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Volumn 9, Issue 2, 2012, Pages 874-880

Methylenetetrahydrofolate reductase (Mthfr C677t) gene polymorphism effect on development of diabetic nephropathy in Egyptien patients with type 2 diabetes mellitus

Author keywords

C677T Polymorphism; Diabetic nephropathy; Homocysteine; MTHFR; Type 2 diabetes mellitus

Indexed keywords


EID: 84874850467     PISSN: 10978135     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (42)
  • 1
    • 0030934033 scopus 로고    scopus 로고
    • Risk factors for development of incipient and overt diabetic nephropathy in patients with non-insulin dependent diabetes mellitus: Prospective, observational study
    • Gall M. A., Hougaard P., Borch-Johnsen K., Parving H. H., Risk factors for development of incipient and overt diabetic nephropathy in patients with non-insulin dependent diabetes mellitus: prospective, observational study, BMJ, 1997; 314: 783-788.
    • (1997) BMJ , vol.314 , pp. 783-788
    • Gall, M.A.1    Hougaard, P.2    Borch-Johnsen, K.3    Parving, H.H.4
  • 3
    • 0033802994 scopus 로고    scopus 로고
    • The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients
    • Shpichinetsky V., Raz I., Friedlander Y., Goldschmidt N., Wexler I. D., Ben-Yehuda A., Friedman G. The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients. J Nutr. 2000; 130: 2493-2497.
    • (2000) J Nutr. , vol.130 , pp. 2493-2497
    • Shpichinetsky, V.1    Raz, I.2    Friedlander, Y.3    Goldschmidt, N.4    Wexler, I.D.5    Ben-Yehuda, A.6    Friedman, G.7
  • 4
    • 15944362595 scopus 로고    scopus 로고
    • Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: A metaanalysis
    • Zintzaras E., Stefanidis I. Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a metaanalysis. J Hum Genet. 2005; 50: 84-91.
    • (2005) J Hum Genet. , vol.50 , pp. 84-91
    • Zintzaras, E.1    Stefanidis, I.2
  • 5
    • 0025370739 scopus 로고
    • Familial predisposition to renal disease in 2 generations of Pima-Indians with type-2 (non insulin dependent) diabetes mellitus
    • Pettitt D. J., Saad M. F., Bennett P. H., Nelson R. G., Knowler, W. C. Familial predisposition to renal disease in 2 generations of Pima-Indians with type-2 (non insulin dependent) diabetes mellitus. Diabetologia 1990; 33: 438.
    • (1990) Diabetologia , vol.33 , pp. 438
    • Pettitt, D.J.1    Saad, M.F.2    Bennett, P.H.3    Nelson, R.G.4    Knowler, W.C.5
  • 6
    • 0000167774 scopus 로고
    • Disorders of transsulfuration
    • In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds., 6th ed. New York: McGraw-Hill
    • Mudd S. H., Levy H. L., Skovby F. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease. 6th ed. New York: McGraw-Hill, 1995: 1279-1326.
    • (1995) The Metabolic Basis of Inherited Disease , pp. 1279-1326
    • Mudd, S.H.1    Levy, H.L.2    Skovby, F.3
  • 8
    • 0032497143 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients
    • Neugebauer S., Baba T., Watanabe T. Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients. Lancet 1998; 352: 454.
    • (1998) Lancet , vol.352 , pp. 454
    • Neugebauer, S.1    Baba, T.2    Watanabe, T.3
  • 10
    • 0034061368 scopus 로고    scopus 로고
    • Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis
    • Isotalo P. A., Donnelly J. G. Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis. Mol Diagn 2000; 5: 59-66.
    • (2000) Mol Diagn , vol.5 , pp. 59-66
    • Isotalo, P.A.1    Donnelly, J.G.2
  • 11
    • 0032972277 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is a risk factor for coronary arteriosclerosis in Japanese patients with type 2 diabetes
    • Mar
    • Okada E., Oida K., Tada H., Asazuma K., Eguchi K., Tohda G., Kosaka S., Takahashi S, Miyamori I. Hyperhomocysteinemia is a risk factor for coronary arteriosclerosis in Japanese patients with type 2 diabetes. Diabetes Care. 1999 Mar; 22 (3): 484-490.
