메뉴 건너뛰기




Volumn 12, Issue 1, 2013, Pages 8-14

Alternative treatment options in colorectal cancer patients with 5-fluorouracil- or capecitabine-induced cardiotoxicity

Author keywords

Chemotherapy; Fluoropyrimidine induced toxicity; Raltitrexed; S 1

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CAPECITABINE; CETUXIMAB; CYTOCHROME P450 2A6; FLUOROURACIL; FOLINIC ACID; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; GLYCERYL TRINITRATE; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; RALTITREXED; UFT;

EID: 84874750769     PISSN: 15330028     EISSN: 19380674     Source Type: Journal    
DOI: 10.1016/j.clcc.2012.09.003     Document Type: Review
Times cited : (49)

References (78)
  • 1
    • 4644252335 scopus 로고    scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Un updated analysis [published erratum appears in J Clin Oncol 2005;23:1377-8]
    • P. Thirion, S. Michiels, J.P. Pignon Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: un updated analysis [published erratum appears in J Clin Oncol 2005;23:1377-8] J Clin Oncol 22 2004 3766 3775
    • (2004) J Clin Oncol , vol.22 , pp. 3766-3775
    • Thirion, P.1    Michiels, S.2    Pignon, J.P.3
  • 2
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer Meta-analysis Group in Cancer
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer Meta-analysis Group In Cancer J Clin Oncol 16 1998 301 308
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 3
    • 34247493038 scopus 로고    scopus 로고
    • Efficacy and safety of capecitabine for colorectal cancer
    • E. Chu, C. Eng, J. Abbruzzese et al. Efficacy and safety of capecitabine for colorectal cancer Am J Oncol Rev 2 suppl 3 2003 1 28
    • (2003) Am J Oncol Rev , vol.2 , Issue.SUPPL. 3 , pp. 1-28
    • Chu, E.1    Eng, C.2    Abbruzzese, J.3
  • 4
    • 42949150908 scopus 로고    scopus 로고
    • Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer
    • J. Cassidy, S. Clarke, E. Díaz-Rubio Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer J Clin Oncol 26 2008 2006 2012
    • (2008) J Clin Oncol , vol.26 , pp. 2006-2012
    • Cassidy, J.1    Clarke, S.2    Díaz-Rubio, E.3
  • 5
    • 35848950726 scopus 로고    scopus 로고
    • Cardiotoxicity of fluoropyrimidines in different schedules of administration: A prospective study
    • C. Kosmas, M.S. Kallistratos, P. Kopterides Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study J Cancer Res Clin Oncol 134 2008 75 82
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 75-82
    • Kosmas, C.1    Kallistratos, M.S.2    Kopterides, P.3
  • 6
    • 0027069532 scopus 로고
    • Cardiotoxicity of high-dose continuous infusion fluorouracil: A prospective clinical study
    • M. de Forni, M.C. Malet-Martino, P. Jaillais Cardiotoxicity of high-dose continuous infusion fluorouracil: a prospective clinical study J Clin Oncol 10 1992 1795 1801
    • (1992) J Clin Oncol , vol.10 , pp. 1795-1801
    • De Forni, M.1    Malet-Martino, M.C.2    Jaillais, P.3
  • 7
    • 0027496323 scopus 로고
    • Symptomatic cardiotoxicity with high-dose 5-fluorouracil infusion: A prospective study
    • S.S. Akhtar, K.P. Salim, Z.A. Bano Symptomatic cardiotoxicity with high-dose 5-fluorouracil infusion: a prospective study Oncology 50 1993 441 444
    • (1993) Oncology , vol.50 , pp. 441-444
    • Akhtar, S.S.1    Salim, K.P.2    Bano, Z.A.3
  • 8
    • 22144479717 scopus 로고    scopus 로고
    • The frequency and pattern of cardiotoxicity observed with capecitabine used in conjunction with oxaliplatin in patients treated for advanced colorectal cancer (CRC)
