HIF proteins connect the RB-E2F factors to angiogenesis

Transcription

Volumn 4, Issue 2, 2013, Pages

  Bakker, Walbert J ^a   Weijts, Bart G M W ^a   Westendorp, Bart ^a   de Bruin, Alain ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Angiogenesis; Cancer; E2F; HIF; Hypoxia; RB; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F2; TRANSCRIPTION FACTOR E2F3; TRANSCRIPTION FACTOR E2F4; TRANSCRIPTION FACTOR E2F5; TRANSCRIPTION FACTOR E2F6; TRANSCRIPTION FACTOR E2F7; TRANSCRIPTION FACTOR E2F8; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1; REPRESSOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; DOWN REGULATION; E2F7 GENE; E2F8 GENE; GENE; GENE CLUSTER; GENE EXPRESSION REGULATION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PHENOTYPIC VARIATION; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TRANSCRIPTION INITIATION; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; UPREGULATION; ANIMAL; BINDING SITE; DEFICIENCY; GENETICS; HUMAN; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY;

ANIMALS; BINDING SITES; E2F TRANSCRIPTION FACTORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84874704924     PISSN: 21541264     EISSN: 21541272     Source Type: Journal    
DOI: 10.4161/trans.23680     Document Type: Article

References (30)

1. Weijts BG, Bakker WJ, Cornelissen PW, Liang KH, Schaftenaar FH, Westendorp B, et al. E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO J 2012; 31:3871-84. PMID:22903062. http://dx.doi.org/10.1038/emboj.2012.231
2. Chen HZ, Tsai SY, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer 2009; 9:785-97. PMID:19851314. http://dx.doi.org/10.1038/nrc2696
3. van den Heuvel S, Dyson NJ. Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol 2008; 9:713-24. PMID:18719710. http://dx.doi.org/10.1038/nrm2469
4. de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem 2003; 278:42041-9. PMID:12893818. http://dx.doi.org/10.1074/jbc.M308105200
5. Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, et al. Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem 2005; 280:18211-20. PMID:15722552. http://dx.doi.org/10.1074/jbc.M501410200
6. Di Stefano L, Jensen MR, Helin K. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J 2003; 22:6289-98. PMID:14633988. http://dx.doi.org/10.1093/emboj/ cdg613
7. Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, Bremner R. Division and apoptosis of E2f-deficient retinal progenitors. Nature 2009; 462:925-9. PMID:20016601. http://dx.doi.org/10.1038/nature08544
8. Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, et al. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 2009; 462:930-4. PMID:20016602. http://dx.doi.org/10.1038/nature08677
9. Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, et al. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell 2008; 14:62-75. PMID:18194653. http://dx.doi.org/10.1016/j.devcel.2007.10.017
10. Dunwoodie SL. The role of hypoxia in development of the Mammalian embryo. Dev Cell 2009; 17:755-73. PMID:20059947.http://dx.doi.org/10.1016/j.devcel.2009.11.008
11. Ouseph MM, Li J, Chen HZ, Pécot T, Wenzel P, Thompson JC, et al. Atypical E2F repressors and activators coordinate placental development. Dev Cell 2012; 22:849-62. PMID:22516201.http://dx.doi.org/10.1016/j.devcel.2012.01.013
12. Westendorp B, Mokry M, Groot Koerkamp MJ, Holstege FC, Cuppen E, de Bruin A. E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Res 2012; 40:3511-23. PMID:22180533. http://dx.doi.org/10.1093/nar/gkr1203.
13. Budde A, Schneiderhan-Marra N, Petersen G, Brüne B. Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1). Oncogene 2005; 24:1802-8. PMID:15674338. http://dx.doi.org/10.1038/sj.onc.1208369.
14. Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol 2007; 27:6229-42. PMID:17576813. http://dx.doi.org/10.1128/MCB.02246-06.
15. Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, et al. Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 2003; 421:942-7. PMID:12607001. http://dx.doi.org/10.1038/nature01417.
16. Hu T, Ghazaryan S, Sy C, Wiedmeyer C, Chang V, Wu L. Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia. Blood 2012; 119:4532-42. PMID:22422820. http://dx.doi.org/10.1182/blood-2011-10-388231.
17. Qin G, Kishore R, Dolan CM, Silver M, Wecker A, Luedemann CN, et al. Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A 2006; 103:11015-20. PMID:16835303. http://dx.doi.org/10.1073/pnas.0509533103.
18. Merdzhanova G, Gout S, Keramidas M, Edmond V, Coll JL, Brambilla C, et al. The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo. Oncogene 2010; 29:5392-403. PMID:20639906. http://dx.doi.org/10.1038/onc.2010.281.
19. Pillai S, Kovacs M, Chellappan S. Regulation of vascular endothelial growth factor receptors by Rb and E2F1: role of acetylation. Cancer Res 2010; 70:4931-40. PMID:20516113. http://dx.doi.org/10.1158/0008-5472.CAN-10-0501.
20. Gerber HP, Condorelli F, Park J, Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 1997; 272:23659-67. PMID:9295307. http://dx.doi.org/10.1074/jbc.272.38.23659.
21. Kappel A, Rönicke V, Damert A, Flamme I, Risau W, Breier G. Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/ enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice. Blood 1999; 93:4284-92. PMID:10361126.
22. Fontemaggi G, Dell'Orso S, Trisciuoglio D, Shay T, Melucci E, Fazi F, et al. The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. Nat Struct Mol Biol 2009; 16:1086-93. PMID:19783986. http://dx.doi.org/10.1038/nsmb.1669.
23. Martínez-Cruz AB, Santos M, Lara MF, Segrelles C, Ruiz S, Moral M, et al. Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer Res 2008; 68:683-92. PMID:18245467. http://dx.doi.org/10.1158/0008-5472.CAN-07-3049.
24. Toussaint-Smith E, Donner DB, Roman A. Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors. Oncogene 2004; 23:2988-95. PMID:14968115. http://dx.doi.org/10.1038/sj.onc.1207442.
25. Lasorella A, Rothschild G, Yokota Y, Russell RG, Iavarone A. Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Mol Cell Biol 2005; 25:3563-74. PMID:15831462. http://dx.doi.org/10.1128/MCB.25.9.3563-3574.2005.
26. Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, et al. A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice. Cancer Res 2008; 68:3810-8. PMID:18483265. http://dx.doi.org/10.1158/0008-5472.CAN-07-6672.
27. Dasgupta P, Sun J, Wang S, Fusaro G, Betts V, Padmanabhan J, et al. Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol 2004; 24:9527-41. PMID:15485920. http://dx.doi.org/10.1128/MCB.24.21.9527-9541.2004.
28. Liao D, Johnson RS. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev 2007; 26:281-90. PMID:17603752. http://dx.doi.org/10.1007/s10555-007-9066-y.
29. Keith B, Johnson RS, Simon MC. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2012; 12:9-22. PMID:22169972.
30. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721-32. PMID:13130303.http://dx.doi.org/10.1038/nrc1187