Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients

Lancet

Volumn 352, Issue 9126, 1998, Pages 454-

  Neugebauer, Sabine ^a   Baba, Tsuneharu ^b   Watanabe, Tsuyoshi ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); MUTANT PROTEIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DNA POLYMORPHISM; ENZYME ACTIVITY; GENE FREQUENCY; GENETIC RISK; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; JAPAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

EID: 0032497143     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)79188-1     Document Type: Article

References (5)

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2. 2 Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-13.
3. 3 Morita H, Taguchi JI, Kurihara H, et al. Genetic polymorphism of 5,10-Methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 1997; 95: 2032-36.
4. 4 Neugebauer S, Baba T, Watanabe T. Defective homocysteine metabolism as a risk factor for diabetic retinopathy. Lancet 1997; 349: 473-74.
5. 5 Mogensen CE. Microalbuminuria predicts clinical and early mortality in maturity onset diabetes. N Engl J Med 1984; 310: 356-60.