL MARKER;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIOLOGICAL MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; SCHIZOPHRENIA;

EID: 0034059094     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(200021)97:1<52::AID-AJMG7>3.0.CO;2-6     Document Type: Review

References (47)

1. Addington J, Addington D. 1997. Attentional vulnerability indicators in schizophrenia and bipolar disorder. Schizophr Res 23:197-204.
2. Buchanan RW, Strauss ME, Breier A, Kirkpatrick B, Carpenter WT Jr.. 1997. Attentional impairments in deficit and non-deficit forms of schizophrenia. Am Psychiatry 154:363-370.
3. Chen WJ, Hsiao CK, Lin CCH. 1997. Schizotypy in community samples: the three-factor structure and correlation with sustained attention. J Abnorm Psychol 106: 649-654.
4. Chen WJ, Hsiao CK, Hsiao L-L. Hwu H-G. 1998a. Performance of the Continuous Performance Test among community samples. Schizophr Bull 24:163-174.
5. Chen WJ, Liu SK, Chang C-J, Lien Y-J, Chang Y-H, Hwu H-G. 1998b. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am J Psychiatry 155: 1214-1220.
6. Condray R, Steinhauer SR. 1992. Schizotypal personality disorder in individuals with and without schizophrenic relatives: similarities and contrasts in neurocognitive and clinical functioning. Schizophr Res 7:33-41.
7. Cormblatt BA, Risch NJ, Fans G, Friedman D, Erlenmeyer-Kimling L. 1988. The Continuous Perfomance Test. Identical Pairs Version: I. New findings about sustained attention in normal families. Psychiatry Res 26:223-238.
8. Cornblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L. 1989. The Continuous Performance Test. Identical Pairs Version: II. Contrasting attentional profiles in schizophrenic and depressed patients. Psychiatry Res 29:65-85.
9. Cornblatt BA, Keilp JG. 1994. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20:31-46.
10. Cornblatt B, Obuchowski M, Schnur B, O'Brien JD. 1997. Attention and clinical symptoms in schizophrenia. Psychiatr Quart 68:343-359.
11. Epstein JI, Keefe RSE, Roitman SL, Harvey PD, Mohs RC. 1996. Impact of neuroleptic medications on comtinuous performance test measures in schizophrenia. Biol Psychiatry 39:902-905.
12. Erickson WD, Yellin AM, Hopwood JH, Realmuto GM, Greenberg LM. 1984. The effects of neuroleptics on attention in adolescent schizophrenics. Biol Psychiatry 19: 745-753.
13. Faraone SV, Kremen WS, Lyons MJ, Pepple JR, Seidman LJ, Tsuang MT. 1995. Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes? Am J Psychiatry 152:1286-1290.
14. Faraone, SV, Tsuang D, Tsuang MT. 1999. Genetics of mental disorders: a guide for students, clinicians, and researchers. New York: Guilford.
15. Finkelstein JRJ, Cannon TD, Gur RE, Gur RC, Moberg P. 1997. Attentional dysfunctions in neuroleptic-naive and neuroleptic-withdrawn schizophrenic patients and their siblings. J Abnorm Psychol 106:203-212.
16. Gottesman II, Shields J. 1982. Schizophrenia: the epigenetic puzzle. Cambridge: Cambridge University Press.
17. Greenberg LM, Waldman ID. 1993. Developmental normative data on the Test of Variables of Attention (T.O.V.A.). J Child Psychol Psychiatry 34:1019-1030.
18. Grove WM, Lebow BS, Clementz BA, Cerri A, Medus C, Iacono WG. 1991. Familial prevalence and coaggregation of schizotypal indicators: a multitrait family study. J Abnorm Psychol 100:115-121.
19. Hain H, Maier W, Klinger T, Franke P. 1993. Positive/negative symptomatology and experimental measures of attention in schizophrenia. Psychopathology 26:62-68.
20. Harvey PD, Keefe RSE, Mitroupolou V, Dupre R, Roitman SL, Mohs RC, Siever LJ. 1996. Information-processing markers of vulnerability to schizophrenia: performance of patients with schizotypal and nonschizotypal personality disorders. Psychiatry Res 60:49-56.
21. Johnstone EC, Frith CD. 1996. Validation of three dimensions of schizophrenic symptoms in a large unselected sample of patients. Psychol Med 26:669-679.
22. Kendler KS, Ochs AL, Gorman AM, Hewitt JK, Ross DE, Mirsky AF. 1991. The structure of schizotypy: a pilot multitrait twin study. Psychiatry Res 36:19-36.
23. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. 1993. The Roscommon Family Study: III. Schizophrenia-related personality disorders in relatives. Arch Gen Psychiatry 50:781-788.
