Hypoxia Antagonizes Glucose Deprivation on Interleukin 6 Expression in an Akt Dependent, but HIF-1/2α Independent Manner

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Choi, Sung Ji ^a   Shin, Ik Jae ^b   Je, Kang Hoon ^b   Min, Eun Kyoung ^a   Kim, Eun Ji ^a   Kim, Hee Sun ^c   Choe, Senyon ^a   Kim, Dong Eog ^b   Lee, Dong Kun ^a  

^a Songdo Global University Campus   (South Korea)

^b Dongguk University Ilsan Hospital   (South Korea)

^c Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OXYGEN; PROTEIN KINASE B; THAPSIGARGIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HYPOGLYCEMIA; HYPOXIA; IL 6 GENE; MACROPHAGE; MICROGLIA; MONOCYTE; MOUSE; NEWBORN; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CULTURE TECHNIQUES; CELL HYPOXIA; GENE EXPRESSION REGULATION; GLUCOSE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-6; MACROPHAGES; MAP KINASE KINASE 4; MICE; MICROGLIA; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EID: 84874769007     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058662     Document Type: Article

References (46)

1. Suh SW, Hamby AM, Swanson RA, (2007) Hypoglycemia, brain energetics, and hypoglycemic neuronal death. Glia 55: 1280-1286.
2. McNay EC, Williamson A, McCrimmon RJ, Sherwin RS, (2006) Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia. Diabetes 55: 1088-1095.
3. Yamada KA, Rensing N, Izumi Y, De Erausquin GA, Gazit V, et al. (2004) Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation. Pediatr Res 55: 372-379.
4. Kraskiewicz H, FitzGerald U, (2011) InterfERing with endoplasmic reticulum stress. Trends Pharmacol Sci 33: 53-63.
5. Walter P, Ron D, (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086.
6. Xu C, Bailly-Maitre B, Reed JC, (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664.
7. Stutzmann GE, Mattson MP, (2011) Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease. Pharmacol Rev 63: 700-727.
8. Verkhratsky A, Rodriguez JJ, Parpura V, (2012) Calcium signalling in astroglia. Mol Cell Endocrinol 353: 45-56.
9. Denmeade SR, Isaacs JT, (2005) The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer. Cancer Biol Ther 4: 14-22.
10. Hotamisligil GS, (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917.
11. Peters LR, Raghavan M, (2011) Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells. J Immunol 187: 919-931.
12. Fougeray S, Bouvier N, Beaune P, Legendre C, Anglicheau D, et al. (2011) Metabolic stress promotes renal tubular inflammation by triggering the unfolded protein response. Cell Death Dis 2: e143.
13. Yamada K, Inagaki N, (2002) ATP-sensitive K(+) channels in the brain: sensors of hypoxic conditions. News Physiol Sci 17: 127-130.
14. Kim NG, Lee H, Son E, Kwon OY, Park JY, et al. (2003) Hypoxic induction of caspase-11/caspase-1/interleukin-1beta in brain microglia. Brain Res Mol Brain Res 114: 107-114.
15. Wang MJ, Huang HM, Hsieh SJ, Jeng KC, Kuo JS, (2001) Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation. J Neuroimmunol 112: 28-34.
16. Pan H, Wu X, (2012) Hypoxia attenuates inflammatory mediators production induced by Acanthamoeba via Toll-like receptor 4 signaling in human corneal epithelial cells. Biochem Biophys Res Commun 420: 685-691.
17. Fitzgerald JP, Nayak B, Shanmugasundaram K, Friedrichs W, Sudarshan S, et al. (2012) Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. PLoS One 7: e30712.
18. Olli K, Lahtinen S, Rautonen N, Tiihonen K (2012) Betaine reduces the expression of inflammatory adipokines caused by hypoxia in human adipocytes. Br J Nutr: 1-7.
19. Dendorfer U, Oettgen P, Libermann TA, (1994) Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol Cell Biol 14: 4443-4454.
20. Akira S, Kishimoto T, (1997) NF-IL6 and NF-kappa B in cytokine gene regulation. Adv Immunol 65: 1-46.
21. Faggioli L, Merola M, Hiscott J, Furia A, Monese R, et al. (1997) Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-gamma. Eur J Immunol 27: 3022-3030.