    • (1999) Diabetes Care. , vol.22 , Issue.3 , pp. 484-490
    • Okada, E.1    Oida, K.2    Tada, H.3    Asazuma, K.4    Eguchi, K.5    Tohda, G.6    Kosaka, S.7    Takahashi, S.8    Miyamori, I.9
  • 12
    • 0030610090 scopus 로고    scopus 로고
    • The mutation C677T in the methylenetetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
    • Arruda V. R., von Zuben P. M., Chiaparini L. C., Annichino-Bizzacchi J., Costa F. F. The mutation C677T in the methylenetetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost 1997; 77: 818-821.
    • (1997) Thromb Haemost , vol.77 , pp. 818-821
    • Arruda, V.R.1    von Zuben, P.M.2    Chiaparini, L.C.3    Annichino-Bizzacchi, J.4    Costa, F.F.5
  • 13
    • 0028845307 scopus 로고
    • Prospective study of total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry I. J., Refsum H., Morris R. W., Ebrahim S. B., Ueland P. M., Shaper A. G. Prospective study of total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995; 346: 1395-1398.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 15
    • 0032865186 scopus 로고    scopus 로고
    • A common mutation A1298C in human methylenetetrahydrofolate reductase gene: Association with plasma total homocysteine and folate concentration
    • Friedman G., Goldschmidt N., Friedlander Y., Ben-Yehuda A., Selhub J., Babaey S., Mendel M., Kidron M., Bar-On H. A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentration. J. Nutr. 1999; 129: 1656-1661.
    • (1999) J. Nutr. , vol.129 , pp. 1656-1661
    • Friedman, G.1    Goldschmidt, N.2    Friedlander, Y.3    Ben-Yehuda, A.4    Selhub, J.5    Babaey, S.6    Mendel, M.7    Kidron, M.8    Bar-On, H.9
  • 16
    • 4444233897 scopus 로고    scopus 로고
    • Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease
    • W. Y. Almawi, G. Ameen, H. Tamim, R. R. Finan, N. Irani-Hakime. Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease, J. Thromb. Thrombol. 2004; 17: 199-205.
    • (2004) J. Thromb. Thrombol. , vol.17 , pp. 199-205
    • Almawi, W.Y.1    Ameen, G.2    Tamim, H.3    Finan, R.R.4    Irani-Hakime, N.5
  • 18
    • 0026088764 scopus 로고
    • Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations
    • Kang S. S., Wong P. W., Bock H. G., Horwitz A., Grix A. Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations. Am J Hum Genet 1991; 48: 546-551.
    • (1991) Am J Hum Genet , vol.48 , pp. 546-551
    • Kang, S.S.1    Wong, P.W.2    Bock, H.G.3    Horwitz, A.4    Grix, A.5
  • 19
    • 1842852484 scopus 로고    scopus 로고
    • Hyperhomocyteinemia and increased risk of retinopathy: A cross-sectional, case-control study in patients with type 2 diabetes (Letter)
    • Parvanova A, Iliev I, Dimitrov BD, Arnoldi F, Zaletel J, Remuzzi G, Ruggenenti P: Hyperhomocyteinemia and increased risk of retinopathy: a cross-sectional, case-control study in patients with type 2 diabetes (Letter). Diabetes Care 25: 2361, 2002.
    • (2002) Diabetes Care , vol.25 , pp. 2361
    • Parvanova, A.1    Iliev, I.2    Dimitrov, B.D.3    Arnoldi, F.4    Zaletel, J.5    Remuzzi, G.6    Ruggenenti, P.7
  • 20
    • 0031051528 scopus 로고    scopus 로고
    • Defective homocysteine metabolism as a risk factor for diabetic retinopathy (Letter)
    • Neugebauer S. B., Baba T., Kurokawa K., Watanabe T., Defective homocysteine metabolism as a risk factor for diabetic retinopathy (Letter), Lancet 1997; 349: 473-474.
    • (1997) Lancet , vol.349 , pp. 473-474
    • Neugebauer, S.B.1    Baba, T.2    Kurokawa, K.3    Watanabe, T.4
  • 21
    • 0025911079 scopus 로고
    • Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in type 1 diabetes mellitus
    • Hultberg B, Agardh E, Andersson A, Brattström L, Isaksson A, Israelsson B, Agardh CD. Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in type 1 diabetes mellitus, Scand J Clin Lab Invest. 1991; 51 (3): 277-282.
