Wortmannin efficiently suppresses the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population

Journal of Radiation Research

Volumn 54, Issue 2, 2013, Pages 221-229

  Masunaga, Shin Ichiro ^a   Sakurai, Yoshinori ^b   Tanaka, Hiroki ^b   Suzuki, Minoru ^a   Kondo, Natsuko ^a   Narabayashi, Masaru ^a   Maruhashi, Akira ^b   Ono, Koji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

caffeine; pimonidazole; Quiescent cell; recovery from radiation induced damage; wortmannin

Indexed keywords

EID: 84874874262     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1093/jrr/rrs094     Document Type: Article

References (23)

1. Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004;206:198-206.
2. Masunaga S, Ono K. Significance of the response of quiescent cell populations within solid tumors in cancer therapy. J Radiat Res 2002;43:11-25.
3. Masunaga S, Ono K, Suzuki M, et al. Radiobiologic significance of apoptosis and micronucleation in quiescent cells within solid tumors following γ-ray irradiation. Int J Radiat Oncol Biol Phys 2001;49:1361-8.
4. Ljungkvist AS, Bussink J, Rijken PF, et al. Changes in tumor hypoxia measured with a double hypoxic marker technique. Int J Radiat Oncol Biol Phys 2000;48:1529-38.
5. Houtgraaf JH, Versmissena J, van der Giessen WJ. A concise review of DNA damage checkpoints and repair in mammalian cells. Cardiovasc Revascularization Med 2006;7:165-72.
6. Karran P. DNA double strand break repair in mammalian cells. Curr Opin Genet Dev 2000;10:144-50.
7. Hashimoto M, Rao S, Tokuno O, et al. DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway. J Radiat Res 2003;44:151-9.
8. Hoekstra MF. Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family. Curr Opin Genet Dev 1997;7:170-5.
9. Boehm L, Roos WP, Serafin AM. Inhibition of DNA repair by pentoxifyline and related methylxanthine derivatives. Toxicology 2003;193:153-60.
10. Masunaga S, Ono K, Suzuki M, et al. Radiosensitization effect by combination with paclitaxel in vivo including the effect on intratumor quiescent cells. Int J Radiat Oncol Biol Phys 2001;50:1063-72.
11. Masunaga S, Ono K, Sakurai Y, et al. Evaluation of apoptosis and micronucleation induced by reactor neutron beams with two different cadmium ratios in total and quiescent cell populations within solid tumors. Int J Radiat Oncol Biol Phys 2001;51:828-39.
12. Masunaga S, Nagasawa H, Liu Y, et al. Evaluation of the radiosensitivity of the oxygenated tumor cell fractions in quiescent cell populations within solid tumors. Radiat Res 2010;174:459-66.
13. Masunaga S, Ono K, Abe M. A method for the selective measurement of the radiosensitivity of quiescent cells in solid tumors-combination of immunofluorescence staining to BUdR and micronucleus assay. Radiat Res 1991;125:243-7.
14. O'Brien CA, Kreso A, Dick JE. Cancer stem cells in solid tumors: an overview. Semin Radiat Oncol 2009;19:71-6.
15. Hill RP, Marie-Egyptienne DT, Hedley DW. Cancer stem cells, hypoxia and metastasis. Semin Radiat Oncol 2009;19:106-11.
16. Diehn M, Cho RW, Clarke MF. Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol 2009;19:78-85.
17. Hall EL, Giaccia AJ. Fractionated Radiation and the dose-rate effect. In: Hall EL, Giaccia AJ (eds). Radiobiology for the Radiologist. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2012, 67-85.
18. Wang H, Wang X, Iliakis G, et al. Caffeine could not effectively sensitize homologous recombination repair deficient cells to ionizing radiation induced cell killing. Radiat Res 2003;159:420-5.
19. Kubota N, Ozawa F, Okada S, et al. The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but proliferating MG-63 human osteosarcoma cells to radiation. Cancer Lett 1998;133:161-7.
20. Horn HF, Vousden KH. Coping with stress: multiple ways to activate p53. Oncogene 2007;26:1306-16.
21. Masunaga S, Ono K, Takahashi A, et al. Radiobiological characteristics of solid tumors depending on the p53 status of the tumor cells, with emphasis on the response of intratumor quiescent cells. Eur J Cancer 2002;38:18-727.
22. Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, et al. Reduced expression of hypoxia-inducible factor-1α in perinecrotic regions of solid tumors. Cancer Res 2005;65:7259-66.
23. Kishiji M, Kagayama Y, Pete EA, et al. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004;23:1949-56.