-
4
-
-
0026540999
-
Comparing evolvability and variability of quantitative traits
-
Houle D, (1992) Comparing evolvability and variability of quantitative traits. Genetics 130: 195-204.
-
(1992)
Genetics
, vol.130
, pp. 195-204
-
-
Houle, D.1
-
5
-
-
19544386730
-
Evolvability, stabilizing selection, and the problem of stasis
-
Oxford University press
-
Hansen T, Houle D (2004) Evolvability, stabilizing selection, and the problem of stasis. In: The evolutionary biology of complex phenotypes, Oxford University press. pp. 130-150.
-
(2004)
The evolutionary biology of complex phenotypes
, pp. 130-150
-
-
Hansen, T.1
Houle, D.2
-
6
-
-
2942559054
-
Direct selection on male attractiveness and female preference fails to produce a response
-
Hall M, Lindholm A, Brooks R, (2004) Direct selection on male attractiveness and female preference fails to produce a response. BMC Evolutionary Biology 4: 1-10.
-
(2004)
BMC Evolutionary Biology
, vol.4
, pp. 1-10
-
-
Hall, M.1
Lindholm, A.2
Brooks, R.3
-
8
-
-
0035007367
-
Epistasis and the Mutation Load: A Measurement-Theoretical Approach
-
Hansen TF, Wagner GP, (2001) Epistasis and the Mutation Load: A Measurement-Theoretical Approach. Genetics 158: 477-485.
-
(2001)
Genetics
, vol.158
, pp. 477-485
-
-
Hansen, T.F.1
Wagner, G.P.2
-
9
-
-
76249110585
-
Abundant Genetic Variation+Strong Selection = Multivariate Genetic Constraints: A Geometric View of Adaptation
-
Walsh B, Blows MW, (2009) Abundant Genetic Variation+Strong Selection = Multivariate Genetic Constraints: A Geometric View of Adaptation. Annual Review of Ecology, Evolution, and Systematics 40: 41-59.
-
(2009)
Annual Review of Ecology, Evolution, and Systematics
, vol.40
, pp. 41-59
-
-
Walsh, B.1
Blows, M.W.2
-
11
-
-
58049217860
-
-
Hindorff LA, Junkins HA, Hall PN, Mehta JP, Manolio TA (2010). A Catalog of Published Genome- Wide Association Studies, available at http://www.genome.gov/gwastudies. Accessed 12/10/2010.
-
(2010)
A Catalog of Published Genome- Wide Association Studies
-
-
Hindorff, L.A.1
Junkins, H.A.2
Hall, P.N.3
Mehta, J.P.4
Manolio, T.A.5
-
12
-
-
84891866195
-
The case of the missing heritability
-
Maher B, (2008) The case of the missing heritability. Nature 456.
-
(2008)
Nature
, vol.456
-
-
Maher, B.1
-
13
-
-
76549092570
-
Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies
-
Eyre-Walker A, (2010) Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. Proceedings of the National Academy of Sciences of the United States of America 107 Suppl: 1752-6.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, Issue.SUPPL.
, pp. 1752-1756
-
-
Eyre-Walker, A.1
-
14
-
-
77954140531
-
Common SNPs explain a large proportion of the heritability for human height
-
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42: 565-569.
-
(2010)
Nat Genet
, vol.42
, pp. 565-569
-
-
Yang, J.1
Benyamin, B.2
McEvoy, B.P.3
Gordon, S.4
Henders, A.K.5
-
15
-
-
0016814243
-
The maintenance of genetic variability by mutation in a polygenic character with linked loci
-
Lande R, (1975) The maintenance of genetic variability by mutation in a polygenic character with linked loci. Genetical research 26: 221-235.
-
(1975)
Genetical Research
, vol.26
, pp. 221-235
-
-
Lande, R.1
-
17
-
-
3442894519
-
Epistasis: too often neglected in complex trait studies?
-
Carlborg O, Haley CS, (2004) Epistasis: too often neglected in complex trait studies? Nature reviews Genetics 5: 618-25.
-
(2004)
Nature Reviews Genetics
, vol.5
, pp. 618-625
-
-
Carlborg, O.1
Haley, C.S.2
-
18
-
-
54149088214
-
Epistasis - the essential role of gene interactions in the structure and evolution of genetic systems
-
Phillips PC, (2008) Epistasis- the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet 9: 855-867.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 855-867
-
-
Phillips, P.C.1
-
19
-
-
0345411335
-
The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases
-
Moore J, (2003) The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases. Human Heredity 56: 73-82.