    • (1991) Scand J Clin Lab Invest. , vol.51 , Issue.3 , pp. 277-282
    • Hultberg, B.1    Agardh, E.2    Andersson, A.3    Brattström, L.4    Isaksson, A.5    Israelsson, B.6    Agardh, C.D.7
  • 22
    • 1842334456 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20: 1183-1201.
    • (1997) Diabetes Care , vol.20 , pp. 1183-1201
  • 23
    • 1042302788 scopus 로고    scopus 로고
    • Nephropathy in diabetes (Position Statement)
    • American Diabetes Association
    • American Diabetes Association: Nephropathy in diabetes (Position Statement). Diabetes Care 2004; 27 (Suppl. 1): S79-S83.
    • (2004) Diabetes Care , vol.27 , Issue.SUPPL. 1
  • 24
    • 0026633925 scopus 로고
    • Hyperhomocysteinemia as a risk factor for occlusive vascular disease
    • Kang S. S., Wong P. W., Malinow M. R. Hyperhomocysteinemia as a risk factor for occlusive vascular disease. Ann. Rev. Nutr. 1992; 12: 279-298.
    • (1992) Ann. Rev. Nutr. , vol.12 , pp. 279-298
    • Kang, S.S.1    Wong, P.W.2    Malinow, M.R.3
  • 25
    • 0344426698 scopus 로고    scopus 로고
    • US Renal Data System, Bethesda, MD, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases
    • US Renal Data System: USRDS 2003 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2003.
    • (2003) USRDS 2003 Annual Data Report: Atlas of End-Stage Renal Disease in the United States
  • 26
    • 0034708947 scopus 로고    scopus 로고
    • The risk of cardiovascular disease mortality associated with microalbuminuria and gross proteinuria in persons with older-onset diabetes mellitus
    • Valmadrid C. T., Klein R., Moss S. E., Klein B. E. The risk of cardiovascular disease mortality associated with microalbuminuria and gross proteinuria in persons with older-onset diabetes mellitus. Arch Intern Med 2000; 160: 1093-1100.
    • (2000) Arch Intern Med , vol.160 , pp. 1093-1100
    • Valmadrid, C.T.1    Klein, R.2    Moss, S.E.3    Klein, B.E.4
  • 27
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg, I., Tran, P., Christensen, B., Sibani, S., and Rozen, R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol. Genet. Metab. 1998; 64: 169-172.
    • (1998) Mol. Genet. Metab. , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 28
    • 0032573077 scopus 로고    scopus 로고
    • A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
    • Bagley, P. J., and Selhub, J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc. Natl. Acad. Sci. 1998; 95: 13217-13220.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 13217-13220
    • Bagley, P.J.1    Selhub, J.2
  • 29
    • 0029816188 scopus 로고    scopus 로고
    • Molecular genetics of methylenetetrahydrofolate reductase deficiency
    • Rozen R. Molecular genetics of methylenetetrahydrofolate reductase deficiency. J Inher Metab Dis 1996; 19: 589-594.
    • (1996) J Inher Metab Dis , vol.19 , pp. 589-594
    • Rozen, R.1
  • 30
    • 10944248087 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism associated with susceptibility to coronary heart disease in Chinese type 2 diabetic patients
    • Sun, J; Xu, Y; Xue, J; Zhu, Y; Lu, H. Methylenetetrahydrofolate reductase polymorphism associated with susceptibility to coronary heart disease in Chinese type 2 diabetic patients. Mol Cell Endocrinol. 2005; 229: 95-101.
    • (2005) Mol Cell Endocrinol. , vol.229 , pp. 95-101
    • Sun, J.1    Xu, Y.2    Xue, J.3    Zhu, Y.4    Lu, H.5
  • 32
    • 84859239810 scopus 로고    scopus 로고
    • Is C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?
    • Cui WP, Du B, Jia Y, Zhou WH, Liu SM, Cui YC, Ma FZ, Luo P, Miao LN. Is C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?. ARCH MED RES. 2012; 43 (1): 42-50.
