Narirutin fraction from citrus peels attenuates alcoholic liver disease in mice

Food and Chemical Toxicology

Volumn 55, Issue , 2013, Pages 637-644

  Park, Ho Young ^a   Ha, Sang Keun ^a   Eom, Hyojin ^a   Choi, Inwook ^a  

^a Korea Food Research Institute   (South Korea)

Author keywords

Alcoholic liver disease; Citrus unshiu; Inflammation; Narirutin; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MALONALDEHYDE; NARIRUTIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL DEGENERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER NECROSIS; LIVER PROTECTION; LIVER WEIGHT; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PROTEIN LOCALIZATION; UPREGULATION;

ANIMALS; BODY WEIGHT; CITRUS; DISACCHARIDES; FLAVANONES; GLUTATHIONE; INTERLEUKIN-1BETA; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED ICR; NF-KAPPA B; ORGAN SIZE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84874705542     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.01.060     Document Type: Article

References (32)

1. Albano E. Alcohol, oxidative stress and free radical damage. Proc. Nutr. Soc. 2006, 65:278-290.
2. Anna Mae D. Liver disease in alcohol abusers: clinical perspective. Alcohol 2002, 27:7-11.
3. Baillie M. Alcohol and the liver. Gut 1971, 12:222-229.
4. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37:911-917.
5. Brooks P.J. DNA damage, DNA repair, and alcohol toxicity - a review. Alcohol. Clin. Exp. Res. 1997, 21:1073-1082.
6. Chen X. Protective effects of quercetin on liver injury induced by ethanol. Pharmacogn. Mag. 2010, 6:135-141.
7. Clewer A.G., Scarisbrick D.H. Practical Statistics and Experimental Design for Plant and Crop Science 2001, John Wiley & Sons Ltd., Chichester.
8. Comporti M. Glutathione depleting agents and lipid peroxidation. Chem. Phys. Lipids 1987, 45:143-169.
9. Corrao G., Torchio P., Zambon A., D'Amicis A., Lepore A., di Orio F. Alcohol consumption and micronutrient intake as risk factors for liver cirrhosis: a case-control study. Ann. Epidemiol. 1998, 8:154-159.
10. Fischer M., You M., Matsumoto M., Crabb D.W. Peroxisome proliferator-activated receptorα (PPARα) agonist treatment reverses PPARα dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J. Biol. Chem. 2003, 278:27997-28004.
11. Funaguchi N., Ohno Y., La B.L., Asai T., Yuhgetsu H., Sawada M., Takemura G., Minatoguchi S., Fujiwara T., Fujiwara H. Narirutin inhibits airway inflammation in an allergic mouse model. Clin. Exp. Pharmacol. Physiol. 2007, 34:766-770.
12. Gilmore T.D. Introduction to NF-κB: players, pathways, perspectives. Oncogene 2006, 25:6680-6684.
13. Ha S.K., Park H.Y., Eom H., Kim Y., Choi I. Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation. Food Chem. Toxicol. 2012, 50:3498-3504.
14. Kimura T., But P.P.H., Guo J.-X., Sung C.K. International Collation of Traditional and Folk Medicine: Northeast Asia 1996, World Scientific Publishing Co., River Edge.
15. Kono H., Rusyn I., Yin M., Gäbele E., Yamashina S., Dikalova A., Kadiiska M., Connor H., Mason R., Segal B., Bradford B., Holland S., Thurman R. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J. Clin. Invest. 2000, 106:867-872.
16. Kubo M., Fujita T., Nishimura S., Tokunaga M., Matsuda H., Gato T., Tomohiro N., Sasaki K., Utsunomiya N. Seasonal variation in anti-allergic activity of citrus fruits and flavanone glycoside content. Nat. Med. 2004, 58:11.
17. Lieber C.S. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 1997, 257:59-84.
18. Lieber C.S. Metabolism of alcohol. Clin. Liver Dis. 2005, 9:1-35.
19. Lind L. Circulating markers of inflammation and atherosclerosis. Atherosclerosis 2003, 169:203-214.
20. Nordmann R., Ribiere C., Rouach H. Ethanol-induced lipid peroxidation and oxidative stress in extrahepatic tissues. Alcohol Alcohol. 1990, 25:231-237.
21. Omoya T., Shimizu I., Zhou Y., Okamura Y., Inoue H., Lu G., Itonaga M., Honda H., Nomura M., Ito S. Effects of idoxifene and estradiol on NF-κB activation in cultured rat hepatocytes undergoing oxidative stress. Liver 2001, 21:183-191.
22. Park H.-Y., Park Y., Lee Y., Noh S.K., Sung E.-G., Choi I. Effect of oral administration of water-soluble extract from citrus peel (Citrus unshiu) on suppressing alcohol-induced fatty liver in rats. Food Chem. 2012, 130:598-604.
23. Quertemont E. Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. Mol. Psychiatry 2004, 9:570-581.
24. Schreck R., Rieber P., Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 1991, 10:2247-2258.
25. Song Z., Joshi-Barve S., Barve S., McClain C.J. Advances in alcoholic liver disease. Curr. Gastroenterol. Rep. 2004, 6:71-76.
26. Teschke R., Hasumura Y., Joly J.G., Ishii H., Lieber C.S. Microsomal ethanol-oxidizing system (MEOS): purification and properties of a rat liver system free of catalase and alcohol dehydrogenase. Biochem. Biophys. Res. Commun. 1972, 49:1187-1193.
27. Testino G. Alcoholic diseases in hepato-gastroenterology: a point of view. Hepatogastroenterology 2008, 55:371-377.
28. Tripoli E., Guardia M.L., Giammanco S., Majo D.D., Giammanco M. Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. Food Chem. 2007, 104:466-479.
29. Tuma D.J., Thiele G.M., Xu D., Klassen L.W., Sorrell M.F. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration. Hepatology 1996, 23:872-880.
30. Wheeler M.D. Endotoxin and kupffer cell activation in alcoholic liver disease. Alcohol. Res. Health 2003, 27:300-306.
31. Wu D., Cederbaum A.I. Alcohol, oxidative stress, and free radical damage. Alcohol. Res. Health 2003, 27:277-284.
32. Zakhari S. Overview: how is alcohol metabolized by the body?. Alcohol. Res. Health 2006, 29:245-254.