Defective homocysteine metabolism as a risk factor for diabetic retinopathy

Lancet

Volumn 349, Issue 9050, 1997, Pages 473-474

  Neugebauer, Sabine ^a   Baba, Tsuneharu ^b   Kurokawa, Kiyoshi ^b   Watanabe, Tsuyoshi ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; METHIONINE;

ADULT; ARTICLE; ATHEROGENESIS; BLINDNESS; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENZYME DEFICIENCY; GENE FREQUENCY; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

EID: 0031051528     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)61185-3     Document Type: Article

References (5)

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2. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-13.
3. Engbersen AMT, Franken DG, Boers GHJ, Stevens EMB, Trijbels FJM, Blom HJ. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am J Hum Genet 1995; 56: 142-50.
4. Boers GHJ, Smals AGH, Trijbels FJM. Heterozygosity for homocysteine in premature cerebral occlusive arterial disease. N Engl J Med 1985; 313: 709-15.
5. Ueland P, Refsum H. Plasma homocysteine a risk factor for vascular disease: plasma levels in health, disease and drug therapy. J Lab Clin Med 1989; 114: 473-501.