    • (2012) ARCH MED RES. , vol.43 , Issue.1 , pp. 42-50
    • Cui, W.P.1    Du, B.2    Jia, Y.3    Zhou, W.H.4    Liu, S.M.5    Cui, Y.C.6    Ma, F.Z.7    Luo, P.8    Miao, L.N.9
  • 33
    • 38949127276 scopus 로고    scopus 로고
    • MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients
    • Maeda M., Yamamoto I., Fukuda M., Motomura T., Nishida M., Nonen S., Fujio Y., Kasayama S., Azuma J. MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients. J Diabetes Complications. 2008; 22 (2): 119-125.
    • (2008) J Diabetes Complications. , vol.22 , Issue.2 , pp. 119-125
    • Maeda, M.1    Yamamoto, I.2    Fukuda, M.3    Motomura, T.4    Nishida, M.5    Nonen, S.6    Fujio, Y.7    Kasayama, S.8    Azuma, J.9
  • 34
    • 0032480790 scopus 로고    scopus 로고
    • Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults
    • Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Bones C, Newcombe RG, Lewis MJ. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 1998; 98 (18): 1848-1852.
    • (1998) Circulation. , vol.98 , Issue.18 , pp. 1848-1852
    • Bellamy, M.F.1    McDowell, I.F.2    Ramsey, M.W.3    Brownlee, M.4    Bones, C.5    Newcombe, R.G.6    Lewis, M.J.7
  • 35
    • 0035923560 scopus 로고    scopus 로고
    • Homocysteine impairs the nitric oxide synthase pathway: Role of asymmetric dimethylarginine
    • Stuhlinger, M. C., Tsao, P. S., Her, J. H., Kimoto, M., Balint, R. F., Cooke, J. P. Homocysteine impairs the nitric oxide synthase pathway: Role of asymmetric dimethylarginine. Circulation, 2001; 104: 2569-2575.
    • (2001) Circulation , vol.104 , pp. 2569-2575
    • Stuhlinger, M.C.1    Tsao, P.S.2    Her, J.H.3    Kimoto, M.4    Balint, R.F.5    Cooke, J.P.6
  • 37
    • 0032714729 scopus 로고    scopus 로고
    • The graded effect of hyperhomocysteinemia on the severity and extent of coronary atherosclerosis
    • Chao C. L., Tsai H. H., Lee C. M., Hsu S. M., Kao J. T., Chien K. L., Sung F. C., Lee Y. T. The graded effect of hyperhomocysteinemia on the severity and extent of coronary atherosclerosis. Atherosclerosis. 1999; 147 (2): 379-386.
    • (1999) Atherosclerosis. , vol.147 , Issue.2 , pp. 379-386
    • Chao, C.L.1    Tsai, H.H.2    Lee, C.M.3    Hsu, S.M.4    Kao, J.T.5    Chien, K.L.6    Sung, F.C.7    Lee, Y.T.8
  • 38
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer R. H., Wilson B. D., Gubler D. B., Fitzgerald L. A., Rodgers G. M. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells, Arterioscler Thromb. 1993; 13 (9): 1327-1333.
    • (1993) Arterioscler Thromb. , vol.13 , Issue.9 , pp. 1327-1333
    • Fryer, R.H.1    Wilson, B.D.2    Gubler, D.B.3    Fitzgerald, L.A.4    Rodgers, G.M.5
  • 39
    • 0034254728 scopus 로고    scopus 로고
    • Induction of monocyte tissue factor expression by homocysteine: A possible mechanism for thrombosis
    • Khajuria A., Houston D. S. Induction of monocyte tissue factor expression by homocysteine: a possible mechanism for thrombosis, Blood. 2000; 96 (3): 966-972.
    • (2000) Blood. , vol.96 , Issue.3 , pp. 966-972
    • Khajuria, A.1    Houston, D.S.2
  • 40
    • 0035810980 scopus 로고    scopus 로고
    • Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: Implications for vascular disease
    • 5
    • Poddar R., Sivasubramanian N., DiBello P. M., Robinson K., Jacobsen D. W. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation. 2001 5; 103 (22): 2717-2723.
    • (2001) Circulation. , vol.103 , Issue.22 , pp. 2717-2723
    • Poddar, R.1    Sivasubramanian, N.2    DiBello, P.M.3    Robinson, K.4    Jacobsen, D.W.5


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