    • M. Ng, D. Cunningham, A.R. Norman The frequency and pattern of cardiotoxicity observed with capecitabine used in conjunction with oxaliplatin in patients treated for advanced colorectal cancer (CRC) Eur J Cancer 41 2005 1542 1546
    • (2005) Eur J Cancer , vol.41 , pp. 1542-1546
    • Ng, M.1    Cunningham, D.2    Norman, A.R.3
  • 9
    • 0020307773 scopus 로고
    • Cardiac toxicity of 5-fluorouracil: A study on 1083 patients
    • R. Labianca, G. Beretta, M. Clerici Cardiac toxicity of 5-fluorouracil: a study on 1083 patients Tumori 68 1982 505 510
    • (1982) Tumori , vol.68 , pp. 505-510
    • Labianca, R.1    Beretta, G.2    Clerici, M.3
  • 10
    • 0027295441 scopus 로고
    • Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer
    • C. Schöber, E. Papageorgiou, A. Harstrick Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer Cancer 72 1993 2242 2247
    • (1993) Cancer , vol.72 , pp. 2242-2247
    • Schöber, C.1    Papageorgiou, E.2    Harstrick, A.3
  • 11
    • 21744461901 scopus 로고    scopus 로고
    • Cardiotoxicity of de Gramont's regimen: Incidence, clinical characteristics and long-term follow-up
    • N. Meydan, I. Kundak, T. Yavuzsen Cardiotoxicity of de Gramont's regimen: incidence, clinical characteristics and long-term follow-up Jpn J Clin Oncol 35 2005 265 270
    • (2005) Jpn J Clin Oncol , vol.35 , pp. 265-270
    • Meydan, N.1    Kundak, I.2    Yavuzsen, T.3
  • 12
    • 79951907915 scopus 로고    scopus 로고
    • Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle
    • S.A. Jensen, P. Hasbak, J. Mortensen Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle J Clin Oncol 28 2010 5280 5286
    • (2010) J Clin Oncol , vol.28 , pp. 5280-5286
    • Jensen, S.A.1    Hasbak, P.2    Mortensen, J.3
  • 13
    • 0036018917 scopus 로고    scopus 로고
    • Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with 5-fluorouracil
    • E. Van Cutsem, P.M. Hoff, J.L. Blum Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with 5-fluorouracil Ann Oncol 13 2002 484 485
    • (2002) Ann Oncol , vol.13 , pp. 484-485
    • Van Cutsem, E.1    Hoff, P.M.2    Blum, J.L.3
  • 14
    • 38949174220 scopus 로고    scopus 로고
    • Capecitabine-related cardiotoxicity: Recognition and management
    • M.W. Saif, M. Tomita, L. Ledbetter Capecitabine-related cardiotoxicity: recognition and management J Support Oncol 6 2008 41 48
    • (2008) J Support Oncol , vol.6 , pp. 41-48
    • Saif, M.W.1    Tomita, M.2    Ledbetter, L.3
  • 16
    • 0027472160 scopus 로고
    • The syndrome of 5-fluorouracil cardiotoxicity An elusive cardiopathy
    • N.C. Robben, A.W. Pippas, J.O. Moore The syndrome of 5-fluorouracil cardiotoxicity An elusive cardiopathy Cancer 71 1993 493 499
    • (1993) Cancer , vol.71 , pp. 493-499
    • Robben, N.C.1    Pippas, A.W.2    Moore, J.O.3
  • 17
    • 33745712231 scopus 로고    scopus 로고
    • Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine
    • S.A. Jensen, J.B. Sørensen Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine Cancer Chemother Pharmacol 58 2006 487 493
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 487-493
    • Jensen, S.A.1    Sørensen, J.B.2
  • 18
    • 18144444456 scopus 로고    scopus 로고
    • 5-Fluorouracil induces arterial vasocontractions
    • T. Südhoff, M.D. Enderle, M. Pahlke 5-Fluorouracil induces arterial vasocontractions Ann Oncol 15 2004 661 664
    • (2004) Ann Oncol , vol.15 , pp. 661-664
    • Südhoff, T.1    Enderle, M.D.2    Pahlke, M.3
  • 19
    • 0023254077 scopus 로고
    • 5-Fluorouracil-induced coronary vasospasm
    • A.J. Burger, S. Mannino 5-Fluorouracil-induced coronary vasospasm Am Heart J 114 1987 433 436
    • (1987) Am Heart J , vol.114 , pp. 433-436
    • Burger, A.J.1    Mannino, S.2
  • 20
    • 0029000460 scopus 로고