-
(2003)
Human Heredity
, vol.56
, pp. 73-82
-
-
Moore, J.1
-
20
-
-
0001771498
-
Evolution in Mendelian Populations
-
Wright S, (1931) Evolution in Mendelian Populations. Genetics 16: 97-159.
-
(1931)
Genetics
, vol.16
, pp. 97-159
-
-
Wright, S.1
-
21
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindor_ LA, et al. (2009) Finding the missing heritability of complex diseases. Nature 461: 747-53.
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindor-, L.A.5
-
22
-
-
62549085618
-
Human genetic variation and its contribution to complex traits
-
Frazer KA, Murray SS, Schork NJ, Topol EJ, (2009) Human genetic variation and its contribution to complex traits. Nature reviews Genetics 10: 241-51.
-
(2009)
Nature Reviews Genetics
, vol.10
, pp. 241-251
-
-
Frazer, K.A.1
Murray, S.S.2
Schork, N.J.3
Topol, E.J.4
-
23
-
-
77952557918
-
Missing heritability and strategies for finding the underlying causes of complex disease
-
Eichler EE, Flint J, Gibson G, Kong A, Leal SM, et al. (2010) Missing heritability and strategies for finding the underlying causes of complex disease. Nature reviews Genetics 11: 446-50.
-
(2010)
Nature Reviews Genetics
, vol.11
, pp. 446-450
-
-
Eichler, E.E.1
Flint, J.2
Gibson, G.3
Kong, A.4
Leal, S.M.5
-
25
-
-
40849097776
-
Heritability in the genomics era - concepts and misconceptions
-
Visscher PM, Hill WG, Wray NR, (2008) Heritability in the genomics era- concepts and misconceptions. Nature Reviews Genetics 9: 255-66.
-
(2008)
Nature Reviews Genetics
, vol.9
, pp. 255-266
-
-
Visscher, P.M.1
Hill, W.G.2
Wray, N.R.3
-
26
-
-
16844366786
-
Genome-wide strategies for detecting multiple loci that inuence complex diseases
-
Marchini J, Donnelly P, Cardon LR, (2005) Genome-wide strategies for detecting multiple loci that inuence complex diseases. Nat Genet 37: 413-417.
-
(2005)
Nat Genet
, vol.37
, pp. 413-417
-
-
Marchini, J.1
Donnelly, P.2
Cardon, L.R.3
-
27
-
-
33749388527
-
Two-Stage Two-Locus Models in Genome-Wide Association
-
doi: 10.1371/journal.pgen.0020157
-
Evans DM, Marchini J, Morris AP, Cardon LR, (2006) Two-Stage Two-Locus Models in Genome-Wide Association. PLoS Genet 2: e157 doi:10.1371/journal.pgen.0020157.
-
(2006)
PLoS Genet
, vol.2
-
-
Evans, D.M.1
Marchini, J.2
Morris, A.P.3
Cardon, L.R.4
-
28
-
-
40149087235
-
Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits
-
doi: 10.1371/journal.pgen.1000008
-
Hill WG, Goddard ME, Visscher PM, (2008) Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits. PLoS Genet 4: e1000008 doi:10.1371/journal.pgen.1000008.
-
(2008)
PLoS Genet
, vol.4
-
-
Hill, W.G.1
Goddard, M.E.2
Visscher, P.M.3
-
29
-
-
66849097781
-
Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture
-
doi: 10.1371/journal.pone.0005639
-
Greene CS, Penrod NM, Williams SM, Moore JH, (2009) Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture. PLoS ONE 4: e5639 doi:10.1371/journal.pone.0005639.
-
(2009)
PLoS ONE
, vol.4
-
-
Greene, C.S.1
Penrod, N.M.2
Williams, S.M.3
Moore, J.H.4
-
31
-
-
40149107330
-
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen
-
doi: 10.1371/journal.pgen.1000005
-
Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, et al. (2008) Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. PLoS Genet 4: e1000005 doi:10.1371/journal.pgen.1000005.
-
(2008)
PLoS Genet
, vol.4
-
-
Arnoldo, A.1
Curak, J.2
Kittanakom, S.3
Chevelev, I.4
Lee, V.T.5
-
33
-
-
69449106377
-
Robustness: mechanisms and consequences
-
Masel J, Siegal M, (2009) Robustness: mechanisms and consequences. Trends in Genetics 25: 395-403.