24. Lenzenweger MF, Cornblatt BA, Putnick M. 1991. Schizotypy and sustained attention. J Abnorm Psychol 100:84-89.
25. Lin CCH, Hsiao CK, Chen WJ. 1999. Development of sustained attention assessed using the Continuous Performance Test among children 6-15 years of age. J Abnorm Child Psychol 27:403-412.
26. Liu SK, Hwu H-G, Chen WJ. 1997. Clinical symptom dimensions and deficits on the Continuous Performance Test in schizophrenia. Schizophr Res 25:211-219.
27. Liu SK, Chen WJ, Chang C-J, Lin H-N. 2000. Effects of a typical neuroleptics on sustained attention deficits in schizophrenia: a trial of rispendone versus haloperidol. Neuropsychopharmacology 22:311-319.
28. Losier BJ, McGrath PJ, Klein RM. 1996. Error patterns on the Continuous Performance Test in non-medicated and medicated samples of children with and without ADHD: a meta-analytic review. J Child Psychol Psychiatry 37:971-987.
29. Mirsky AF, Yardley SL, Jones BP, Walsh D, Kendler KS. 1995. Analysis of the attention deficit in schizophrenia: a study of patients and their relatives in Ireland. J Psychiatr Res 29:23-42.
30. Moldin SO, Erlenmeyer-Kimling L. 1994. Measuring liability to schizophrenia: progress report 1994: editors' introduction. Schizophr Bull 20:25-29.
31. Mussgay L, Hertwig R. 1990. Signal detection indices in schizophrenics on a visual, auditory and bimodal Continuous Performance Test. Schizophr Res 3:303-310.
32. Nelson EB, Sax KW, Strakowski SM. 1998. Attentional performance in patients with psychotic and nonpsychotic major depression and schizophrenia. Am J Psychiatry 155: 137-139.
33. Nuechterlein KH. 1983. Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. J Abnorm Psychol 92:4-28.
34. Nuechterlein KH, Edell ES, Norris M, Dawson ME. 1986. Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophr Bull 12:408-426.
35. Nuechterlein KH. 1991. Vigilance in schizophrenia and related disorders. In: Steinhauer SR, Gruzelier JH, Zubin J, editors. Handbook of schizophrenia, vol. 5: neuropsychology, psychophysiology and information processing. Amsterdam: Elsevier. p 397-433.
36. Nuechterlein KH, Dawson ME, Ventura J, Fogelson D, Gitlin M, Mintz J. 1991. Testing vulnerability models: stability of potential vulnerability indicators across clinical state. In: Häfner H, Gattaz WF, editors. Search for the causes of schizophrenia, vol. II. Berlin: Springer-Verlag. p 177-191.
37. Obiols JE, García-Domingo M, de Trinchería I, Doménech E. 1993. Psychometric schizotypy and sustained attention in young males. Person Indiv Diff 14:381-384.
38. Obiols JE, Serrano F, Barrantes N, Garcia-Marimon M, Gras S, Bosch E, Caparros B, Carandell F. 1997. Frontal dysfunction and psychosis proneness in CPT-linked vulnerable adolescents. Person Indiv Diff 23:677-683.
39. Orzack MH, Kornetsky C, Freeman H. 1967. The effect of daily carphenazine on attention in the schizophrenic patient. Psychopharmacologia 8:31-38.
40. Pandurangi AK, Sax KW, Pelonero AL, Goldberg SC. 1994. Sustained attention and positive formal disorder in schizophrenia. Schizophr Res 13:109-116.
41. Risch N. 1990. Linkage strategies for genetically complex traits, II: the power of affected relative pairs. Am J Hum Genet 46:229-241.
42. Roitman SEL, Keefe RSE, Harvey PD, Siever LJ, Mohs RC. 1997. Attentional and eye tracking deficits correlate with negative symptoms in schizophrenia. Schizophr Res 26: 139-146
43. Rosvold HE, Mirsky AF, Sarason I, Bransome ED Jr, Beck LH. 1956. A Continuous Performance Test of brain damage. J Consult Psychol 20:343-350.
44. Rund BR, Orbeck AL, Landro NI. 1992. Vigilance deficits in schizophrenics and affectively disturbed patients. Acta Psychiatr Scand 86:207-212.
45. Spohn HE, Lacoursiere RB, Thompson K, Coyne L. 1977. Phenothiazine effects on psychological and psychophysiological dysfunction in chronic schizophrenics. Arch Gen Psychiatry 34:633-644.
46. Strauss ME, Buchanan RW, Hale J. 1993. Relations between attentional deficits and clinical symptoms in schizophrenic outpatients. Psychiatry Res 47:205-213.
47. Walker E. 1981. Attentional and neuromotor functions of schizophrenics, schizoaffectives, and patients with other affective disorders. Arch Gen Psychiatry 38:1355-1358.