    • A case of 5-fluorouracil cardiotoxicity simulating acute myocardial infarction
    • Y. Mizuno, Y. Hokamura, T. Kimura A case of 5-fluorouracil cardiotoxicity simulating acute myocardial infarction Jpn Circ J 59 1995 303 307
    • (1995) Jpn Circ J , vol.59 , pp. 303-307
    • Mizuno, Y.1    Hokamura, Y.2    Kimura, T.3
  • 21
    • 66949158016 scopus 로고    scopus 로고
    • Fluoropyrimidine-associated cardiotoxicity: Revisited
    • M.W. Saif, M.M. Shah, A.R. Shah Fluoropyrimidine-associated cardiotoxicity: revisited Expert Opin Drug Saf 8 2009 191 202
    • (2009) Expert Opin Drug Saf , vol.8 , pp. 191-202
    • Saif, M.W.1    Shah, M.M.2    Shah, A.R.3
  • 22
    • 84856757864 scopus 로고    scopus 로고
    • 5-Fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity
    • S.A. Jensen, J.B. Sørensen 5-Fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity Cancer Chemother Pharmacol 69 2012 57 64
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 57-64
    • Jensen, S.A.1    Sørensen, J.B.2
  • 23
    • 33745985405 scopus 로고    scopus 로고
    • Cardiac lesions induced by 5-fluorouracil in the rabbit
    • P. Tsibiribi, C. Bui-Xuan, B. Bui-Xuan Cardiac lesions induced by 5-fluorouracil in the rabbit Hum Exp Toxicol 25 2006 305 309
    • (2006) Hum Exp Toxicol , vol.25 , pp. 305-309
    • Tsibiribi, P.1    Bui-Xuan, C.2    Bui-Xuan, B.3
  • 24
    • 0023567901 scopus 로고
    • 5-Fluorouracil cardiotoxicity: Left ventricular dysfunction and effect of coronary vasodilators
    • B. Patel, R.A. Kloner, J. Ensley 5-Fluorouracil cardiotoxicity: left ventricular dysfunction and effect of coronary vasodilators Am J Med Sci 294 1987 238 243
    • (1987) Am J Med Sci , vol.294 , pp. 238-243
    • Patel, B.1    Kloner, R.A.2    Ensley, J.3
  • 25
    • 6844251612 scopus 로고    scopus 로고
    • The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate
    • M. Arellano, M. Malet-Martino, R. Martino The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate Br J Cancer 77 1998 79 86
    • (1998) Br J Cancer , vol.77 , pp. 79-86
    • Arellano, M.1    Malet-Martino, M.2    Martino, R.3
  • 27
    • 0019298802 scopus 로고
    • Cardiotoxic effects of 5-fluorouracil in the guinea pig
    • I. Matsubara, J. Kamiya, S. Imai Cardiotoxic effects of 5-fluorouracil in the guinea pig Jpn J Pharmacol 30 1980 871 879
    • (1980) Jpn J Pharmacol , vol.30 , pp. 871-879
    • Matsubara, I.1    Kamiya, J.2    Imai, S.3
  • 28
    • 70350072614 scopus 로고    scopus 로고
    • Bolus 5-fluorouracil as an alternative modality to infusion 5-fluorouracil in a patient with rectal cancer and capecitabine-induced cardiotoxicity
    • W. Shaib, V. Lee, M.W. Saif Bolus 5-fluorouracil as an alternative modality to infusion 5-fluorouracil in a patient with rectal cancer and capecitabine-induced cardiotoxicity In Vivo 23 2009 821 826
    • (2009) Vivo , vol.23 , pp. 821-826
    • Shaib, W.1    Lee, V.2    Saif, M.W.3
  • 29
    • 77951096208 scopus 로고    scopus 로고
    • Cardiotoxicity with 5-fluorouracil and capecitabine: More than just vasospastic angina
    • T. Stewart, N. Pavlakis, M. Ward Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina Intern Med J 40 2010 303 307
    • (2010) Intern Med J , vol.40 , pp. 303-307
    • Stewart, T.1    Pavlakis, N.2    Ward, M.3
  • 30
    • 61349139283 scopus 로고    scopus 로고
    • Coronary vasospasm with myocardial stunning in a patient with colon cancer receiving adjuvant chemotherapy with FOLFOX regimen
    • J. Cerny, A. Hassan, C. Smith Coronary vasospasm with myocardial stunning in a patient with colon cancer receiving adjuvant chemotherapy with FOLFOX regimen Clin Colorectal Cancer 8 2009 55 58
