Aldehyde dehydrogenase and HSP90 co-localize in human glioblastoma biopsy cells

Biochimie

Volumn 95, Issue 4, 2013, Pages 782-786

  Rappa, F ^a   Cappello, F ^a   Halatsch, M E ^b   Scheuerle, A ^b   Kast, R E ^c  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF ULM   (Germany)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Aldehyde dehydrogenase; Disulfiram; Glioblastoma; HSP90; Ritonavir; Stem cell; Temozolomide

Indexed keywords

ALDEHYDE DEHYDROGENASE; HEAT SHOCK PROTEIN 90;

ARTICLE; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR BIOPSY; TUMOR CELL;

ALDEHYDE DEHYDROGENASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PROTEIN TRANSPORT;

EID: 84874664791     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.11.007     Document Type: Article

References (49)

1. O. Keunen, M. Johansson, A. Oudin, M. Sanzey, S.A. Rahim, F. Fack, F. Thorsen, T. Taxt, M. Bartos, R. Jirik, H. Miletic, J. Wang, D. Stieber, L. Stuhr, I. Moen, C.B. Rygh, R. Bjerkvig, and S.P. Niclou Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma Proc. Natl. Acad. Sci. U S A 108 2011 3749 3754
2. M.O. Stefanini, F.T. Wu, F. Mac Gabhann, and A.S. Popel Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model Cancer Res. 70 2010 9886 9894
3. A.K. Lucio-Eterovic, Y. Piao, and J.F. de Groot Mediators of glioblastoma resistance and invasion during anti-vascular endothelial growth factor therapy Clin. Cancer Res. 15 2009 4589 4599
4. C.M. Park, M.J. Park, H.J. Kwak, H.C. Lee, M.S. Kim, S.H. Lee, I.C. Park, C.H. Rhee, and S.I. Hong Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways Cancer Res. 66 2006 85119
5. M. Martinou, E. Giannopoulou, G. Malatara, A.A. Argyriou, H.P. Kalofonos, and D. Kardamakis Ionizing radiation affects epidermal growth factor receptor signalling and metalloproteinase secretion in glioma cells Cancer Genom. Proteom. 8 2011 33 38
6. G.P. Dunn, M.L. Rinne, J. Wykosky, G. Genovese, S.N. Quayle, I.F. Dunn, P.K. Agarwalla, M.G. Chheda, B. Campos, A. Wang, C. Brennan, K.L. Ligon, F. Furnari, W.K. Cavenee, R.A. Depinho, L. Chin, and W.C. Hahn Emerging insights into the molecular and cellular basis of glioblastoma Genes Dev. 26 2012 756 784
7. ®) and postoperative radiotherapy with concomitant temozolomide followed by adjuvant temozolomide: a clinical review Br. J. Neurosurg. 25 2011 459 469
8. L. Persano, E. Rampazzo, A. Della Puppa, F. Pistollato, and G. Basso The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications Scientific World J. 11 2011 1829 1841
9. E.K. Nduom, C.G. Hadjipanayis, and E.G. Van Meir Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment Cancer J. 18 2012 100 106
10. R.E. Kast, and M.-E. Halatsch Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in Glioblastoma Arch. Med. Res. 43 2012 243 247
11. R.E. Kast, F. Lefranc, G. Karpel-Massler, and M.-E. Halatsch Why dapsone stops seizures and may stop neutrophils' delivery of VEGF to glioblastoma Br. J. Neurosurg. 2012 May 2 [Epub ahead of print] PubMed PMID: 22551309
12. R.E. Kast Glioblastoma: synergy of growth promotion between CCL5 and NK-1R can be thwarted by blocking CCL5 with miraviroc, an FDA approved anti-HIV drug and blocking NK-1R with aprepitant, an FDA approved anti-nausea drug J. Clin. Pharm. Ther. 35 2010 657 663
13. R.E. Kast, G. Karpel-Massler, and M.-E. Halatsch Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin? Br. J. Pharmacol. 164 2011 1393 1396