-
(2009)
Trends in Genetics
, vol.25
, pp. 395-403
-
-
Masel, J.1
Siegal, M.2
-
34
-
-
84867781208
-
Epistasis as the primary factor in molecular evolution
-
Breen MS, Kemena C, Vlasov PK, Notredame C, Kondrashov Fa, (2012) Epistasis as the primary factor in molecular evolution. Nature 490: 535-538.
-
(2012)
Nature
, vol.490
, pp. 535-538
-
-
Breen, M.S.1
Kemena, C.2
Vlasov, P.K.3
Notredame, C.4
Kondrashov, F.5
-
36
-
-
77954960062
-
Phenotypic robustness conferred by apparently redundant transcriptional enhancers
-
Frankel N, Davis GK, Vargas D, Wang S, Payre F, et al. (2010) Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature 466: 490-3.
-
(2010)
Nature
, vol.466
, pp. 490-493
-
-
Frankel, N.1
Davis, G.K.2
Vargas, D.3
Wang, S.4
Payre, F.5
-
38
-
-
78049347495
-
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
-
Strange A, Capon F, Spencer CCa, Knight J, Weale ME, et al. (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nature genetics 42: 985-90.
-
(2010)
Nature Genetics
, vol.42
, pp. 985-990
-
-
Strange, A.1
Capon, F.2
Spencer, C.C.3
Knight, J.4
Weale, M.E.5
-
39
-
-
79960899377
-
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
-
Evans DM, Spencer CCa, Pointon JJ, Su Z, Harvey D, et al. (2011) Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nature Genetics 43.
-
(2011)
Nature Genetics
, vol.43
-
-
Evans, D.M.1
Spencer, C.C.2
Pointon, J.J.3
Su, Z.4
Harvey, D.5
-
40
-
-
33645381715
-
Epistasis and the release of genetic variation during long-term selection
-
Carlborg O, Jacobsson L, Ahgren P, Siegel P, Andersson L, (2006) Epistasis and the release of genetic variation during long-term selection. Nat Genet 38: 418-420.
-
(2006)
Nat Genet
, vol.38
, pp. 418-420
-
-
Carlborg, O.1
Jacobsson, L.2
Ahgren, P.3
Siegel, P.4
Andersson, L.5
-
41
-
-
0032569851
-
Hsp90 as a capacitor for morphological evolution
-
Rutherford SL, Lindquist S, (1998) Hsp90 as a capacitor for morphological evolution. Nature 396: 336-342.
-
(1998)
Nature
, vol.396
, pp. 336-342
-
-
Rutherford, S.L.1
Lindquist, S.2
-
42
-
-
77649168145
-
The quantitative genetics of phenotypic robustness
-
doi: 10.1371/journal.pone.0008635
-
Fraser HB, Schadt EE, (2010) The quantitative genetics of phenotypic robustness. PLoS ONE 5: e8635 doi:10.1371/journal.pone.0008635.
-
(2010)
PLoS ONE
, vol.5
-
-
Fraser, H.B.1
Schadt, E.E.2
-
43
-
-
0037030713
-
Hsp90 as a capacitor of phenotypic variation
-
Queitsch C, Sangster TA, Lindquist S, (2002) Hsp90 as a capacitor of phenotypic variation. Nature 417: 618-624.
-
(2002)
Nature
, vol.417
, pp. 618-624
-
-
Queitsch, C.1
Sangster, T.A.2
Lindquist, S.3
-
44
-
-
0036155238
-
A perspective on epistasis: limits of models displaying no main effect
-
Culverhouse R, Suarez BK, Lin J, Reich T, (2002) A perspective on epistasis: limits of models displaying no main effect. American journal of human genetics 70: 461-71.
-
(2002)
American Journal of Human Genetics
, vol.70
, pp. 461-471
-
-
Culverhouse, R.1
Suarez, B.K.2
Lin, J.3
Reich, T.4
-
45
-
-
0001189920
-
A Model of a Genetic System which Leads to Closer Linkage by Natural Selection
-
Kimura M, (1956) A Model of a Genetic System which Leads to Closer Linkage by Natural Selection. Evolution 10: 278-287.
-
(1956)
Evolution
, vol.10
, pp. 278-287
-
-
Kimura, M.1
-
47
-
-
79957823590
-
EpiGPU: exhaustive pairwise epistasis scans parallelized on consumer level graphics cards
-
Hemani G, Theocharidis A, Wei W, Haley C, (2011) EpiGPU: exhaustive pairwise epistasis scans parallelized on consumer level graphics cards. Bioinformatics (Oxford, England) 27: 1462-5.