    • (2009) Clin Colorectal Cancer , vol.8 , pp. 55-58
    • Cerny, J.1    Hassan, A.2    Smith, C.3
  • 31
    • 0038456044 scopus 로고    scopus 로고
    • Prophylactic options in patients with 5-fluorouracil-associated cardiotoxicity
    • G. Cianci, M.F. Morelli, K. Cannita Prophylactic options in patients with 5-fluorouracil-associated cardiotoxicity Br J Cancer 88 2003 1507 1509
    • (2003) Br J Cancer , vol.88 , pp. 1507-1509
    • Cianci, G.1    Morelli, M.F.2    Cannita, K.3
  • 32
    • 0021336543 scopus 로고
    • Effect of coadministration of uracil on the toxicity of tegafur
    • J. Yamamoto, A. Haruno, Y. Yoshimura Effect of coadministration of uracil on the toxicity of tegafur J Pharm Sci 73 1984 212 214
    • (1984) J Pharm Sci , vol.73 , pp. 212-214
    • Yamamoto, J.1    Haruno, A.2    Yoshimura, Y.3
  • 33
    • 0038350310 scopus 로고    scopus 로고
    • A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies
    • D. Yip, C. Karapetis, A.H. Strickland A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies Ann Oncol 14 2003 864 866
    • (2003) Ann Oncol , vol.14 , pp. 864-866
    • Yip, D.1    Karapetis, C.2    Strickland, A.H.3
  • 34
    • 0042671111 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule
    • X.D. Guo, N. Harold, M.W. Saif Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule Cancer Chemother Pharmacol 52 2003 79 85
    • (2003) Cancer Chemother Pharmacol , vol.52 , pp. 79-85
    • Guo, X.D.1    Harold, N.2    Saif, M.W.3
  • 35
    • 0036018890 scopus 로고    scopus 로고
    • Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer
    • J.C. Marsh, P. Catalano, J. Huang Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer Clin Colorectal Cancer 2 2002 43 50
    • (2002) Clin Colorectal Cancer , vol.2 , pp. 43-50
    • Marsh, J.C.1    Catalano, P.2    Huang, J.3
  • 37
    • 0036731818 scopus 로고    scopus 로고
    • Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • J.Y. Douillard, P.M. Hoff, J.R. Skillings Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 2002 3605 3616
    • (2002) J Clin Oncol , vol.20 , pp. 3605-3616
    • Douillard, J.Y.1    Hoff, P.M.2    Skillings, J.R.3
  • 38
    • 33646443236 scopus 로고    scopus 로고
    • Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel project Protocol C-06
    • B.C. Lembersky, H.S. Wieand, N.J. Petrelli Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel project Protocol C-06 J Clin Oncol 24 2006 2059 2064
    • (2006) J Clin Oncol , vol.24 , pp. 2059-2064
    • Lembersky, B.C.1    Wieand, H.S.2    Petrelli, N.J.3
  • 39
    • 4444243813 scopus 로고    scopus 로고
    • Comparison of the efficacy, toxicity and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: Joint United States and Japan study of UFT/LV
    • K. Shirao, P.M. Hoff, A. Ohtsu Comparison of the efficacy, toxicity and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV J Clin Oncol 22 2004 3466 3474
    • (2004) J Clin Oncol , vol.22 , pp. 3466-3474
    • Shirao, K.1    Hoff, P.M.2    Ohtsu, A.3
  • 40
    • 84898693009 scopus 로고    scopus 로고
    • Potential regional differences for the tolerability profiles of fluoropyrimidines
    • D.G. Haller, J. Cassidy, S.J. Clarke Potential regional differences for the tolerability profiles of fluoropyrimidines J Clin Oncol 24 2008 2059 2064
    • (2008) J Clin Oncol , vol.24 , pp. 2059-2064
    • Haller, D.G.1    Cassidy, J.2    Clarke, S.J.3
  • 41
    • 62449253891 scopus 로고    scopus 로고
    • The role of UFT in metastatic colorectal cancer
    • J. Bennouna, M. Saunders, J.Y. Douillard The role of UFT in metastatic colorectal cancer Oncology 76 2009 301 310
    • (2009) Oncology , vol.76 , pp. 301-310
