Enhancing Human Spermine Synthase Activity by Engineered Mutations

PLoS Computational Biology

Volumn 9, Issue 2, 2013, Pages

  Zhang, Zhe ^a   Zheng, Yueli ^a   Petukh, Margo ^a   Pegg, Anthony ^b   Ikeguchi, Yoshihiko ^c   Alexov, Emil ^a  

^a CLEMSON UNIVERSITY   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c JOSAI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DIMERS; DISEASES; HYDROGEN BONDS;

ACTIVE SITE; AMINO-ACIDS; FACIAL ASYMMETRY; IN-SILICO; MENTAL DISABILITIES; MOVEMENT DISORDERS; ROBINSON; SPERMIDINE; SYNTHASES; WILD TYPES;

VIBRATIONS (MECHANICAL);

DIMER; MONOMER; RECOMBINANT PROTEIN; SPERMIDINE; SPERMINE; SPERMINE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; BIOENGINEERING; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STABILITY; GENE; GENETIC VARIABILITY; IN VITRO STUDY; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; SMS GENE; STATIC ELECTRICITY; SYNDER ROBINSON SYNDROME; WILD TYPE; X CHROMOSOME LINKED DISORDER;

EID: 84874761289     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002924     Document Type: Article

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