Regulation of vascular endothelial growth factor receptors by Rb and E2F1: Role of acetylation

Cancer Research

Volumn 70, Issue 12, 2010, Pages 4931-4940

  Pillai, Smitha ^a   Kovacs, Michelle ^a   Chellappan, Srikumar ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; HISTONE; HISTONE ACETYLTRANSFERASE PCAF; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ACETYLATION; ANGIOGENESIS; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

ACETYLATION; ANGIOPOIETIN-2; AORTA; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; E2F1 TRANSCRIPTION FACTOR; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HISTONES; HUMANS; LUCIFERASES; LUNG; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77953756024     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0501     Document Type: Article

References (50)

1. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR. The E2F transcription factor is a cellular target for the RB protein. Cell 1991;65:1053-61. (Pubitemid 121001693)
2. Nevins JR.Toward an understanding of the functionalcomplexity of the E2F and retinoblastoma families. Cell Growth Differ 1998;9:585-93.
3. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 1998;12:2245-62.
4. Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002;3:11-20.
5. Slansky JE, Farnham PJ. Introduction to the E2F family: protein structure and gene regulation. Curr Top Microbiol Immunol 1996;208:1-30.
6. DeGregori J, Johnson DG. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 2006;6:739-48. (Pubitemid 44725567)
7. Cobrinik D. Pocket proteins and cell cycle control. Oncogene 2005;24:2796-809. (Pubitemid 40638091)
8. Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc Natl Acad Sci U S A 1998;95:2850-5.
9. Christensen J, Cloos P, Toftegaard U, et al. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res 2005;33:5458-70. (Pubitemid 41548812)
10. Logan N, Graham A, Zhao X, et al. E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. Oncogene 2005;24:5000-4. (Pubitemid 41129104)
11. Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet 1998;18:360-4. (Pubitemid 28158165)
12. Field SJ, Tsai FY, Kuo F, et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 1996;85:549-61. (Pubitemid 26157193)
13. Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene 2005;24:2204-17. (Pubitemid 40516587)
14. Kinkade R, Dasgupta P, Carie A, et al. A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice. Cancer Res 2008;68:3810-8.
15. Pillai S, Chellappan SP. ChIP on chip assays: genome-wide analysis of transcription factor binding and histone modifications. Methods Mol Biol 2009;523:341-66.
16. Reid G, Hubner MR, Metivier R, et al. Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling. Mol Cell 2003;11:695-707. (Pubitemid 36385123)
17. Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J Biol Chem 2003;278:47853-61. (Pubitemid 37523233)
18. Dasgupta P, Sun J, Wang S, et al. Disruption of the Rb-Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol 2004;24:9527-41. (Pubitemid 39391689)
19. Clayton AL, Hazzalin CA, Mahadevan LC. Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell 2006;23:289-96.
20. Trouche D, Cook A, Kouzarides T. The CBP co-activator stimulates E2F1/DP1 activity. Nucleic Acids Res 1996;24:4139-45. (Pubitemid 26377326)
21. Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J 2000;19:662-71.
22. Beecken WD, Engl T, Ringel EM, et al. An endogenous inhibitor of angiogenesis derived from a transitional cell carcinoma: clipped β2-glycoprotein-I. Ann Surg Oncol 2006;13:1241-51. (Pubitemid 44440426)
23. Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med 1998;49:407-24.
24. Bellamy WT. Vascular endothelial growth factor as a target opportunity in hematological malignancies. Curr Opin Oncol 2002;14:649-56.
25. Abdelrahim M, Baker CH, Abbruzzese JL, et al. Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Res 2007;67:3286-94.
26. Fong GH, Zhang L, Bryce DM, Peng J. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development 1999;126:3015-25. (Pubitemid 29355693)
27. Park JE, Chen HH, Winer J, Houck KA, Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 1994;269:25646-54. (Pubitemid 24982909)
28. Rahimi N, Dayanir V, Lashkari K. Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem 2000;275:16986-92. (Pubitemid 30398939)
29. Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate. Proc Natl Acad Sci U S A 1998;95:8795-800.
30. Wey JS, Fan F, Gray MJ, et al. Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines. Cancer 2005;104:427-38. (Pubitemid 40993273)
31. Fan F, Wey JS, McCarty MF, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005;24:2647-53. (Pubitemid 40593092)
32. Ferrara N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol 2002;29:10-4.
33. Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995;376:62-6.
34. Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997;277:55-60.
35. Gale NW, Thurston G, Hackett SF, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell 2002;3:411-23.
36. Lobov IB, Brooks PC, Lang RA. Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A 2002;99:11205-10.
37. Higgins KJ, Abdelrahim M, Liu S, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Biochem Biophys Res Commun 2006;345:292-301. (Pubitemid 44269283)
38. Lin SY, Black AR, Kostic D, Pajovic S, Hoover CN, Azizkhan JC. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol Cell Biol 1996;16:1668-75. (Pubitemid 26095639)
39. Luo RX, Postigo AA, Dean DC. Rb interacts with histone deacetylase to repress transcription. Cell 1998;92:463-73.
40. Gabellini C, Del Bufalo D, Zupi G. Involvement of RB gene family in tumor angiogenesis. Oncogene 2006;25:5326-32. (Pubitemid 44299094)
41. Tashiro E, Minato Y, Maruki H, Asagiri M, Imoto M. Regulation of FGF receptor-2 expression by transcription factor E2F-1. Oncogene 2003;22:5630-5. (Pubitemid 37102699)
42. Tashiro E, Maruki H, Minato Y, Doki Y, Weinstein IB, Imoto M. Overexpression of cyclinD1 contributes tomalignancy by up-regulation of fibroblast growth factor receptor 1 via the pRB/E2F pathway. Cancer Res 2003;63:424-31. (Pubitemid 36152503)
43. Kanai M, Tashiro E, Maruki H, Minato Y, Imoto M. Transcriptional regulation of human fibroblast growth factor receptor 1 by E2F-1. Gene 2009;438:49-56.
44. Minato Y, Tashiro E, Kanai M, Nihei Y, Kodama Y, Imoto M. Transcriptional regulation of a new variant of human platelet-derived growth factor receptor α transcript by E2F-1. Gene 2007;403:89-97. (Pubitemid 47488717)
45. Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 2001;15:1833-44.
46. Gu W, Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997;90:595-606. (Pubitemid 27357952)
47. Boyes J, Byfield P, Nakatani Y, Ogryzko V. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 1998;396:594-8. (Pubitemid 28563723)
48. Zhang W, Bieker JJ. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci U S A 1998;95:9855-60.
49. Choudhary C, Kumar C, Gnad F, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009;325:834-40.
50. Pediconi N, Ianari A, Costanzo A, et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol 2003;5:552-8. (Pubitemid 36781090)