    • Bennouna, J.1    Saunders, M.2    Douillard, J.Y.3
  • 42
    • 84898698682 scopus 로고    scopus 로고
    • Vasospasm after chemotherapy with 5-fluorouracil [in Spanish]
    • M. Sellés, P. Castellano, B. Zomora Vasospasm after chemotherapy with 5-fluorouracil [in Spanish] An Med Int 18 2001 2
    • (2001) An Med Int , vol.18 , pp. 2
    • Sellés, M.1    Castellano, P.2    Zomora, B.3
  • 43
    • 77956150646 scopus 로고    scopus 로고
    • Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: A randomised phase 2/3 non-inferiority study (FIRIS study)
    • K. Muro, N. Boku, Y. Shimada Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study) Lancet Oncol 11 2010 853 860
    • (2010) Lancet Oncol , vol.11 , pp. 853-860
    • Muro, K.1    Boku, N.2    Shimada, Y.3
  • 44
    • 80054879369 scopus 로고    scopus 로고
    • A randomized phase III study of SOX (S-1/oxaliplatin) versus COX (capecitabine/oxaliplatin) in patients with advanced colorectal cancer
    • abstr 3524
    • Y.S. Park, H.J. Lim, J. Lee A randomized phase III study of SOX (S-1/oxaliplatin) versus COX (capecitabine/oxaliplatin) in patients with advanced colorectal cancer J Clin Oncol 29 Suppl 2011 abstr 3524
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Park, Y.S.1    Lim, H.J.2    Lee, J.3
  • 46
    • 0037430037 scopus 로고    scopus 로고
    • EORTC early clinical studies group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer
    • J. Van den Brande, P. Schöffski, J.H. Schellens EORTC early clinical studies group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer Br J Cancer 88 2003 648 653
    • (2003) Br J Cancer , vol.88 , pp. 648-653
    • Van Den Brande, J.1    Schöffski, P.2    Schellens, J.H.3
  • 47
    • 0041903833 scopus 로고    scopus 로고
    • Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors
    • G.J. Peters, P. Noordhuis, A.B. Van Kuilenburg Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors Cancer Chemother Pharmacol 52 2003 1 12
    • (2003) Cancer Chemother Pharmacol , vol.52 , pp. 1-12
    • Peters, G.J.1    Noordhuis, P.2    Van Kuilenburg, A.B.3
  • 48
    • 0141841803 scopus 로고    scopus 로고
    • Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil
    • Y. Yamada, T. Hamaguchi, M. Goto Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil Br J Cancer 89 2003 816 820
    • (2003) Br J Cancer , vol.89 , pp. 816-820
    • Yamada, Y.1    Hamaguchi, T.2    Goto, M.3
  • 49
    • 14444280873 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients
    • B. Reigner, J. Verweij, L. Dirix Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients Clin Cancer Res 4 1998 941 948
    • (1998) Clin Cancer Res , vol.4 , pp. 941-948
    • Reigner, B.1    Verweij, J.2    Dirix, L.3
  • 50
    • 29244485405 scopus 로고    scopus 로고
    • 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine
    • K. Muneoka, Y. Shirai, N. Yokoyama 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine Int J Clin Oncol 10 2005 441 443
    • (2005) Int J Clin Oncol , vol.10 , pp. 441-443
    • Muneoka, K.1    Shirai, Y.2    Yokoyama, N.3
  • 51
    • 0031915084 scopus 로고    scopus 로고
    • Raltitrexed A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer
    • N.S. Gunasekara, D. Faulds Raltitrexed A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer Drugs 55 1998 423 435
    • (1998) Drugs , vol.55 , pp. 423-435
    • Gunasekara, N.S.1    Faulds, D.2
  • 52
    • 53349162393 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1)
    • I. Popov, A. Carrato, A. Sobrero Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1) Eur J Cancer 44 2008 2204 2211
    • (2008) Eur J Cancer , vol.44 , pp. 2204-2211