22. Kaluz S, Kaluzova M, Stanbridge EJ, (2008) Regulation of gene expression by hypoxia: integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element. Clin Chim Acta 395: 6-13.
23. Deguchi JO, Yamazaki H, Aikawa E, Aikawa M, (2009) Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages. Arterioscler Thromb Vasc Biol 29: 1664-1670.
24. Stansley B, Post J, Hensley K, (2012) A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease. J Neuroinflammation 9: 115.
25. Ishibashi N, Prokopenko O, Reuhl KR, Mirochnitchenko O, (2002) Inflammatory response and glutathione peroxidase in a model of stroke. J Immunol 168: 1926-1933.
26. Williams AJ, Dave JR, Tortella FC, (2006) Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration. Neurochem Int 49: 106-112.
27. Montero M, Lobaton CD, Moreno A, Alvarez J, (2002) A novel regulatory mechanism of the mitochondrial Ca2+ uniporter revealed by the p38 mitogen-activated protein kinase inhibitor SB202190. FASEB J 16: 1955-1957.
28. Beurel E, Jope RS, (2009) Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. J Neuroinflammation 6: 9.
29. Yenari MA, Kauppinen TM, Swanson RA, (2010) Microglial activation in stroke: therapeutic targets. Neurotherapeutics 7: 378-391.
30. Kitamura Y, Takata K, Inden M, Tsuchiya D, Yanagisawa D, et al. (2004) Intracerebroventricular injection of microglia protects against focal brain ischemia. J Pharmacol Sci 94: 203-206.
31. Imai F, Suzuki H, Oda J, Ninomiya T, Ono K, et al. (2007) Neuroprotective effect of exogenous microglia in global brain ischemia. J Cereb Blood Flow Metab 27: 488-500.
32. Lalancette-Hebert M, Gowing G, Simard A, Weng YC, Kriz J, (2007) Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J Neurosci 27: 2596-2605.
33. Eltzschig HK, Carmeliet P, (2011) Hypoxia and inflammation. N Engl J Med 364: 656-665.
34. Klausen T, Olsen NV, Poulsen TD, Richalet JP, Pedersen BK, (1997) Hypoxemia increases serum interleukin-6 in humans. Eur J Appl Physiol Occup Physiol 76: 480-482.
35. Urner M, Herrmann IK, Booy C, Roth-Z' Graggen B, Maggiorini M, et al. (2012) Effect of hypoxia and dexamethasone on inflammation and ion transporter function in pulmonary cells. Clin Exp Immunol 169: 119-128.
36. Dings J, Meixensberger J, Jager A, Roosen K, (1998) Clinical experience with 118 brain tissue oxygen partial pressure catheter probes. Neurosurgery 43: 1082-1095.
37. Whiteley W, Jackson C, Lewis S, Lowe G, Rumley A, et al. (2009) Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6. PLoS Med 6: e1000145.
38. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH, (2000) Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101: 1767-1772.
39. Hirota H, Kiyama H, Kishimoto T, Taga T, (1996) Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. J Exp Med 183: 2627-2634.
40. Ali C, Nicole O, Docagne F, Lesne S, MacKenzie ET, et al. (2000) Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain. J Cereb Blood Flow Metab 20: 956-966.
41. Maeda Y, Matsumoto M, Hori O, Kuwabara K, Ogawa S, et al. (1994) Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival. J Exp Med 180: 2297-2308.
42. Jung JE, Kim GS, Chan PH, (2011) Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. Stroke 42: 3574-3579.
43. Cortes-Vieyra R, Bravo-Patino A, Valdez-Alarcon JJ, Cajero Juarez M, Finlay BB, et al. (2012) Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens. J Inflamm (Lond) 9: 23.
44. Yuskaitis CJ, Jope RS, (2009) Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity. Cell Signal 21: 264-273.
45. Lee DK, Park EJ, Kim EK, Jin J, Kim JS, et al. (2012) Atorvastatin and Simvastatin, but not Pravastatin, Up-regulate LPS-Induced MMP-9 Expression in Macrophages by Regulating Phosphorylation of ERK and CREB. Cell Physiol Biochem 30: 499-511.
46. Illario M, Giardino-Torchia ML, Sankar U, Ribar TJ, Galgani M, et al. (2008) Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood 111: 723-731.