-
(2011)
Bioinformatics (Oxford, England)
, vol.27
, pp. 1462-1465
-
-
Hemani, G.1
Theocharidis, A.2
Wei, W.3
Haley, C.4
-
48
-
-
0033940280
-
A Complete Enumeration and Classification of Two-Locus Disease Models
-
Li W, Reich J, (2000) A Complete Enumeration and Classification of Two-Locus Disease Models. Human Heredity 50: 334-349.
-
(2000)
Human Heredity
, vol.50
, pp. 334-349
-
-
Li, W.1
Reich, J.2
-
49
-
-
84971185409
-
The correlation between relatives on the supposition of Mendelian inheritance
-
Fisher R, (1918) The correlation between relatives on the supposition of Mendelian inheritance. Transactions of the Royal Society of Edinburgh 52: 399-433.
-
(1918)
Transactions of the Royal Society of Edinburgh
, vol.52
, pp. 399-433
-
-
Fisher, R.1
-
52
-
-
0034845083
-
Overdominant epistatic loci are the primary genetic basis of inbreeding depression and heterosis in rice. II. Grain yield components
-
Luo LJ, Li ZK, Mei HW, Shu QY, Tabien R, et al. (2001) Overdominant epistatic loci are the primary genetic basis of inbreeding depression and heterosis in rice. II. Grain yield components. Genetics 158: 1755-71.
-
(2001)
Genetics
, vol.158
, pp. 1755-1771
-
-
Luo, L.J.1
Li, Z.K.2
Mei, H.W.3
Shu, Q.Y.4
Tabien, R.5
-
53
-
-
0001146515
-
The relationship of heterosis and genetic divergence in maize
-
Moll R, Lonnquist J, Fortuno J, Johnson E, (1965) The relationship of heterosis and genetic divergence in maize. Genetics 52: 139.
-
(1965)
Genetics
, vol.52
, pp. 139
-
-
Moll, R.1
Lonnquist, J.2
Fortuno, J.3
Johnson, E.4
-
54
-
-
0028114735
-
Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II
-
Chen C, Rainnie DG, Greene RW, Tonegawa S, (1994) Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science (New York, NY) 266: 291-4.
-
(1994)
Science (New York, NY)
, vol.266
, pp. 291-294
-
-
Chen, C.1
Rainnie, D.G.2
Greene, R.W.3
Tonegawa, S.4
-
55
-
-
0022523263
-
Molecular basis for heterosis for myelin basic protein content in mice
-
Miskimins R, Ebato H, Seyfried TN, Yu RK, (1986) Molecular basis for heterosis for myelin basic protein content in mice. Proceedings of the National Academy of Sciences of the United States of America 83: 1532-5.
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, pp. 1532-1535
-
-
Miskimins, R.1
Ebato, H.2
Seyfried, T.N.3
Yu, R.K.4
-
57
-
-
0028294555
-
Mullers ratchet under epistatic selection
-
Kondrashov A, (1994) Mullers ratchet under epistatic selection. Genetics 136: 1469.
-
(1994)
Genetics
, vol.136
, pp. 1469
-
-
Kondrashov, A.1
-
58
-
-
0029166841
-
Mullers Ratchet, Epistasis and Mutation Effects
-
Butcher D, (1995) Mullers Ratchet, Epistasis and Mutation Effects. Genetics 141: 431.
-
(1995)
Genetics
, vol.141
, pp. 431
-
-
Butcher, D.1
-
60
-
-
77957879688
-
Extreme evolutionary disparities seen in positive selection across seven complex diseases
-
doi: 10.1371/journal.pone.0012236
-
Corona E, Dudley JT, Butte AJ, (2010) Extreme evolutionary disparities seen in positive selection across seven complex diseases. PLoS ONE 5: e12236 doi:10.1371/journal.pone.0012236.
-
(2010)
PLoS ONE
, vol.5
-
-
Corona, E.1
Dudley, J.T.2
Butte, A.J.3
-
61
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke A, McGovern DPB, Barrett JC, Wang K, Radford-Smith GL, et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature genetics 42: 1118-25.
