Ameliorating effects of casein glycomacropeptide on obesity induced by high-fat diet in male Sprague-Dawley rats

Food and Chemical Toxicology

Volumn 56, Issue , 2013, Pages 1-7

  Xu, Shi Ping ^a   Mao, Xue Ying ^a   Cheng, Xue ^a   Chen, Bin ^b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b China Astronaut Research and Training Center   (China)

Author keywords

Anti obesity; Casein glycomacropeptide (GMP); Lipid accumulation; Obese rat

Indexed keywords

CASEIN GLYCOPROTEIN; CHOLESTEROL; FAT DROPLET; FATTY ACID SYNTHASE; GLUTATHIONE PEROXIDASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE WEIGHT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; EPIDIDYMIS FAT; FATTY LIVER; HISTOPATHOLOGY; LIPID ANALYSIS; LIPID DIET; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID STORAGE; LIVER CELL; LIVER WEIGHT; LOW DRUG DOSE; MALE; NONHUMAN; OBESITY; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; CASEINS; CHOLESTEROL; DIET, HIGH-FAT; FATTY ACID SYNTHASES; FATTY LIVER; GLYCEROLPHOSPHATE DEHYDROGENASE; INTERLEUKIN-6; LEPTIN; LIVER; MALE; OBESITY; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84874673304     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.01.027     Document Type: Article

References (34)