    • Popov, I.1    Carrato, A.2    Sobrero, A.3
  • 53
    • 5544237608 scopus 로고    scopus 로고
    • Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer "tomudex" Colorectal Cancer Study Group [published erratum appears in: Ann Oncol 1997;8:407]
    • D. Cunningham, J. Zalcberg, U. Rath Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer "Tomudex" Colorectal Cancer Study Group [published erratum appears in: Ann Oncol 1997;8:407] Ann Oncol 7 1996 961 965
    • (1996) Ann Oncol , vol.7 , pp. 961-965
    • Cunningham, D.1    Zalcberg, J.2    Rath, U.3
  • 54
    • 0031671255 scopus 로고    scopus 로고
    • Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer Tomudex Colorectal Cancer Study Group
    • G. Cocconi, D. Cunningham, E. Van Cutsem Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer Tomudex Colorectal Cancer Study Group J Clin Oncol 16 1998 2943 2952
    • (1998) J Clin Oncol , vol.16 , pp. 2943-2952
    • Cocconi, G.1    Cunningham, D.2    Van Cutsem, E.3
  • 55
    • 0000269364 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex) versus 5-fluorouracil and leucovorin (5- FU+LV) in patients with advanced colorectal cancer (ACC): Results of a randomized multicenter, North American trial
    • Abstract 801
    • R. Pazdur, M. Vincent Raltitrexed (Tomudex) versus 5-fluorouracil and leucovorin (5- FU+LV) in patients with advanced colorectal cancer (ACC): results of a randomized multicenter, North American trial Proc Am Soc Clin Oncol 1997 Abstract 801
    • (1997) Proc Am Soc Clin Oncol
    • Pazdur, R.1    Vincent, M.2
  • 56
    • 0037018765 scopus 로고    scopus 로고
    • Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: A multicentre randomised trial
    • T.S. Maughan, R.D. James, D.J. Kerr Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial Lancet 359 2002 1555 1563
    • (2002) Lancet , vol.359 , pp. 1555-1563
    • Maughan, T.S.1    James, R.D.2    Kerr, D.J.3
  • 57
    • 0030823834 scopus 로고    scopus 로고
    • Overview of the tolerability of 'Tomudex' (raltitrexed): Collective clinical experience in advanced colorectal cancer
    • J. Zalcberg Overview of the tolerability of 'Tomudex' (raltitrexed): collective clinical experience in advanced colorectal cancer Anti Cancer Drugs 8 Suppl 2 1997 S17 S22
    • (1997) Anti Cancer Drugs , vol.8 , Issue.SUPPL. 2
    • Zalcberg, J.1
  • 58
    • 0033067452 scopus 로고    scopus 로고
    • The use of raltitrexed (Tomudex) in a patient with 5-FU induced myocardial ischaemia
    • C. Nutting, A. Folkes The use of raltitrexed (Tomudex) in a patient with 5-FU induced myocardial ischaemia J Clin Oncol 11 1999 66
    • (1999) J Clin Oncol , vol.11 , pp. 66
    • Nutting, C.1    Folkes, A.2
  • 59
    • 0031888945 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex): An alternative drug for patients with colorectal cancer and 5-FU
    • C.H. Köhne, P. Thuss-Patience, M. Friedrich Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-FU Br J Cancer 77 1998 973 977
    • (1998) Br J Cancer , vol.77 , pp. 973-977
    • Köhne, C.H.1    Thuss-Patience, P.2    Friedrich, M.3
  • 60
    • 84874705664 scopus 로고    scopus 로고
    • TOMOX compared to FOLFOX 4 as first-line treatment in patients with advanced colorectal cancer (ACRC): Results of a multicenter randomised phase II trial
    • JUNE ASCO Annual Meeting Proceedings Abstract 3563
    • C. Gravalos, C. Garcia-Giron, A. Salud TOMOX compared to FOLFOX 4 as first-line treatment in patients with advanced colorectal cancer (ACRC): results of a multicenter randomised phase II trial ASCO Annual Meeting Proceedings J Clin Oncol 23 June 1 Supplement 2005 Abstract 3563
    • (2005) J Clin Oncol , vol.23 , Issue.1 SUPPL.