-
(2010)
Nature Genetics
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.B.2
Barrett, J.C.3
Wang, K.4
Radford-Smith, G.L.5
-
62
-
-
80053439315
-
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
-
doi: 10.1371/journal.pgen.1002293
-
Bradfield JP, Qu HQ, Wang K, Zhang H, Sleiman PM, et al. (2011) A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet 7: e1002293 doi:10.1371/journal.pgen.1002293.
-
(2011)
PLoS Genet
, vol.7
-
-
Bradfield, J.P.1
Qu, H.Q.2
Wang, K.3
Zhang, H.4
Sleiman, P.M.5
-
63
-
-
77956395423
-
BOOST: A Fast Approach to Detecting Gene- Gene Interactions in Genome-wide Case-Control Studies
-
Wan X, Yang C, Yang Q, Xue H, Fan X, et al. (2010) BOOST: A Fast Approach to Detecting Gene- Gene Interactions in Genome-wide Case-Control Studies. American journal of human genetics 87: 325-340.
-
(2010)
American Journal of Human Genetics
, vol.87
, pp. 325-340
-
-
Wan, X.1
Yang, C.2
Yang, Q.3
Xue, H.4
Fan, X.5
-
64
-
-
77954182718
-
TEAM: efficient two-locus epistasis tests in human genome-wide association study
-
Zhang X, Huang S, Zou F, Wang W, (2010) TEAM: efficient two-locus epistasis tests in human genome-wide association study. Bioinformatics 26: i217-i227.
-
(2010)
Bioinformatics
, vol.26
-
-
Zhang, X.1
Huang, S.2
Zou, F.3
Wang, W.4
-
65
-
-
79952740772
-
EPIBLASTERfast exhaustive two-locus epistasis detection strategy using graphical processing units
-
Kam-Thong T, Czamara D, Tsuda K, Borgwardt K, Lewis CM, et al. (2010) EPIBLASTERfast exhaustive two-locus epistasis detection strategy using graphical processing units. European Journal of Human Genetics 19: 465-471.
-
(2010)
European Journal of Human Genetics
, vol.19
, pp. 465-471
-
-
Kam-Thong, T.1
Czamara, D.2
Tsuda, K.3
Borgwardt, K.4
Lewis, C.M.5
-
66
-
-
77955715381
-
SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder
-
Hu X, Liu Q, Zhang Z, Li Z, Wang S, et al. (2010) SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder. Cell Research 20: 854-857.
-
(2010)
Cell Research
, vol.20
, pp. 854-857
-
-
Hu, X.1
Liu, Q.2
Zhang, Z.3
Li, Z.4
Wang, S.5
-
67
-
-
0000951097
-
The Evolutionary Dynamics of Complex Polymorphisms
-
Lewontin R, Kojima K, (1960) The Evolutionary Dynamics of Complex Polymorphisms. Evolution 14: 458-472.
-
(1960)
Evolution
, vol.14
, pp. 458-472
-
-
Lewontin, R.1
Kojima, K.2
-
68
-
-
0003751736
-
-
New York, New York, USA: Springer-Verlag, second edition
-
Ewens WJ (2004) Mathematical Population Genetics. New York, New York, USA: Springer-Verlag, second edition.
-
(2004)
Mathematical Population Genetics
-
-
Ewens, W.J.1
-
69
-
-
0343202493
-
Changes of mean fitness in random mating populations when epistasis and linkage are present
-
Kojima K, Kelleher T, (1961) Changes of mean fitness in random mating populations when epistasis and linkage are present. Genetics 46: 527.
-
(1961)
Genetics
, vol.46
, pp. 527
-
-
Kojima, K.1
Kelleher, T.2
-
70
-
-
0001405869
-
Attainment of Quasi Linkage Equilibrium When Gene Frequencies Are Changing by Natural Selection
-
Kimura M, (1965) Attainment of Quasi Linkage Equilibrium When Gene Frequencies Are Changing by Natural Selection. Genetics 52: 875-90.
-
(1965)
Genetics
, vol.52
, pp. 875-890
-
-
Kimura, M.1
-
71
-
-
34250718803
-
A Unified Model for Functional and Statistical Epistasis and Its Application in Quantitative Trait Loci Analysis
-
Alvarez-Castro JMJM, Carlborg O, (2007) A Unified Model for Functional and Statistical Epistasis and Its Application in Quantitative Trait Loci Analysis. Genetics 176: 1151-1167.
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(2007)
Genetics
, vol.176
, pp. 1151-1167
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Alvarez-Castro, J.M.J.M.1
Carlborg, O.2
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