1. Azuma N., Yamauchi K., Mitsuoka T. Bifidus growth-promoting activity of a glycomacropeptide derived from human κ-casein. J. Agric. Biol. Chem. 1984, 48:2159-2162.
2. Bruck W.M., Kelleher S.L., Gibson G.R., Graverholt G., Lonnerdal B.L. The effects of α-lactalbumin and glycomacropeptide on the association of Caco-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri. FEMS Microbiol. Lett. 2006, 259:158-162.
3. Causey K.R., Zemel M.B. Dairy augmentation of the anti-obesity effect of Ca in a aP2-agouti transgenic mice. FASEB J. 2003, 17:A746.
4. Cho A.S., Jeon S.M., Kim M.J., Yeo J.Y., Seo K.I., Choi M.S., Lee M.K. Caffeic acid and chlorogenic acid improve body weight, lipid metabolism and obesity-related hormones levels in high-fat fed mice. Food Chem. Toxicol. 2010, 48:937-943.
5. Choi M.S., Lee M.K., Jung U.J., Kim H.J., Do G.M., Park Y.B., Jeon S.M. Metabolic response of soy pinitol on lipid-lowering, antioxidant and hepatoprotective action in hamsters fed-high fat and high cholesterol diet. Mol. Nutr. Food Res. 2009, 53:751-759.
6. Daddaoua A., Puerta V., Zarzuelo A., Suarez M.D., de Medina F.S., Marti{dotless}nez-Augustin O. Bovine glycomacropeptide is anti-inflammatory in rats with hapten-induced colitis. J. Nutr. 2005, 135:1164-1170.
7. Del Rio D., Stewart A.J., Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr. Metab. Cardiovasc. Dis. 2005, 15:316-328.
8. Folch J., Lees M., Sloane-Stanley G.H. A simple method for isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957, 226:497-509.
9. Fouillet H., Mariotti F., Gaudichon C., Bos C., Daniel T. Peripheral and splanchnic metabolism of dietary nitrogen are differently affected by the protein source in humans as assessed by compartmental modeling. J. Nutr. 2002, 132:125-133.
10. Ha E., Zemel M.B. Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people. J. Nutr. Biochem. 2003, 14:251-258.
11. Hall W., Millward D.J., Long S.J., Morgan L.M. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br. J. Nutr. 2003, 89:2392-2398.
12. Hulcher F.H., Oleson W.H. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J. Lipid Res. 1973, 14:625-631.
13. Hursel R., van der Zee L., Westerterp-Plantenga M.S. Effects of a breakfast yoghurt, with additional total whey protein or caseinomacropeptide-depleted alpha-lactalbumin-enriched whey protein, on diet-induced thermogenesis and appetite suppression. Br. J. Nutr. 2010, 103:775-780.
14. Keogh J.B., Clifton P. The effect of meal replacement high in glycomacropeptide on weight loss and marker of cardiovascular disease risk. Am. J. Clin. Nutr. 2008, 87:1602-1605.
15. Kim Y.J., Oh Y.K., Yoo S.S., Park K.Y., Kang W., Park S. Antiobesity effect of recombinant human caseinomacropeptide in Sprague-Dawley rat. Biotechnol. Bioprocess Eng. 2005, 10:242-247.
16. Kopelman P.G. Obesity as a medical problem. Nature 2000, 404:635-643.
17. Lopez-Posadas R., Requena P., Gonzalez R., Suarez M.D., Zarzuelo A., Sanchez de Medina F., Martinez-Augustin O. Bovine glycomacropeptide has intestinal anti-inflammatory effects in rats with dextran sulfate-induced colitis. J. Nutr. 2010, 140:2014-2019.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
19. Mann J.I. Diet and risk of coronary heart disease and type 2 diabetes. Lancet 2002, 360:783-789.
20. Mark R.E. Manufacture and use of dairy protein fractions. J. Nutr. 2004, 134:996S-1002S.
21. Martinez-Villaluenga C., Dia V.P., Berhow M., Bringe N.A., Gonzalez-de Mejia E. Protein hydrolysates from β-conglycinin enriched soybean genotypes inhibit lipid accumulation and inflammation in vitro. Mol. Nutr. Food Res. 2009, 53:1007-1018.
22. Miguel M., Manso M.A., Lopez-Fandinob R., Alonso M.J., Salaices M. Vascular effects and antihypertensive properties of κ-casein macropeptide. Int. Dairy J. 2007, 17:1473-1477.
23. National Research Council, 1985. Guide for the Care and Use of Laboratory Animals. NIH Publication No. 85. Bethesda, MD: National Institutes of Health, 23.
24. Ney D.M., Hull A.K., van Calcar S.C., Liu X.W., Etzel M.R. Dietary glycomacropeptide supports growth and reduces the concentrations of phenylalanine in plasma and brain in a murine model of phenylketonuria. J. Nutr. 2008, 138:316-322.
25. Olusi S.O. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. Int. J. Obes. Relat. Metab. Disord. 2002, 26:1159-1164.
26. Ozata M., Mergen M., Oktenli C., Aydin A., Sanisoglu S.Y., Bolu E., Yilmaz M.I., Sayal A., Isimer A., Ozdemir I.C. Increased oxidative stress and hypozincemia in male obesity. Clin. Biochem. 2002, 35:627-631.
27. Pal S., Ellis V., Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br. J. Nutr. 2010, 9:1-8.
28. Peng C.H., Liu L.K., Chuang C.M., Chyau C.C., Huang C.N., Wang C.J. Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis. J. Agric. Food Chem. 2011, 59:2663-2671.
29. Pilvi T.K., Korpela R., Huttunen M., Vapaatalo H., Mervaala E.M. High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice. Br. J. Nutr. 2008, 99:739-748.
30. Royle P.J., McIntosh G.H., Clifton P.M. Whey protein isolate and glycomacropeptide decrease weight gain and alter body composition in male Wistar rats. Br. J. Nutr. 2008, 100:88-93.
31. Solverson P., Murali S.G., Brinkman A.S., Nelson D.W., Clayton M.K., Yen C.L.E., Ney D.M. Glycomacropeptide, a low-phenylalanine protein isolated from cheese whey, supports growth and attenuates metabolic stress in the murine model of phenylketonuria. Am. J. Physiol. Endocrinol. Metab. 2012, 302:E885-E895.
32. Wise L.S., Green H. Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J. Biol. Chem. 1979, 254:273-275.
33. Xu S.P., Mao X.Y., Ren F.Z., Che H.L. Attenuating effect of casein glycomacropeptide on proliferation, differentiation, and lipid accumulation of in vitro Sprague-Dawley rat preadipocytes. J. Dairy Sci. 2011, 94:676-683.
34. Zou Y.H., Li J., Lu C., Wang J.Q., Ge J.F., Huang Y., Zhang L., Yang Y.Y. High-fat emulsion induced rat model of nonalcoholic steatohepatitis. Life Sci. 2006, 79:1100-1107.