Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives

Free Radical Biology and Medicine

Volumn 50, Issue 8, 2011, Pages 926-933

  Dalla Pozza, Elisa ^a   Donadelli, Massimo ^a   Costanzo, Chiara ^a   Zaniboni, Tatyana ^a   Dando, Ilaria ^a   Franchini, Marta ^a   Arpicco, Silvia ^b   Scarpa, Aldo ^a   Palmieri, Marta ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Apoptosis; Dithiocarbamate; Free radicals; Gemcitabine; Oxidative stress; Pancreatic adenocarcinoma; Zinc

Indexed keywords

DISULFIRAM; GEMCITABINE; MANGANESE SUPEROXIDE DISMUTASE; OXYGEN; PROTEIN P53; PYRROLIDINE DITHIOCARBAMATE; ZINC ION; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER RESISTANCE; CARCINOMA CELL; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; TREATMENT RESPONSE;

ADENOCARCINOMA; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYCYTIDINE; DRUG SYNERGISM; HUMANS; PANCREATIC NEOPLASMS; THIOCARBAMATES;

MUS MUSCULUS;

EID: 79952449378     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.01.001     Document Type: Article

References (27)

1. D. Li, K. Xie, R. Wolff, and J.L. Abbruzzese Pancreatic cancer Lancet 363 2004 1049 1057 (Pubitemid 38410779)
2. J.P. Neoptolemos, D. Cunningham, H. Friess, C. Bassi, D.D. Stocken, D.M. Tait, J.A. Dunn, C. Dervenis, F. Lacaine, H. Hickey, M.G. Raraty, P. Ghaneh, and M.W. Büchler Adjuvant therapy in pancreatic cancer: historical and current perspectives Ann. Oncol. 14 2003 675 692 (Pubitemid 36621766)
3. H.A. Burris, M.J. Moore, J. Andersen, M.R. Green, M.L. Rothenberg, M.R. Modiano, M.C. Cripps, R.K. Portenoy, A.M. Storniolo, P. Tarassoff, R. Nelson, F.A. Dorr, C.D. Stephens, and D.D. Von Hoff Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J. Clin. Oncol. 15 1997 2403 2413 (Pubitemid 27251144)
4. M. Ducreux, V. Boige, and D. Malka Treatment of advanced pancreatic cancer Semin. Oncol. 34 2007 S25 S30
5. A. Laurent, C. Nicco, C. Chereau, C. Goulvestre, J. Alexandre, A. Alves, E. Levy, F. Goldwasser, Y. Panis, O. Soubrane, B. Weill, and F. Batteux Controlling tumor growth by modulating endogenous production of reactive oxygen species Cancer Res. 65 2005 948 956 (Pubitemid 40216456)
6. M. Donadelli, C. Costanzo, S. Beghelli, M.T. Scupoli, M. Dandrea, A. Bonora, P. Piacentini, A. Budillon, M. Caraglia, A. Scarpa, and M. Palmieri Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine Biochim. Biophys. Acta 1773 2007 1095 1106 (Pubitemid 46898677)
7. M. Donadelli, E. Dalla Pozza, C. Costanzo, M.T. Scupoli, P. Piacentini, A. Scarpa, and M. Palmieri Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate Biochim. Biophys. Acta 1763 2006 917 926 (Pubitemid 44332597)
8. M. Donadelli, E. Dalla Pozza, M.T. Scupoli, C. Costanzo, A. Scarpa, and M. Palmieri Intracellular zinc increase inhibits p53(-/-) pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis Biochim. Biophys. Acta 1793 2009 273 280
9. Z.E. Sauna, S. Shukla, and S.V. Ambudkar Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections Mol. Biosyst. 1 2005 127 134 (Pubitemid 43362238)
10. D.I. Eneanya, J.R. Bianchine, D.O. Duran, and B.D. Andresen The actions of metabolic fate of disulfiram Annu. Rev. Pharmacol. Toxicol. 21 1981 575 596