14. J. Triscott, C. Lee, K. Hu, A. Fotovati, R. Berns, M. Pambid, M. Luk, R.E. Kast, E. Kong, E. Toyota, S. Yip, B. Toyota, and S.E. Dunn Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide Oncotarget 2012 Oct 8 [Epub ahead of print] PubMed PMID: 23047041
15. P. Liu, S. Brown, T. Goktug, P. Channathodiyil, V. Kannappan, J.P. Hugnot, P.O. Guichet, X. Bian, A.L. Armesilla, J.L. Darling, and W. Wang Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells Br. J. Cancer 107 2012 1488 1497
16. M. Rasper, A. Schäfer, G. Piontek, J. Teufel, G. Brockhoff, F. Ringel, S. Heindl, C. Zimmer, and J. Schlegel Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity Neuro. Oncol. 12 2010 1024 1033
17. J. Douville, R. Beaulieu, and D. Balicki ALDH1 as a functional marker of cancer stem and progenitor cells Stem Cells Dev. 18 2009 17 25
18. R.E. Kast, and C. Belda-Iniesta Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis Curr. Stem Cell Res. Ther. 4 2009 314 317
19. L. Neckers Heat shock protein 90: the cancer chaperone J. Biosci. 32 2007 517 530
20. A. Shervington, N. Cruickshanks, H. Wright, R. Atkinson-Dell, R. Lea, G. Roberts, and J. Shervington Glioma: what is the role of c-Myc, hsp90 and telomerase? Mol. Cell. Biochem. 283 2006 1 9
21. A. Citri, B.S. Kochupurakkal, and Y. Yarden The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention Cell Cycle 3 2004 51 60
22. Y.S. Zhao, T.Z. Zhu, Y.W. Chen, Y.Q. Yao, C.M. Wu, Z.Q. Wei, W. Wang, and Y.H. Xu B-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells J. Neurooncol. 107 2012 307 314
23. T. Barliya, M. Mandel, T. Livnat, D. Weinberger, and G. Lavie Degradation of HIF1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy PLoS One 6 2011 e22849
24. U. Gopal, J.E. Bohonowych, C. Lema-Tome, A. Liu, E. Garrett-Mayer, B. Wang, and J.S. Isaacs A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion PLoS One 6 2011 e17649
25. I. Fleming Molecular mechanisms underlying the activation of eNOS Pflugers Arch. 459 2010 793 806
26. N. Kobayashi, S. Toyooka, J. Soh, H. Yamamoto, H. Dote, K. Kawasaki, H. Otani, T. Kubo, M. Jida, T. Ueno, M. Ando, A. Ogino, K. Kiura, and S. Miyoshi The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor Lung Cancer 75 2012 161 166
27. Y. Jiao, W. Ou, F. Meng, H. Zhou, and A. Wang Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation Mol. Cancer 10 2011 125
28. K.H. Wrighton, X. Lin, and X.H. Feng Critical regulation of TGFbeta signaling by Hsp90 Proc. Natl. Acad. Sci. U S A 105 2008 9244 9249
29. V.C. da Silva, and C.H. Ramos The network interaction of the human cytosolic 90 kDa heat shock protein Hsp90: a target for cancer therapeutics J. Proteom. 75 2012 2790 2802
30. C.H. Lee, H.M. Hong, Y.Y. Chang, and W.W. Chang Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells Biochimie 94 2012 1382 1389
31. V. Quemener, J.P. Moulinoux, C. Martin, F. Darcel, Y. Guegan, J. Faivre, and G.A. Quash Aldehyde dehydrogenase activity in xenografted human brain tumor in nude mice. Preliminary results in human glioma biopsies J. Neurooncol. 9 1990 115 123
32. A. O'Brien, J.E. Barber, S. Reid, N. Niknejad, and J. Dimitroulakos Enhancement of cisplatin cytotoxicity by disulfiram involves activating transcription factor 3 Anticancer Res. 32 2012 2679 2688