    • Gravalos, C.1    Garcia-Giron, C.2    Salud, A.3
  • 61
    • 0034988578 scopus 로고    scopus 로고
    • Second-line treatment with oxaliplatin + raltitrexed in patients with advanced colorectal cancer failing fluoropyrimidine/leucovorin-based chemotherapy
    • W. Scheithauer, G.V. Kornek, B. Schuell Second-line treatment with oxaliplatin + raltitrexed in patients with advanced colorectal cancer failing fluoropyrimidine/leucovorin-based chemotherapy Ann Oncol 12 2001 709 714
    • (2001) Ann Oncol , vol.12 , pp. 709-714
    • Scheithauer, W.1    Kornek, G.V.2    Schuell, B.3
  • 62
    • 2442604628 scopus 로고    scopus 로고
    • Activity and toxicity of oxaliplatin plus raltitrexed in 5-fluorouracil refractory metastatic colorectal adeno-carcinoma
    • A. Laudani, V. Gebbia, V. Leonardi Activity and toxicity of oxaliplatin plus raltitrexed in 5-fluorouracil refractory metastatic colorectal adeno-carcinoma Anticancer Res 24 2004 1139 1142
    • (2004) Anticancer Res , vol.24 , pp. 1139-1142
    • Laudani, A.1    Gebbia, V.2    Leonardi, V.3
  • 63
    • 36849050218 scopus 로고    scopus 로고
    • Adjuvant therapy with raltitrexed in patients with colorectal cancer intolerant of 5-fluorouracil: British Columbia Cancer Agency experience
    • K.S. Wilson, C.A. Fitzgerald, J.B. Barnett Adjuvant therapy with raltitrexed in patients with colorectal cancer intolerant of 5-fluorouracil: British Columbia Cancer Agency experience Cancer Invest 25 2007 711 714
    • (2007) Cancer Invest , vol.25 , pp. 711-714
    • Wilson, K.S.1    Fitzgerald, C.A.2    Barnett, J.B.3
  • 64
    • 0036739135 scopus 로고    scopus 로고
    • Irinotecan and raltitrexed: An active combination in advanced colorectal cancer
    • C. Carnaghi, L. Rimassa, I. Garassino Irinotecan and raltitrexed: an active combination in advanced colorectal cancer Ann Oncol 13 2002 1424 1429
    • (2002) Ann Oncol , vol.13 , pp. 1424-1429
    • Carnaghi, C.1    Rimassa, L.2    Garassino, I.3
  • 65
    • 2442456768 scopus 로고    scopus 로고
    • Irinotecan plus raltitrexed as first-line treatment in advanced colorectal cancer: A phase II study
    • J. Feliu, A. Salud, P. Escudero Irinotecan plus raltitrexed as first-line treatment in advanced colorectal cancer: a phase II study Br J Cancer 90 2004 1502 1507
    • (2004) Br J Cancer , vol.90 , pp. 1502-1507
    • Feliu, J.1    Salud, A.2    Escudero, P.3
  • 66
    • 27944435401 scopus 로고    scopus 로고
    • Phase II randomised trial of raltitrexed-oxaliplatin vs raltitrexed-irinotecan as first-line treatment in advanced colorectal cancer
    • J. Feliu, C. Castañón, A. Salud Phase II randomised trial of raltitrexed-oxaliplatin vs raltitrexed-irinotecan as first-line treatment in advanced colorectal cancer Br J Cancer 93 2005 1230 1235
    • (2005) Br J Cancer , vol.93 , pp. 1230-1235
    • Feliu, J.1    Castañón, C.2    Salud, A.3
  • 67
    • 0042701930 scopus 로고    scopus 로고
    • Multicenter phase II trial evaluating a three-weekly schedule of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer
    • J. Aparicio, J.M. Vicent, I. Maestu Multicenter phase II trial evaluating a three-weekly schedule of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer Ann Oncol 14 2003 1121 1125
    • (2003) Ann Oncol , vol.14 , pp. 1121-1125
    • Aparicio, J.1    Vicent, J.M.2    Maestu, I.3
  • 68
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer Irinotecan Study Group
    • L.B. Saltz, J.V. Cox, C. Blanke Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer Irinotecan Study Group N Engl J Med 343 2000 905 914
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 69
    • 0037364658 scopus 로고    scopus 로고
    • Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer
    • C.S. Fuchs, M.R. Moore, G. Harker Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer J Clin Oncol 21 2003 807 814
    • (2003) J Clin Oncol , vol.21 , pp. 807-814
    • Fuchs, C.S.1    Moore, M.R.2    Harker, G.3
  • 70
    • 77955229256 scopus 로고    scopus 로고
    • Systematic review of benefits and risks of second-line irinotecan monotherapy for advanced colorectal cancer
    • L.J. Oostendorp, P.F. Stalmeier, P.C. Pasker-de Jong Systematic review of benefits and risks of second-line irinotecan monotherapy for advanced colorectal cancer Anticancer Drugs 21 2010 749 758
    • (2010) Anticancer Drugs , vol.21 , pp. 749-758
    • Oostendorp, L.J.1    Stalmeier, P.F.2    Pasker-De Jong, P.C.3
  • 71
    • 20244385592 scopus 로고    scopus 로고
    • Optimisation of irinotecan dose in the treatment of patients with metastatic colorectal cancer after 5-FU failure: Results from a multinational, randomised phase II study
    • E. Van Cutsem, L. Dirix, J.L. Van Laethem Optimisation of irinotecan dose in the treatment of patients with metastatic colorectal cancer after 5-FU failure: results from a multinational, randomised phase II study Br J Cancer 92 2005 1055 1062
    • (2005) Br J Cancer , vol.92 , pp. 1055-1062
    • Van Cutsem, E.1    Dirix, L.2    Van Laethem, J.L.3
  • 72
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • D. Cunningham, Y. Humblet, S. Siena Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer N Engl J Med 351 2004 337 345
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 73
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • A.F. Sobrero, J. Maurel, L. Fehrenbacher EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer J Clin Oncol 26 2008 2311 2319
    • (2008) J Clin Oncol , vol.26 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 74
    • 34547097252 scopus 로고    scopus 로고
    • Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX): Intergroup trial N9741 in first-line treatment of metastatic colorectal cancer
    • A.C. Ashley, D.J. Sargent, S.R. Alberts Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX): intergroup trial N9741 in first-line treatment of metastatic colorectal cancer Cancer 110 2007 670 677
    • (2007) Cancer , vol.110 , pp. 670-677
    • Ashley, A.C.1    Sargent, D.J.2    Alberts, S.R.3
  • 75
    • 78650683300 scopus 로고    scopus 로고
    • Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxaliplatin as first-line treatment of advanced colorectal cancer
    • L. Fischer von Weikersthal, A. Schalhorn, M. Stauch Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxaliplatin as first-line treatment of advanced colorectal cancer Eur J Cancer 47 2011 206 214
    • (2011) Eur J Cancer , vol.47 , pp. 206-214
    • Fischer Von Weikersthal, L.1    Schalhorn, A.2    Stauch, M.3
  • 76
    • 53749092781 scopus 로고    scopus 로고
    • Oxaliplatin plus irinotecan compared with irinotecan alone as second-line treatment after single-agent fluoropyrimidine therapy for metastatic colorectal carcinoma
    • D. Haller, M. Rothenberg, A. Wong Oxaliplatin plus irinotecan compared with irinotecan alone as second-line treatment after single-agent fluoropyrimidine therapy for metastatic colorectal carcinoma J Clin Oncol 26 2008 4544 4550
    • (2008) J Clin Oncol , vol.26 , pp. 4544-4550
    • Haller, D.1    Rothenberg, M.2    Wong, A.3
  • 78
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
    • E. Van Cutsem, M. Peeters, S. Siena Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer J Clin Oncol 25 2007 1658 1664
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.