11. R.K. Fuller, and E. Gordis Does disulfiram have a role in alcoholism treatment today? Addiction 99 2004 21 24 (Pubitemid 38142216)
12. P.S. Moore, B. Sipos, S. Orlandini, C. Sorio, F.X. Real, N.R. Lemoine, T. Gress, C. Bassi, G. Kloppel, H. Kalthoff, H. Ungefroren, M. Lohr, and A. Scarpa Genetic profile of 22 pancreatic carcinoma cell lines: analysis of K-ras, p53, p16 and DPC4/Smad4 Virchows Arch. 439 2001 798 802 (Pubitemid 33141325)
13. F. Bruzzese, E. Di Gennaro, A. Avallone, S. Pepe, C. Arra, M. Caraglia, P. Tagliaferri, and A. Budillon Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head and neck cancer cells in vitro and in vivo Clin. Cancer Res. 12 2006 617 625 (Pubitemid 43166157)
14. T.C. Chou, and P. Talalay Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv. Enzyme Regul. 22 1984 27 55
15. P. Piacentini, M. Donadelli, C. Costanzo, P.S. Moore, M. Palmieri, and A. Scarpa Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation Virchows Arch. 448 2006 797 804 (Pubitemid 43824437)
16. H. Pelicano, D. Carney, and P. Huang ROS stress in cancer cells and therapeutic implications Drug Resist. Update 7 2004 97 110 (Pubitemid 38736063)
17. D.E. Modrak, E. Leon, D.M. Goldenberg, and D.V. Gold Ceramide regulates gemcitabine-induced senescence and apoptosis in human pancreatic cancer cell lines Mol. Cancer Res. 7 2009 890 896
18. C.A. Dumitru, I.E. Sandalcioglu, M. Wagner, M. Weller, and E. Gulbins Lysosomal ceramide mediates gemcitabine-induced death of glioma cells J. Mol. Med. 87 2009 1123 1132
19. C. Garcia-Ruiz, A. Colell, M. Mari, A. Morales, and J.C. Fernandez-Checa Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: role of mitochondrial glutathione J. Biol. Chem. 272 1997 11369 11377 (Pubitemid 27184141)
20. E.M. Hurt, S.B. Thomas, B. Peng, and W.L. Farrar Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines Br. J. Cancer 97 2007 1116 1123 (Pubitemid 47587014)
21. V.L. Kinnula, and J.D. Crapo Superoxide dismutases in malignant cells and human tumors Free Radic. Biol. Med. 36 2004 718 744 (Pubitemid 38264416)
22. W. Wang, H.L. McLeod, and J. Cassidy Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines Int. J. Cancer 104 2003 504 511 (Pubitemid 36323923)
23. M. Wickstrom, K. Danielsson, L. Rickardson, J. Gullbo, P. Nygren, A. Isaksson, R. Larsson, and H. Lovborg Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients Biochem. Pharmacol. 73 2007 25 33 (Pubitemid 44872876)
24. S.G. Shian, Y.R. Kao, F.Y. Wu, and C.W. Wu Inhibition of invasion and angiogenesis by zinc-chelating agent disulfiram Mol. Pharmacol. 64 2003 1076 1084 (Pubitemid 37310740)
25. S.S. Brar, C. Grigg, K.S. Wilson, W.D. Holder Jr., D. Dreau, C. Austin, M. Foster, A.J. Ghio, A.R. Whorton, G.W. Stowell, L.B. Whittall, R.R. Whittle, D.P. White, and T.P. Kennedy Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease Mol. Cancer Ther. 3 2004 1049 1060 (Pubitemid 39295002)
26. X. Guo, B. Xu, S. Pandey, E. Goessl, J. Brown, A.L. Armesilla, J.L. Darling, and W. Wang Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines Cancer Lett. 290 2010 104 113
27. K. Iljin, K. Ketola, P. Vainio, P. Halonen, P. Kohonen, V. Fey, R.C. Grafstrom, M. Perala, and O. Kallioniemi High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth Clin. Cancer Res. 15 2009 6070 6078