33. N.C. Yip, I.S. Fombon, P. Liu, S. Brown, V. Kannappan, A.L. Armesilla, B. Xu, J. Cassidy, J.L. Darling, and W. Wang Disulfiram modulated ROS-MAPK and NF.B pathways and targeted breast cancer cells with cancer stem cell-like properties Br. J. Cancer 104 2011 1564 1574
34. X. Guo, B. Xu, S. Pandey, E. Goessl, J. Brown, A.L. Armesilla, J.L. Darling, and W. Wang Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines Cancer Lett. 290 2010 104 113
35. E. Dalla Pozza, M. Donadelli, C. Costanzo, T. Zaniboni, I. Dando, M. Franchini, S. Arpicco, A. Scarpa, and M. Palmieri Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives Free Radic. Biol. Med. 50 2011 926 933
36. D.R. Budman, and A. Calabro In vitro search for synergy and antagonism: evaluation of docetaxel combinations in breast cancer cell lines Breast Cancer Res. Treat. 74 2002 41 46
37. J.S. Moreb, D. Ucar, S. Han, J.K. Amory, A.S. Goldstein, B. Ostmark, and L.J. Chang The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance Chem. Biol. Interact. 195 2012 52 60
38. W. Wang, H.L. McLeod, and J. Cassidy Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines Int. J. Cancer 104 2003 504 511
39. B. Xu, P. Shi, I.S. Fombon, Y. Zhang, F. Huang, W. Wang, and S. Zhou Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells Blood Cells Mol. Dis. 47 2011 264 269
40. S. Verma, D.J. Stewart, J.A. Maroun, and R.C. Nair A randomized phase II study of cisplatin alone versus cisplatin plus disulfiram Am. J. Clin. Oncol. 13 1990 119 124
41. S.S. Brar, C. Grigg, K.S. Wilson, W.D. Holder Jr., D. Dreau, C. Austin, M. Foster, A.J. Ghio, A.R.Whorton, G.W. Stowell, L.B. Whittall, R.R. Whittle, D.P. White, and T.P. Kennedy Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal dependent manner in vitro, in mice and in a patient with metastatic disease Mol. Cancer Ther. 3 2004 1049 1060
42. H.M. Strik, M. Weller, B. Frank, M. Hermisson, M.H. Deininger, J. Dichgans, and R. Meyermann Heat shock protein expression in human gliomas Anticancer Res. 20 2000 4457 4462
43. A. Sato, T. Asano, K. Ito, and T. Asano 17-Allylamino-17- demethoxygeldanamycin and ritonavir inhibit renal cancer growth by inhibiting the expression of heat shock factor-1 Int. J. Oncol. 41 2012 46 52
44. P. Joshi, and C.A. Stoddart Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1 J. Biol. Chem. 286 2011 24581 24592
45. A. Srirangam, R. Mitra, M. Wang, J.C. Gorski, S. Badve, L. Baldridge, J. Hamilton, H. Kishimoto, J. Hawes, L. Li, C.M. Orschell, E.F. Srour, J.S. Blum, D. Donner, G.W. Sledge, H. Nakshatri, and D.A. Potter Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer Clin. Cancer Res. 12 2006 1883 1896
46. A. Haupt, G. Joberty, M. Bantscheff, H. Frohlich, H. Stehr, M.R. Schweiger, A. Fischer, M. Kerick, S.T. Boerno, A. Dahl, M. Lappe, H. Lehrach, C. Gonzalez, G. Drewes, and B.M. Lange Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signaling components in cancer cells revealed by kinase-targeted chemoproteomics BMC Cancer 12 2012 38
47. Y. Khaliq, K. Gallicano, S. Venance, S. Kravcik, and D.W. Cameron Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus Clin. Pharmacol. Ther. 68 2000 637 646
48. S. Ohba, Y. Hirose, K. Yoshida, T. Yazaki, and T. Kawase Inhibition of 90-kD heat shock protein potentiates the cytotoxicity of chemotherapeutic agents in human glioma cells J. Neurosurg. 112 2010 33 42
49. M.D. Siegelin, J. Plescia, C.M. Raskett, C.A. Gilbert, A.H. Ross, and D.C. Altieri Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma Mol. Cancer Ther. 9 2010 1638 1646